Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum
•Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum.•Robust changes in cBF volume and diffusivity in MCI and AD dementia.•Only minimal changes in cBF functional connectivity across the AD spectrum.•No imaging modality detects significant cBF changes in subjective cog...
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| Published in | NeuroImage clinical Vol. 28; p. 102495 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.01.2020
Elsevier BV Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2213-1582 2213-1582 |
| DOI | 10.1016/j.nicl.2020.102495 |
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| Abstract | •Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum.•Robust changes in cBF volume and diffusivity in MCI and AD dementia.•Only minimal changes in cBF functional connectivity across the AD spectrum.•No imaging modality detects significant cBF changes in subjective cognitive decline.•Similar results in subset analysis of patients with biomarker-confirmed Aβ-pathology.
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes.
Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants.
a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results.
We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry. |
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| AbstractList | •
Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum.
•
Robust changes in cBF volume and diffusivity in MCI and AD dementia.
•
Only minimal changes in cBF functional connectivity across the AD spectrum.
•
No imaging modality detects significant cBF changes in subjective cognitive decline.
•
Similar results in subset analysis of patients with biomarker-confirmed Aβ-pathology. Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes.BACKGROUNDDysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes.Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants.METHODSParticipants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants.a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results.RESULTSa-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results.We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry.CONCLUSIONSWe reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry. Background: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Methods: Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants. Results: a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results. Conclusions: We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry. •Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum.•Robust changes in cBF volume and diffusivity in MCI and AD dementia.•Only minimal changes in cBF functional connectivity across the AD spectrum.•No imaging modality detects significant cBF changes in subjective cognitive decline.•Similar results in subset analysis of patients with biomarker-confirmed Aβ-pathology. Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants. a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results. We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry. Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants. a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results. We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry. Highlights•Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum. •Robust changes in cBF volume and diffusivity in MCI and AD dementia. •Only minimal changes in cBF functional connectivity across the AD spectrum. •No imaging modality detects significant cBF changes in subjective cognitive decline. •Similar results in subset analysis of patients with biomarker-confirmed Aβ-pathology. |
