Hepatitis E Virus Infection in Central China Reveals No Evidence of Cross-Species Transmission between Human and Swine in This Area

• Published in: PloS one Vol. 4; no. 12; p. e8156
• Main Authors: Zhang, Wen, Yang, Shixing, Ren, Liping, Shen, Quan, Cui, Li, Fan, Kezhang, Huang, Fen, Kang, Yanjun, Shan, Tongling, Wei, Jianzhong, Xiu, Haifeng, Lou, Yifang, Liu, Junfeng, Yang, Zhibiao, Zhu, Jianguo, Hua, Xiuguo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.12.2009; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Aged; Amino acid sequence; Analysis; Animal populations; animal production; Animal species; Animals; Antibodies, Viral; Antibodies, Viral - immunology; Biology; Capsid protein; Child; Child, Preschool; China; China - epidemiology; Cladistic analysis; Cloning; Clustering; coat proteins; cross reaction; Disease transmission; Enzyme-linked immunosorbent assay; Epidemics; Epidemiology; Farms; Female; genes; Genetic relationship; genetics; Genotype & phenotype; Hepatitis; Hepatitis E; Hepatitis E - epidemiology; Hepatitis E - transmission; Hepatitis E - virology; Hepatitis E virus; Hepatitis E virus - genetics; Hepatitis E virus - immunology; Hepatitis E virus - physiology; Humans; Immunoblotting; immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; immunology; Infection; Infections; Infectious Diseases/Viral Infections; Life sciences; Livestock; Livestock farms; Male; metabolism; Middle Aged; nucleotide sequences; Orthohepevirus A; Phylogeny; physiology; Populations; Public Health and Epidemiology/Infectious Diseases; Reverse transcription; RNA, Viral; RNA, Viral - metabolism; Rural areas; Sequence Analysis, DNA; Seroepidemiology; seroprevalence; Species; Species Specificity; strain differences; Strains (organisms); Swine; Swine - virology; Transcription (Genetics); transmission; viral hepatitis; Viral proteins; virology; Virology/Emerging Viral Diseases; Viruses; Young Adult; Zoonoses; China

Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs. Swine stands out as the major reservoir for HEV infection in humans, as suggested by the close genetic relationship of swine and human virus. Since 2000, Genotype 4 HEV has become the domin...