Development of a Method for Producing Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Using Fusion Protein Technology

• Published in: Current issues in molecular biology Vol. 47; no. 9; p. 681
• Main Authors: Volosnikova, Ekaterina A., Esina, Tatiana I., Volkova, Natalia V., Belenkaya, Svetlana V., Gogina, Yana S., Shimina, Galina G., Vyazovaya, Elena A., Gamaley, Svetlana G., Danilenko, Elena D., Shcherbakov, Dmitriy N.
• Format: Journal Article
• Language: English
• Published: 25.08.2025

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine with therapeutic applications in oncology and neurodegenerative diseases. However, its clinical use is limited by the high cost of eukaryotic production systems. Here, we developed a cost-effective Escherichia co...