| ArticleNumber | 102495 |
| Author | Herdick, Meret Ertl-Wagner, Birgit Buerger, Katharina Scheffler, Klaus Dylan Haynes, John Teipel, Stefan Metzger, Coraline D. Peters, Oliver Spottke, Annika Schneider, Anja Grothe, Michel J. Ballarini, Tommaso Fliessbach, Klaus Glanz, Wenzel Priller, Josef Dobisch, Laura Duezel, Emrah Laske, Christoph Dechent, Peter Janowitz, Daniel Can Cetindag, Arda Altenstein, Slawek Kilimann, Ingo Roy, Nina Dawn Freiesleben, Silka Tscheuschler, Maike Brosseron, Frederic Fritz, Hans-Christian J. Jakob Spruth, Eike Vukovich, Ruth Jessen, Frank Munk, Matthias H. Heneka, Michael T. Wiltfang, Jens Frommann, Ingo Dyrba, Martin |
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| BackLink | https://cir.nii.ac.jp/crid/1871709543097330048$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/33395986$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3389/fnagi.2017.00109 10.1007/s00401-015-1392-5 10.1007/s10072-012-1225-4 10.1007/s13670-018-0234-4 10.1016/j.jalz.2014.01.001 10.1002/cne.902140206 10.1212/WNL.34.6.741 10.1212/WNL.55.4.484 10.1093/brain/awy072 10.1002/ana.10069 10.3233/JAD-132345 10.3389/fnsys.2010.00013 10.1002/mrm.1910350312 10.1016/j.neuroimage.2005.12.033 10.1016/j.neurobiolaging.2013.09.029 10.1002/mrm.22818 10.1038/ncomms13249 10.1016/j.biopsych.2009.02.026 10.1016/S0197-4580(03)00084-8 10.1089/brain.2013.0144 10.1016/j.bbr.2008.08.012 10.1016/j.neuroimage.2016.12.077 10.1016/j.pscychresns.2011.05.012 10.1016/j.biopsych.2011.06.019 10.1017/S1041610216002349 10.1002/acn3.274 10.1186/s13195-017-0314-2 10.1002/ana.410100203 10.1002/mrm.1910340409 10.1016/j.neurobiolaging.2006.01.009 10.1016/j.nicl.2014.11.015 10.1002/(SICI)1096-9861(19990906)411:4<693::AID-CNE13>3.0.CO;2-D 10.3233/JAD-190446 10.1148/radiol.2018180268 10.1016/j.jalz.2011.03.008 10.1126/science.7058341 10.1007/s00406-014-0496-6 10.1016/j.jalz.2008.04.006 10.1212/WNL.0000000000010192 10.1016/j.nicl.2018.101612 10.1016/j.jalz.2011.03.005 10.1212/WNL.52.7.1397 10.3233/JAD-180106 10.3233/JAD-150063 10.1002/hbm.24417 10.1016/j.nec.2010.11.001 10.1016/j.jalz.2013.09.011 10.1016/j.neuroimage.2007.07.007 10.3389/fnagi.2017.00127 10.1007/s00415-019-09429-3 10.1016/j.nicl.2017.10.005 10.1006/jmrb.1994.1037 |
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| Copyright | 2020 The Authors The Authors Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. 2020 The Authors 2020 |
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| Keywords | AD Cholinergic Basal Forebrain Alzheimer’s Disease cBF GM Mean Diffusivity MCI dACC Functional Connectivity SCD WM MD Subjective Cognitive Decline DTI NBM Resting-state fMRI FC dorsal anterior cingulate cholinergic basal forebrain white matter functional connectivity subjective cognitive decline nucleus basilis of Meynert gray matter diffusion tensor imaging mild cognitive impairment mean diffusity |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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| References | Jack, Petersen, Xu, O'Brien, Smith, Ivnik, Boeve, Tangalos, Kokmen (b0100) 2000; 55 Muth, Schönmeyer, Matura, Haenschel, Schröder, Pantel (b0175) 2010; 67 Teipel, Heinsen, Amaro, Grinberg, Krause, Grothe (b0205) 2014; 35 Müller, Greverus, Weibrich, Dellani, Scheurich, Stoeter, Fellgiebel (b0170) 2007; 28 