Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

• Published in: Cell and tissue research Vol. 346; no. 3; pp. 393 - 405
• Main Authors: Riva, Matteo, Nitert, Marloes Dekker, Voss, Ulrikke, Sathanoori, Ramasri, Lindqvist, Andreas, Ling, Charlotte, Wierup, Nils
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.12.2011; Springer; Springer Nature B.V
• Subjects: adipocytes; Animals; Biologi; Biological Sciences; Biomedical and Life Sciences; Biomedicine; biosynthesis; brain; Calcium-Binding Proteins; Calcium-Binding Proteins - biosynthesis; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell Biology; Cellbiologi; Cellular biology; Dextrose; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; DNA-Binding Proteins; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; drug effects; Female; Gene expression; gene expression regulation; genetics; ghrelin; Glucagon; Glucagon - genetics; Glucagon - metabolism; Glucose; Glucose metabolism; Glucose tolerance tests; Human Genetics; Humans; immunocytochemistry; Immunohistochemistry; in situ hybridization; Insulin; Insulin - genetics; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; islets of Langerhans; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Male; messenger RNA; metabolism; Mice; Mice, Inbred C57BL; microarray technology; Molecular Medicine; Natural Sciences; Naturvetenskap; Nerve Tissue Proteins; Nerve Tissue Proteins - biosynthesis; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; noninsulin-dependent diabetes mellitus; Pancreatic beta cells; Peptides; physiopathology; Proteomics; Rats; Rats, Sprague-Dawley; Regular Article; RNA; Rodents; secretion; Type 2 diabetes; Western blotting; Human islets; In situ hybridization; Immunochemistry; Regulatory peptide; Rodent islets

Nesfatin-1 is a novel anorexigenic regulatory peptide. The peptide is the N-terminal part of nucleobindin 2 (NUCB2) and is expressed in brain areas regulating feeding. Outside the brain, nesfatin-1 expression has been reported in adipocytes, gastric endocrine cells and islet cells. We studied NUCB2...