Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus
The cascade of events that leads to vaccinia-induced actin polymerization requires Src-dependent tyrosine phosphorylation of the viral membrane protein A36R. We found that a localized outside-in signaling cascade induced by the viral membrane protein B5R is required to potently activate Src and indu...
Saved in:
Published in | Science (American Association for the Advancement of Science) Vol. 306; no. 5693; pp. 124 - 129 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Association for the Advancement of Science
01.10.2004
The American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The cascade of events that leads to vaccinia-induced actin polymerization requires Src-dependent tyrosine phosphorylation of the viral membrane protein A36R. We found that a localized outside-in signaling cascade induced by the viral membrane protein B5R is required to potently activate Src and induce A36R phosphorylation at the plasma membrane. In addition, Src-mediated phosphorylation of A36R regulated the ability of virus particles to recruit and release conventional kinesin. Thus, Src activity regulates the transition between cytoplasmic microtubule transport and actin-based motility at the plasma membrane. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.1101509 |