Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers

Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivit...

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Published inPloS one Vol. 5; no. 5; p. e10815
Main Authors Tomasi, Dardo, Volkow, Nora D., Wang, Ruiliang, Carrillo, Jean H., Maloney, Thomas, Alia-Klein, Nelly, Woicik, Patricia A., Telang, Frank, Goldstein, Rita Z.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.05.2010
Public Library of Science (PLoS)
Subjects
Achievement tests
Activation
Addicts
Adult
Alcoholism
Attention task
BASIC BIOLOGICAL SCIENCES
Behavior - physiology
BRAIN
Brain Mapping
Brain research
CEREBELLUM
Cigarettes
COCAINE
Cocaine-Related Disorders - physiopathology
Comparative analysis
Cortex
DEACTIVATION
DOPAMINE
Dopamine - metabolism
Dopamine receptors
dopamineric
Drug abuse
Drug dosages
Education
Female
Functional magnetic resonance imaging
FUNCTIONALS
GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
Humans
HYPOTHESIS
Laboratories
Magnetic Resonance Imaging
Male
Mental Health/Neuropsychiatric Disorders
Mesencephalon
Mesencephalon - physiopathology
midbrain
Motivation
Narcotics
NERVE CELLS
Nerve Net - physiopathology
Neural networks
Neurological Disorders/Neuroimaging
Neurons
Neurotransmission
Nicotine
NMR
Nuclear magnetic resonance
Psychopharmacology
Radiology and Medical Imaging/Magnetic Resonance Imaging
Reinforcement
Standard scores
Task Performance and Analysis
THALAMUS
Thalamus - physiopathology
Toxicology
Urine
Validation studies
New York
United States > US
Maryland
Online AccessGet full text

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Abstract Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
AbstractList Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
Background Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. Methodology/Principal Findings We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. Conclusions/Significance These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
Background Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task. Methodology/Principal Findings We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate. Conclusions/Significance These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task.BACKGROUNDChronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) is yet to be fully investigated. Here we test the hypothesis that cocaine addicted subjects will have disrupted functional connectivity between the midbrain (where dopamine neurons are located) and cortical and subcortical brain regions during the performance of a sustained attention task.We measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate.METHODOLOGY/PRINCIPAL FINDINGSWe measured brain activation and functional connectivity with fMRI in 20 cocaine abusers and 20 matched controls. When compared to controls, cocaine abusers had lower positive functional connectivity of midbrain with thalamus, cerebellum, and rostral cingulate, and this was associated with decreased activation in thalamus and cerebellum and enhanced deactivation in rostral cingulate.These findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.CONCLUSIONS/SIGNIFICANCEThese findings suggest that decreased functional connectivity of the midbrain interferes with the activation and deactivation signals associated with sustained attention in cocaine addicts.
Audience Academic
Author Goldstein, Rita Z.
Carrillo, Jean H.
Volkow, Nora D.
Alia-Klein, Nelly
Wang, Ruiliang
Woicik, Patricia A.
Tomasi, Dardo
Telang, Frank
Maloney, Thomas
AuthorAffiliation 4 Computer Science Department, SUNY at Stony Brook, Stony Brook, New York, United States of America
1 National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
2 National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, United States of America
3 Medical Department, Brookhaven National Laboratory, Upton, New York, United States of America
Cuban Neuroscience Center, Cuba
AuthorAffiliation_xml – name: Cuban Neuroscience Center, Cuba
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– name: 1 National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
– name: 4 Computer Science Department, SUNY at Stony Brook, Stony Brook, New York, United States of America
– name: 2 National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, United States of America
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  surname: Maloney
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/20520835$$D View this record in MEDLINE/PubMed
https://www.osti.gov/biblio/1014310$$D View this record in Osti.gov
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Conceived and designed the experiments: DT NDV RZG. Performed the experiments: DT RW TM NAK PAW FT RZG. Analyzed the data: DT JFH RZG. Contributed reagents/materials/analysis tools: DT. Wrote the paper: DT NDV RZG.
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Snippet Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than...
Background Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than...
Background Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than...
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SubjectTerms Achievement tests
Activation
Addicts
Adult
Alcoholism
Attention task
BASIC BIOLOGICAL SCIENCES
Behavior - physiology
BRAIN
Brain Mapping
Brain research
CEREBELLUM
Cigarettes
COCAINE
Cocaine-Related Disorders - physiopathology
Comparative analysis
Cortex
DEACTIVATION
DOPAMINE
Dopamine - metabolism
Dopamine receptors
dopamineric
Drug abuse
Drug dosages
Education
Female
Functional magnetic resonance imaging
FUNCTIONALS
GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
Humans
HYPOTHESIS
Laboratories
Magnetic Resonance Imaging
Male
Mental Health/Neuropsychiatric Disorders
Mesencephalon
Mesencephalon - physiopathology
midbrain
Motivation
Narcotics
NERVE CELLS
Nerve Net - physiopathology
Neural networks
Neurological Disorders/Neuroimaging
Neurons
Neurotransmission
Nicotine
NMR
Nuclear magnetic resonance
Psychopharmacology
Radiology and Medical Imaging/Magnetic Resonance Imaging
Reinforcement
Standard scores
Task Performance and Analysis
THALAMUS
Thalamus - physiopathology
Toxicology
Urine
Validation studies
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Title Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers
URI https://www.ncbi.nlm.nih.gov/pubmed/20520835
https://www.proquest.com/docview/1292137879
https://www.proquest.com/docview/733142999
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https://www.osti.gov/biblio/1014310
https://pubmed.ncbi.nlm.nih.gov/PMC2876035
https://doaj.org/article/cde5693dc2de4a739c98932d6d769e5d
http://dx.doi.org/10.1371/journal.pone.0010815
Volume 5
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