MO661: Elimination of Middle and Large Uraemic Toxins in Short Daily Home Haemodialysis with Low Dialysate Volume: A Randomized Crossover Clinical Trial
Abstract BACKGROUND AND AIMS Portable haemodialysis (HD) systems with a low dialysate flow rate in a short frequent schedule have become an attractive option for patients on home HD (HHD). Although these systems have been demonstrated to be effective for removing low weight molecular uraemic toxins,...
Saved in:
Published in | Nephrology, dialysis, transplantation Vol. 37; no. Supplement_3 |
---|---|
Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
03.05.2022
|
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
BACKGROUND AND AIMS
Portable haemodialysis (HD) systems with a low dialysate flow rate in a short frequent schedule have become an attractive option for patients on home HD (HHD). Although these systems have been demonstrated to be effective for removing low weight molecular uraemic toxins, there are few data on their removal ability of higher molecular weight toxins. This study assessed the uraemic toxin removal ability of the portable Physidia S3 Monitor in a short, frequent, 5 days/week, low-dialysate flux HHD versus 3 days/week, in centre online haemodiafiltration (OL-HDF).
METHOD
In an open, randomized, cross-over, single-centre, controlled, prospective study, 40 adult chronic HD patients were treated by a 2.5-h low flux dialysate HD session or a 4-h post-dilution OL-HDF. All other dialysis parameters including dialyzer (polysulfone high-flux dialyzer NS 1.8, Toray®) were kept constant in both the study arms. The weekly reduction rate (RR) and the weekly eliminated mass into dialysate (EM) of urea, creatinine, phosphate, β2-microglobulin, kappa (κFLC) and lambda (λFLC) free light chains and albumin, were intra-individually compared for the two dialysis types with linear mixed models.
RESULTS
There were no significant differences in the RR for urea, phosphate, κFLC and albumin, whereas the weekly RRs for creatinine and β2-microglobulin were significantly higher with the Physidia S3 system than those obtained with OL-HDF (Table). Only the λFLC RR was significantly higher with OL-HDF. Similar results were observed when weekly EMs were compared (data not shown).
CONCLUSION
This study demonstrates that treating patients with low flow dialysate HHD in a short frequent schedule with Physidia S3 system, instead of 3 days/week, in-centre OL-HDF, significantly increases the weekly elimination of β2-microglobulin, enabling an adequate clearance of small and large uraemic toxins. |
---|---|
AbstractList | Abstract
BACKGROUND AND AIMS
Portable haemodialysis (HD) systems with a low dialysate flow rate in a short frequent schedule have become an attractive option for patients on home HD (HHD). Although these systems have been demonstrated to be effective for removing low weight molecular uraemic toxins, there are few data on their removal ability of higher molecular weight toxins. This study assessed the uraemic toxin removal ability of the portable Physidia S3 Monitor in a short, frequent, 5 days/week, low-dialysate flux HHD versus 3 days/week, in centre online haemodiafiltration (OL-HDF).
METHOD
In an open, randomized, cross-over, single-centre, controlled, prospective study, 40 adult chronic HD patients were treated by a 2.5-h low flux dialysate HD session or a 4-h post-dilution OL-HDF. All other dialysis parameters including dialyzer (polysulfone high-flux dialyzer NS 1.8, Toray®) were kept constant in both the study arms. The weekly reduction rate (RR) and the weekly eliminated mass into dialysate (EM) of urea, creatinine, phosphate, β2-microglobulin, kappa (κFLC) and lambda (λFLC) free light chains and albumin, were intra-individually compared for the two dialysis types with linear mixed models.
RESULTS
There were no significant differences in the RR for urea, phosphate, κFLC and albumin, whereas the weekly RRs for creatinine and β2-microglobulin were significantly higher with the Physidia S3 system than those obtained with OL-HDF (Table). Only the λFLC RR was significantly higher with OL-HDF. Similar results were observed when weekly EMs were compared (data not shown).
