Genome evolution in the allotetraploid frog Xenopus laevis

• Published in: Nature (London) Vol. 538; no. 7625; pp. 336 - 343
• Main Authors: Session, Adam M., Uno, Yoshinobu, Kwon, Taejoon, Chapman, Jarrod A., Toyoda, Atsushi, Takahashi, Shuji, Fukui, Akimasa, Hikosaka, Akira, Suzuki, Atsushi, Kondo, Mariko, van Heeringen, Simon J., Quigley, Ian, Heinz, Sven, Ogino, Hajime, Ochi, Haruki, Hellsten, Uffe, Lyons, Jessica B., Simakov, Oleg, Putnam, Nicholas, Stites, Jonathan, Kuroki, Yoko, Tanaka, Toshiaki, Michiue, Tatsuo, Watanabe, Minoru, Bogdanovic, Ozren, Lister, Ryan, Georgiou, Georgios, Paranjpe, Sarita S., van Kruijsbergen, Ila, Shu, Shengquiang, Carlson, Joseph, Kinoshita, Tsutomu, Ohta, Yuko, Mawaribuchi, Shuuji, Jenkins, Jerry, Grimwood, Jane, Schmutz, Jeremy, Mitros, Therese, Mozaffari, Sahar V., Suzuki, Yutaka, Haramoto, Yoshikazu, Yamamoto, Takamasa S., Takagi, Chiyo, Heald, Rebecca, Miller, Kelly, Haudenschild, Christian, Kitzman, Jacob, Nakayama, Takuya, Izutsu, Yumi, Robert, Jacques, Fortriede, Joshua, Burns, Kevin, Lotay, Vaneet, Karimi, Kamran, Yasuoka, Yuuri, Dichmann, Darwin S., Flajnik, Martin F., Houston, Douglas W., Shendure, Jay, DuPasquier, Louis, Vize, Peter D., Zorn, Aaron M., Ito, Michihiko, Marcotte, Edward M., Wallingford, John B., Ito, Yuzuru, Asashima, Makoto, Ueno, Naoto, Matsuda, Yoichi, Veenstra, Gert Jan C., Fujiyama, Asao, Harland, Richard M., Taira, Masanori, Rokhsar, Daniel S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2016; Nature Publishing Group
• Subjects: 38/91; 45/23; 45/71; 49/15; 49/39; 631/181/735; 631/208/212/2304; 64/114; Amphibians; Animals; Artificial chromosomes; BASIC BIOLOGICAL SCIENCES; Chromosomes - genetics; Conserved Sequence - genetics; Deoxyribonucleic acid; Diploidy; DNA; DNA methylation; DNA Transposable Elements - genetics; Epigenetics; Evolution, Molecular; Female; Frogs; Gene Deletion; Gene expression; Gene Expression Profiling; Genome - genetics; Genome evolution; Genomes; Humanities and Social Sciences; Karyotype; Molecular evolution; Molecular Sequence Annotation; multidisciplinary; Mutagenesis - genetics; Phylogeny; Physiological aspects; Polyploidy; Proteins; Pseudogenes; Science; Tetraploidy; Xenopus - genetics; Xenopus laevis - genetics

To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome. We characterize the allotetraploid origin of X. laevis by partitioning its genome into two homoeologous subgenomes, m...