Increased gray matter volume of the basal ganglia – a morphometric fingerprint of presymptomatic compensation in genetically determined parkinsonism

• Published in: Klinische Neurophysiologie
• Main Authors: Lasek, K, Klein, C, Gaser, C, Hilker, R, Hagenah, J, van Eimeren, T, Büchel, C, Pramstaller, P, Siebner, H, Binkofski, F
• Format: Conference Proceeding
• Language: English; German
• Published: 24.03.2006

Objectives: There is little knowledge about in vivo changes in the human brain that precede the onset of parkinsonism. The present study used voxel-based morphometry (VBM) to investigate brain tissue changes in asymptomatic carriers of heterozygous mutations in Parkin- and PINK1-genes, and 18F-DOPA...