CONCLUSION
This study demonstrates that treating patients with low flow dialysate HHD in a short frequent schedule with Physidia S3 system, instead of 3 days/week, in-centre OL-HDF, significantly increases the weekly elimination of β2-microglobulin, enabling an adequate clearance of small and large uraemic toxins. |
Author | González Moya, Mercedes Pérez-Zafra, Erika Estañ, Nuria Asuncion Sancho Calabuig, Maria Molina, Pablo Montesa Marín, María García-Valdelvira, María Valero, Alejandro Vizcaíno, Belén Ventura, Josep Beltrán, Sandra Calatayud, Emma Molina, Mariola D |
Author_xml | – sequence: 1 givenname: Mercedes surname: González Moya fullname: González Moya, Mercedes organization: Doctor Peset University Hospital, Nephrology, València, Spain, University of Valencia, Medicine, València, Spain, Fisabio, València, Spain – sequence: 2 givenname: Pablo surname: Molina fullname: Molina, Pablo organization: Doctor Peset University Hospital, Nephrology, València, Spain, University of Valencia, Medicine, València, Spain, Fisabio, València, Spain – sequence: 3 givenname: Mariola D surname: Molina fullname: Molina, Mariola D organization: University of Alicante, Mathematics, San Vicente del Raspeig, Spain – sequence: 4 givenname: María surname: García-Valdelvira fullname: García-Valdelvira, María organization: Doctor Peset University Hospital, Clinical Analysis, València, Spain – sequence: 5 givenname: Belén surname: Vizcaíno fullname: Vizcaíno, Belén organization: Doctor Peset University Hospital, Nephrology, València, Spain, University of Valencia, Medicine, València, Spain, Fisabio, València, Spain – sequence: 6 givenname: María surname: Montesa Marín fullname: Montesa Marín, María organization: Doctor Peset University Hospital, Nephrology, València, Spain – sequence: 7 givenname: Josep surname: Ventura fullname: Ventura, Josep organization: Doctor Peset University Hospital, Clinical Analysis, València, Spain – sequence: 8 givenname: Erika surname: Pérez-Zafra fullname: Pérez-Zafra, Erika organization: Doctor Peset University Hospital, Clinical Analysis, València, Spain – sequence: 9 givenname: Emma surname: Calatayud fullname: Calatayud, Emma organization: Doctor Peset University Hospital, Nephrology, València, Spain, University of Valencia, Medicine, València, Spain, Fisabio, València, Spain – sequence: 10 givenname: Alejandro surname: Valero fullname: Valero, Alejandro organization: Doctor Peset University Hospital, Nephrology, València, Spain – sequence: 11 givenname: Sandra surname: Beltrán fullname: Beltrán, Sandra organization: Doctor Peset University Hospital, Nephrology, València, Spain – sequence: 12 givenname: Nuria surname: Estañ fullname: Estañ, Nuria organization: Doctor Peset University Hospital, Clinical Analysis, València, Spain – sequence: 13 givenname: Maria surname: Asuncion Sancho Calabuig fullname: Asuncion Sancho Calabuig, Maria organization: Doctor Peset University Hospital, Nephrology, València, Spain, University of Valencia, Medicine, València, Spain, Fisabio, València, Spain |
BookMark | eNotkFFPwjAcxBuDiYA--_r_AoN2Ze3GGwEUkxESQV-Xbm2hZmtNO0X8JH5ch_J0yeXucvkNUM86qxC6J3hEcEbHVrbjvRYV5nyEY3KF-mTCcBTTNOmhfpcgEU5wdoMGIbxhjLOY8z76WW8YI1NY1qYxVrTGWXAa1kbKWoGwEnLh9wpevFCNqWDnvowNYCxsD863sBCmPsHKNQpWXcJJI-pTMAGOpj1A7o6w-HNEq-DV1R-NmsIMnrth15hvJWHuXQjuU3mY18aaStSw813lFl1rUQd1d9Eh2j4sd_NVlG8en-azPKp4QqIyJiXDGS-x5DjVpaaSpCWjTKeakypJpWSxqJiQMlYUq5gKxUU14ROmGI_pEI3_V6vzDa908e5NI_ypILg4Yy06rMUFa9Fhpb8wMHBW |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.1093/ndt/gfac077.021 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1460-2385 |
ExternalDocumentID | 10_1093_ndt_gfac077_021 |
