Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers

• Published in: PloS one Vol. 5; no. 5; p. e10815
• Main Authors: Tomasi, Dardo, Volkow, Nora D., Wang, Ruiliang, Carrillo, Jean H., Maloney, Thomas, Alia-Klein, Nelly, Woicik, Patricia A., Telang, Frank, Goldstein, Rita Z.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.05.2010; Public Library of Science (PLoS)
• Subjects: Achievement tests; Activation; Addicts; Adult; Alcoholism; Attention task; BASIC BIOLOGICAL SCIENCES; Behavior - physiology; BRAIN; Brain Mapping; Brain research; CEREBELLUM; Cigarettes; COCAINE; Cocaine-Related Disorders - physiopathology; Comparative analysis; Cortex; DEACTIVATION; DOPAMINE; Dopamine - metabolism; Dopamine receptors; dopamineric; Drug abuse; Drug dosages; Education; Female; Functional magnetic resonance imaging; FUNCTIONALS; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; Humans; HYPOTHESIS; Laboratories; Magnetic Resonance Imaging; Male; Mental Health/Neuropsychiatric Disorders; Mesencephalon; Mesencephalon - physiopathology; midbrain; Motivation; Narcotics; NERVE CELLS; Nerve Net - physiopathology; Neural networks; Neurological Disorders/Neuroimaging; Neurons; Neurotransmission; Nicotine; NMR; Nuclear magnetic resonance; Psychopharmacology; Radiology and Medical Imaging/Magnetic Resonance Imaging; Reinforcement; Standard scores; Task Performance and Analysis; THALAMUS; Thalamus - physiopathology; Toxicology; Urine; Validation studies; New York; United States > US; Maryland

Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivit...