Long-term exposure to diesel engine exhaust induced lung function decline in a cross sectional study

To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index...

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Published inIndustrial Health Vol. 55; no. 1; pp. 13 - 26
Main Authors NIU, Yong, YU, Shan Fa, DUAN, Hua Wei, MENG, Tao, HUANG, Chuan Feng, GAO, Wei Min, ZHENG, Yu Xin, ZHANG, Li Ping, ZHANG, Xiao
Format Journal Article
LanguageEnglish
Published Japan National Institute of Occupational Safety and Health 01.01.2017
National Institute of Occupational Safety and Health, Japan
Subjects
Adult
Cross-Sectional Studies
Cytokinesis
Diesel engine exhaust
Gasoline - adverse effects
Humans
Long-term exposure
Lung - physiopathology
Lung function
Male
Micronucleus Tests
Occupational Exposure - adverse effects
Original
Polycyclic Aromatic Hydrocarbons - urine
Respiratory Function Tests
The cytokinesis-block micronucleus cytome index
Urinary mono-hydroxylated polycyclic aromatic hydrocarbons
Vehicle Emissions - poisoning
Vital Capacity
Young Adult
Online AccessGet full text
ISSN0019-8366
1880-8026
DOI10.2486/indhealth.2016-0031

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Abstract To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV1), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/ FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF50%), and forced expiratory flow at 75% of FVC (FEF75%) in the DEE-exposed workers than non-DEE-exposed workers (all p<0.05). Among all study subjects, the decreases of FEF75% were associated with the increasing levels of PAHs meta­bolites (p<0.05), and there were negative correlations between FEV1, FEV1/FVC, MMF, FEF50%, and FEF75% with CBMN cytome index (all p<0.05). Our results show that long-term exposure to DEE can induce lung function decline which shows mainly obstructive changes and influence of small airways function. The decreased lung function is associated with internal dosage of DEE exposure, and accompany with the increasing CBMN cytome index.
AbstractList To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV 1 ), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV 1 / FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF 50% ), and forced expiratory flow at 75% of FVC (FEF 75% ) in the DEE-exposed workers than non-DEE-exposed workers (all p <0.05). Among all study subjects, the decreases of FEF 75% were associated with the increasing levels of PAHs metabolites ( p <0.05), and there were negative correlations between FEV 1 , FEV 1 /FVC, MMF, FEF 50% , and FEF 75% with CBMN cytome index (all p <0.05). Our results show that long-term exposure to DEE can induce lung function decline which shows mainly obstructive changes and influence of small airways function. The decreased lung function is associated with internal dosage of DEE exposure, and accompany with the increasing CBMN cytome index.
To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV sub(1)), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV sub(1)/ FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF sub(50%)), and forced expiratory flow at 75% of FVC (FEF sub(75%)) in the DEE-exposed workers than non-DEE-exposed workers (all p<0.05). Among all study subjects, the decreases of FEF sub(75%) were associated with the increasing levels of PAHs meta-bolites (p<0.05), and there were negative correlations between FEV sub(1), FEV sub(1)/FVC, MMF, FEF sub(50%), and FEF sub(75%) with CBMN cytome index (all p<0.05). Our results show that long-term exposure to DEE can induce lung function decline which shows mainly obstructive changes and influence of small airways function. The decreased lung function is associated with internal dosage of DEE exposure, and accompany with the increasing CBMN cytome index.
To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV ), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV / FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF ), and forced expiratory flow at 75% of FVC (FEF ) in the DEE-exposed workers than non-DEE-exposed workers (all p<0.05). Among all study subjects, the decreases of FEF were associated with the increasing levels of PAHs meta-bolites (p<0.05), and there were negative correlations between FEV , FEV /FVC, MMF, FEF , and FEF with CBMN cytome index (all p<0.05). Our results show that long-term exposure to DEE can induce lung function decline which shows mainly obstructive changes and influence of small airways function. The decreased lung function is associated with internal dosage of DEE exposure, and accompany with the increasing CBMN cytome index.
To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV1), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/ FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF50%), and forced expiratory flow at 75% of FVC (FEF75%) in the DEE-exposed workers than non-DEE-exposed workers (all p<0.05). Among all study subjects, the decreases of FEF75% were associated with the increasing levels of PAHs meta­bolites (p<0.05), and there were negative correlations between FEV1, FEV1/FVC, MMF, FEF50%, and FEF75% with CBMN cytome index (all p<0.05). Our results show that long-term exposure to DEE can induce lung function decline which shows mainly obstructive changes and influence of small airways function. The decreased lung function is associated with internal dosage of DEE exposure, and accompany with the increasing CBMN cytome index.
Audience Academic
Author GAO, Wei Min
HUANG, Chuan Feng
ZHANG, Li Ping
ZHANG, Xiao
ZHENG, Yu Xin
MENG, Tao
YU, Shan Fa
NIU, Yong
DUAN, Hua Wei
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Snippet To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and...
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pubmed
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StartPage 13
SubjectTerms Adult
Cross-Sectional Studies
Cytokinesis
Diesel engine exhaust
Gasoline - adverse effects
Humans
Long-term exposure
Lung - physiopathology
Lung function
Male
Micronucleus Tests
Occupational Exposure - adverse effects
Original
Polycyclic Aromatic Hydrocarbons - urine
Respiratory Function Tests
The cytokinesis-block micronucleus cytome index
Urinary mono-hydroxylated polycyclic aromatic hydrocarbons
Vehicle Emissions - poisoning
Vital Capacity
Young Adult
Title Long-term exposure to diesel engine exhaust induced lung function decline in a cross sectional study
URI https://www.jstage.jst.go.jp/article/indhealth/55/1/55_2016-0031/_article/-char/en
https://www.ncbi.nlm.nih.gov/pubmed/27334424
https://www.proquest.com/docview/1881759263
https://pubmed.ncbi.nlm.nih.gov/PMC5285310
Volume 55
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