GroupedDBID | --- -E4 .2P .I3 .XZ .ZR 0R~ 123 18M 1TH 29M 2WC 4.4 482 48X 53G 5RE 5VS 5WA 5WD 70D AABZA AACZT AAHTB AAJKP AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUAY AAVAP AAYXX ABEUO ABIXL ABJNI ABKDP ABNHQ ABNKS ABOCM ABPEJ ABPTD ABQLI ABQNK ABWST ABXVV ABZBJ ACGFO ACGFS ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIAGR AIJHB AJEEA AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CITATION CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS EE~ ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IOX J21 JXSIZ KAQDR KOP KQ8 KSI KSN M-Z M49 MHKGH ML0 N9A NGC NOMLY NOYVH NU- O9- OAUYM OAWHX OCZFY ODMLO OHH OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PEELM PQQKQ Q1. Q5Y R44 RD5 ROL ROX ROZ RUSNO RW1 RXO SDH TCURE TEORI TJX TR2 W8F WH7 WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 |
ID | FETCH-LOGICAL-c751-b21b6097b0d708fbf3d18b636f8f71c58dd62ac6add2e30e23ae7ac4746e6723 |
ISSN | 0931-0509 |
IngestDate | Thu Sep 12 17:53:20 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Supplement_3 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c751-b21b6097b0d708fbf3d18b636f8f71c58dd62ac6add2e30e23ae7ac4746e6723 |
ParticipantIDs | crossref_primary_10_1093_ndt_gfac077_021 |
PublicationCentury | 2000 |
PublicationDate | 2022-05-03 |
PublicationDateYYYYMMDD | 2022-05-03 |
PublicationDate_xml | – month: 05 year: 2022 text: 2022-05-03 day: 03 |
PublicationDecade | 2020 |
PublicationTitle | Nephrology, dialysis, transplantation |
PublicationYear | 2022 |
SSID | ssj0009277 |
Score | 2.4168086 |
Snippet | Abstract
BACKGROUND AND AIMS
Portable haemodialysis (HD) systems with a low dialysate flow rate in a short frequent schedule have become an attractive option... |
SourceID | crossref |
SourceType | Aggregation Database |
Title | MO661: Elimination of Middle and Large Uraemic Toxins in Short Daily Home Haemodialysis with Low Dialysate Volume: A Randomized Crossover Clinical Trial |
Volume | 37 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF5FRUJcUHmJt-bAASly6-eu3VvVV4C6SDSterN27XWJZOwqSgXkl_A3-QfM7NqOA0UqXCxrs5rYmS87s7PfzDD2Rugkj6SbOKosQidElDiJ9LQj6YhJeoVyNeU7pyd8cha-v4guRqOfA9bS9UJt5csb80r-R6s4hnqlLNl_0GwvFAfwHvWLV9QwXm-l4_Qj2j3a0x9UpjlX5_2lJupgzgWOiek9PptLQ4KfNt9mljl--hn9btQ5RTeoVfp4gjMayiIxJUpMePa4-YpLIo2gQzo-N-uYzWT_hKKbL7MlhYfJzBIPdLzXJVlO6dWHXu-JRsj0aTHdl9D9wtRWr2S9zgg4auqlOcL3Kr3Edee7cXFTIuEUK9JjahoOWT9YVc2fw6mcz3DrvmI1H-Hf2sjdl865rApdEce5ndp-MIyD4BaaWIfBMKAZeA5Vs7GWzS7nIXcddEqi4Xpvi8y0uDa9U00gNgtutCi22lZdoEk8vCxl7gqx5dqk7vXq3b9Z1Z7raE_5gwxFZK2AzKXSB3d8kUQUL9h_92FVJ9o3zUL7l-mqUSXBNgrYHjzBwJEaeETTTXa_3crArsXlAzbS9UN2N23JGo_YDwPPHRiAE5oSLDgBEQQGnNCCEyw4YVaDAScYcAKBE9bACQROQHBCD06w4NyBXVhBE3poQgdNMNB8zE4PD6Z7E6dtBOLkIvIc5XuKu4lQbiHcuFRlUHix4gEv41J4eRQXBfdlztFU-zpwtR9ILWQeipBrLvzgCduom1o_ZVDqXFG9odyXRZgHPI6l72vuq1jIuPS8Z-xt95tmV7baS_YX_T2__dQX7N4KsC_ZxmJ-rV-hK7tQr43yfwFwWaP9 |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MO661%3A+Elimination+of+Middle+and+Large+Uraemic+Toxins+in+Short+Daily+Home+Haemodialysis+with+Low+Dialysate+Volume%3A+A+Randomized+Crossover+Clinical+Trial&rft.jtitle=Nephrology%2C+dialysis%2C+transplantation&rft.au=Gonz%C3%A1lez+Moya%2C+Mercedes&rft.au=Molina%2C+Pablo&rft.au=Molina%2C+Mariola+D&rft.au=Garc%C3%ADa-Valdelvira%2C+Mar%C3%ADa&rft.date=2022-05-03&rft.issn=0931-0509&rft.eissn=1460-2385&rft.volume=37&rft.issue=Supplement_3&rft_id=info:doi/10.1093%2Fndt%2Fgfac077.021&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_ndt_gfac077_021 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0931-0509&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0931-0509&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0931-0509&client=summon |