Diversity and dynamics of the Drosophila transcriptome

• Published in: Nature (London) Vol. 512; no. 7515; pp. 393 - 399
• Main Authors: Brown, James B., Boley, Nathan, Eisman, Robert, May, Gemma E., Stoiber, Marcus H., Duff, Michael O., Booth, Ben W., Wen, Jiayu, Park, Soo, Suzuki, Ana Maria, Wan, Kenneth H., Yu, Charles, Zhang, Dayu, Carlson, Joseph W., Cherbas, Lucy, Eads, Brian D., Miller, David, Mockaitis, Keithanne, Roberts, Johnny, Davis, Carrie A., Frise, Erwin, Hammonds, Ann S., Olson, Sara, Shenker, Sol, Sturgill, David, Samsonova, Anastasia A., Weiszmann, Richard, Robinson, Garret, Hernandez, Juan, Andrews, Justen, Bickel, Peter J., Carninci, Piero, Cherbas, Peter, Gingeras, Thomas R., Hoskins, Roger A., Kaufman, Thomas C., Lai, Eric C., Oliver, Brian, Perrimon, Norbert, Graveley, Brenton R., Celniker, Susan E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.08.2014; Nature Publishing Group
• Subjects: 14; 38; 38/39; 45/91; 631/114/2401; 631/208/191/2018; 631/208/212; 631/208/212/2019; 64/24; Alternative Splicing - genetics; Analysis; Animals; Developmental stages; Drosophila; Drosophila melanogaster - anatomy & histology; Drosophila melanogaster - cytology; Drosophila melanogaster - genetics; Female; Gene Expression Profiling; Genes; Genetic aspects; Genetic research; Genetic transcription; Genomes; Genomics; Gonads; Humanities and Social Sciences; Insects; Male; Methods; Molecular Sequence Annotation; multidisciplinary; Nerve Tissue - metabolism; Organ Specificity; Poly A - genetics; Polyadenylation; Promoter Regions, Genetic - genetics; Proteins; RNA; RNA, Long Noncoding - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Sex Characteristics; Stress, Physiological - genetics; Transcriptome - genetics

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing an ensemble of transcript isoforms that give rise to substantial diversity. Here we have identified new genes, transcripts and proteins using poly(A) + RNA sequencing from Drosophila melanogaster in cultured c...