Pennanen, Kivipelto, Tuomainen, Hartikainen, Hänninen, Laakso, Hallikainen, Vanhanen, Nissinen, Helkala, Vainio, Vanninen, Partanen, Soininen (b0180) 2004; 25 DeKosky, Ikonomovic, Styren, Beckett, Wisniewski, Bennett, Cochran, Kordower, Mufson (b0045) 2002; 51 Fritz, Ray, Dyrba, Sorg, Teipel, Grothe (b0055) 2019; 40 Gonzalez-Escamilla, Lange, Teipel, Buchert, Grothe (b0070) 2017; 147 Teipel, Metzger, Brosseron, Buerger, Brueggen, Catak, Diesing, Dobisch, Fliebach, Franke, Heneka, Kilimann, Kofler, Menne, Peters, Polcher, Priller, Schneider, Spottke, Spruth, Thelen, Thyrian, Wagner, Düzel, Jessen, Dyrba (b0220) 2018; 64 McGeer, McGeer, Suzuki, Dolman, Nagai (b0155) 1984; 34 Ryu, Lim, Na, Shim, Cho, Yoon, Hong, Yang (b0185) 2017; 29 Basser, Mattiello, Lebihan (b0015) 1994; 103 Gilmor, Erickson, Varoqui, Hersh, Bennett, Cochran, Mufson, Levey (b0060) 1999; 411 Mesulam, Mufson, Levey, Wainer (b0165) 1983; 214 Liu, Chang, Pearce, Gentleman (b0145) 2015; 129 Brueggen, Dyrba, Barkhof, Hausner, Filippi, Nestor, Hauenstein, Klöppel, Grothe, Kasper, Teipel (b0030) 2015; 48 Friston, Williams, Howard, Frackowiak, Turner (b0050) 1996; 35 Teipel, Fritz, Grothe (b0210) 2020 Wang, Zang, He, Liang, Zhang, Tian, Wu, Jiang, Li (b0240) 2006; 31 Brueggen, Dyrba, Cardenas-Blanco, Schneider, Fliessbach, Buerger, Janowitz, Peters, Menne, Priller, Spruth, Wiltfang, Vukovich, Laske, Buchmann, Wagner, Röske, Spottke, Rudolph, Metzger, Kilimann, Dobisch, Düzel, Jessen, Teipel (b0035) 2019; 266 Ashburner (b0010) 2007; 38 McKhann, Knopman, Chertkow, Hyman, Jack, Kawas, Klunk, Koroshetz, Manly, Mayeux, Mohs, Morris, Rossor, Scheltens, Carrillo, Thies, Weintraub, Phelps (b0160) 2011; 7 Teipel, Walter, Likitjaroen, Schönknecht, Gruber (b0230) 2014; 264 Albert, DeKosky, Dickson, Dubois, Feldman, Fox, Gamst, Holtzman, Jagust, Petersen, Snyder, Carrillo, Thies, Phelps (b0005) 2011; 7 Kerbler, Fripp, Rowe, Villemagne, Salvado, Rose, Coulson (b0130) 2015; 7 Hong, Yoon, Lim, Shim, Kim, Ahn, Han, Yang (b0095) 2012; 34 Scheef, Grothe, Koppara, Daamen, Boecker, Biersack, Schild, Wagner, Teipel, Jessen (b0190) 2019; 21 Yan, C., Zang, Y., 2010. DPARSF: a MATLAB toolbox for“ pipeline” data analysis of resting-state fMRI. Front. Syst. Neurosci. 4, 13. Doi: 10.3389/fnsys.2010.00013. Biswal, Zerrin Yetkin, Haughton, Hyde (b0020) 1995; 34 Chiesa, Cavedo, Grothe, Houot, Teipel, Potier, Habert, Lista, Dubois, Hampel (b0040) 2018; 290 Joel, Caffo, van Zijl, Pekar (b0125) 2011; 66 Grothe, Ewers, Krause, Heinsen, Teipel (b0080) 2014; 10 Jack, Petersen, Xu, O'Brien, Smith, Ivnik, Boeve, Waring, Tangalos, Kokmen (b0105) 1999; 52 Janelidze, Zetterberg, Mattsson, Palmqvist, Vanderstichele, Lindberg, van Westen, Stomrud, Minthon, Blennow, Hansson (b0110) 2016; 3 Li, H., Jia, X., Qi, Z., Fan, X., Ma, T., Ni, H., Li, C.R., Li, K., 2017. Altered Functional connectivity of the basal nucleus of meynert in mild cognitive impairment: a resting-state fMRI study. Front. Aging Neurosci. 9, 127. https://doi.org/https://doi.org/10.3389/fnagi.2017.00127. ZHANG, WANG, XING, LIU, MA, YANG, ZHANG, TENG (b0260) 2009; 197 Schmitz, T.W., Spreng, R.N., Weiner, M.W., Aisen, P., Petersen, R., Jack, C.R., Jagust, W., Trojanowki, J.Q., Toga, A.W., Beckett, L., others, 2016. Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology. Nat. commun. 