A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia
The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fu...
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Published in | Science (American Association for the Advancement of Science) Vol. 278; no. 5341; pp. 1309 - 1312 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for the Advancement of Science
14.11.1997
American Association for the Advancement of Science The American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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