7, 13249. https://doi.org/https://doi.org/10.1038/ncomms13249. Kilimann, Grothe, Heinsen, Alho, Grinberg, Amaro Jr., dos Santos, da Silva, Mitchell, Frisoni, Bokde, Fellgiebel, Filippi, Hampel, Klöppel, Teipel (b0135) 2014; 40 Teipel, Reuter, Stieltjes, Acosta-Cabronero, Ernemann, Fellgiebel, Filippi, Frisoni, Hentschel, Jessen, Klöppel, Meindl, Pouwels, Hauenstein, Hampel (b0225) 2011; 194 Uluğ, Moore, Bojko, Zimmerman (b0235) 1999; 20 López-Sanz, Bruña, Garcés, Martín-Buro, Walter, Delgado, Montenegro, Higes, Marcos, Maestú (b0150) 2017; 9 Zhou, Dougherty, Hubner, Bai, Cannon, Hutson (b0265) 2008; 4 Henf, Grothe, Brueggen, Teipel, Dyrba (b0090) 2018; 17 Jessen, Spottke, Boecker, Brosseron, Buerger, Catak, Fliessbach, Franke, Fuentes, Heneka, Janowitz, Kilimann, Laske, Menne, Nestor, Peters, Priller, Pross, Ramirez, Schneider, Speck, Spruth, Teipel, Vukovich, Westerteicher, Wiltfang, Wolfsgruber, Wagner, Düzel (b0120) 2018; 10 Grothe, Heinsen, Teipel (b0075) 2012; 71 Schulz, J., Pagano, G., Fernández Bonfante, J.A., Wilson, H., Politis, M., 2018. Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson’s disease. Brain 141, 1501–1516. https://doi.org/https://doi.org/10.1093/brain/awy072. Whitehouse, Price, Clark, Coyle, DeLong (b0245) 1981; 10 Teipel, Kuper-Smith, Bartels, Brosseron, Buchmann, Buerger, Catak, Janowitz, Dechent, Dobisch, Ertl-Wagner, Fließbach, Haynes, Heneka, Kilimann, Laske, Li, Menne, Metzger, Priller, Pross, Ramirez, Scheffler, Schneider, Spottke, Spruth, Wagner, Wiltfang, Wolfsgruber, Düzel, Jessen, Dyrba, Zhou (b0215) 2019; 72 Jessen, Amariglio, van Boxtel, Breteler, Ceccaldi, Chételat, Dubois, Dufouil, Ellis, van der Flier, Glodzik, van Harten, de Leon, McHugh, Mielke, Molinuevo, Mosconi, Osorio, Perrotin, Petersen, Rabin, Rami, Reisberg, Rentz, Sachdev, de la Sayette, Saykin, Scheltens, Shulman, Slavin, Sperling, Stewart, Uspenskaya, Vellas, Visser, Wagner (b0115) 2014; 10 Hafkemeijer, Altmann-Schneider, Oleksik, van de Wiel, Middelkoop, van Buchem, van der Grond, Rombouts (b0085) 2013; 3 Bohnen, Grothe, Ray, Müller, Teipel (b0025) 2018; 7 Whitehouse, Price, Struble, Clark, Coyle, Delon (b0250) 1982; 215 Glover (b0065) 2011; 22 Kilimann (10.1016/j.nicl.2020.102495_b0135) 2014; 40 Glover (10.1016/j.nicl.2020.102495_b0065) 2011; 22 Jack (10.1016/j.nicl.2020.102495_b0100) 2000; 55 McKhann (10.1016/j.nicl.2020.102495_b0160) 2011; 7 Ashburner (10.1016/j.nicl.2020.102495_b0010) 2007; 38 DeKosky (10.1016/j.nicl.2020.102495_b0045) 2002; 51 Biswal (10.1016/j.nicl.2020.102495_b0020) 1995; 34 McGeer (10.1016/j.nicl.2020.102495_b0155) 1984; 34 Grothe (10.1016/j.nicl.2020.102495_b0075) 2012; 71 Bohnen (10.1016/j.nicl.2020.102495_b0025) 2018; 7 Henf (10.1016/j.nicl.2020.102495_b0090) 2018; 17 ZHANG (10.1016/j.nicl.2020.102495_b0260) 2009; 197 10.1016/j.nicl.2020.102495_b0255 Teipel (10.1016/j.nicl.2020.102495_b0230) 2014; 264 Wang (10.1016/j.nicl.2020.102495_b0240) 2006; 31 Muth (10.1016/j.nicl.2020.102495_b0175) 2010; 67 Whitehouse (10.1016/j.nicl.2020.102495_b0250) 1982; 215 Teipel (10.1016/j.nicl.2020.102495_b0220) 2018; 64 Brueggen (10.1016/j.nicl.2020.102495_b0030) 2015; 48 Hong (10.1016/j.nicl.2020.102495_b0095) 2012; 34 Fritz (10.1016/j.nicl.2020.102495_b0055) 2019; 40 Gonzalez-Escamilla (10.1016/j.nicl.2020.102495_b0070) 2017; 147 Grothe (10.1016/j.nicl.2020.102495_b0080) 2014; 10 Jessen (10.1016/j.nicl.2020.102495_b0120) 2018; 10 Teipel (10.1016/j.nicl.2020.102495_b0210) 2020 Hafkemeijer (10.1016/j.nicl.2020.102495_b0085) 2013; 3 Kerbler (10.1016/j.nicl.2020.102495_b0130) 2015; 7 Müller (10.1016/j.nicl.2020.102495_b0170) 2007; 28 Albert (10.1016/j.nicl.2020.102495_b0005) 2011; 7 10.1016/j.nicl.2020.102495_b0140 Teipel (10.1016/j.nicl.2020.102495_b0205) 2014; 35 Ryu (10.1016/j.nicl.2020.102495_b0185) 2017; 29 Brueggen (10.1016/j.nicl.2020.102495_b0035) 2019; 266 Gilmor (10.1016/j.nicl.2020.102495_b0060) 1999; 411 Jessen (10.1016/j.nicl.2020.102495_b0115) 2014; 10 Joel (10.1016/j.nicl.2020.102495_b0125) 2011; 66 Friston (10.1016/j.nicl.2020.102495_b0050) 1996; 35 López-Sanz (10.1016/j.nicl.2020.102495_b0150) 2017; 9 Basser (10.1016/j.nicl.2020.102495_b0015) 1994; 103 Whitehouse (10.1016/j.nicl.2020.102495_b0245) 1981; 10 Pennanen (10.1016/j.nicl.2020.102495_b0180) 2004; 25 Janelidze (10.1016/j.nicl.2020.102495_b0110) 2016; 3 10.1016/j.nicl.2020.102495_b0195 Scheef (10.1016/j.nicl.2020.102495_b0190) 2019; 21 Jack (10.1016/j.nicl.2020.102495_b0105) 1999; 52 Chiesa (10.1016/j.nicl.2020.102495_b0040) 2018; 290 Uluğ (10.1016/j.nicl.2020.102495_b0235) 1999; 20 Zhou (10.1016/j.nicl.2020.102495_b0265) 2008; 4 Mesulam (10.1016/j.nicl.2020.102495_b0165) 1983; 214 Liu (10.1016/j.nicl.2020.102495_b0145) 2015; 129 Teipel (10.1016/j.nicl.2020.102495_b0225) 2011; 194 Teipel (10.1016/j.nicl.2020.102495_b0215) 2019; 72 10.1016/j.nicl.2020.102495_b0200 |
| References_xml | – volume: 7 start-page: 1 year: 2018 end-page: 11 ident: b0025 article-title: Recent Advances in Cholinergic Imaging and Cognitive Decline—Revisiting the Cholinergic Hypothesis of Dementia publication-title: Curr Geri Rep – volume: 7 start-page: 105 year: 2015 end-page: 113 ident: b0130 article-title: Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease publication-title: NeuroImage: Clinical – volume: 20 start-page: 1044 year: 1999 end-page: 1048 ident: b0235 article-title: Clinical use of diffusion-tensor imaging for diseases causing neuronal and axonal damage publication-title: Am. J. Neuroradiol. – volume: 197 start-page: 103 year: 2009 end-page: 108 ident: b0260 article-title: Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease publication-title: Behav. Brain Res. – reference: Yan, C., Zang, Y., 2010. DPARSF: a MATLAB toolbox for“ pipeline” data analysis of resting-state fMRI. Front. Syst. Neurosci. 4, 13. Doi: 10.3389/fnsys.2010.00013. – volume: 9 year: 2017 ident: b0150 article-title: Functional Connectivity Disruption in Subjective Cognitive Decline and Mild Cognitive Impairment: A Common Pattern of Alterations publication-title: Front. Aging Neurosci. – volume: 10 start-page: 844 year: 2014 end-page: 852 ident: b0115 article-title: A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease publication-title: Alzheim. Dementia – reference: Schulz, J., Pagano, G., Fernández Bonfante, J.A., Wilson, H., Politis, M., 2018. Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson’s disease. Brain 141, 1501–1516. https://doi.org/https://doi.org/10.1093/brain/awy072. – volume: 4 start-page: 265 year: 2008 end-page: 270 ident: b0265 article-title: Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment publication-title: Alzheim. Demen. – volume: 64 start-page: 801 year: 2018 end-page: 813 ident: b0220 article-title: Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer’s Disease publication-title: JAD – volume: 40 start-page: 868 year: 2019 end-page: 878 ident: b0055 article-title: The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles publication-title: Hum. Brain Mapp. – volume: 71 start-page: 805 year: 2012 end-page: 813 ident: b0075 article-title: Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease publication-title: Biol. Psychiatry – volume: 34 start-page: 741 year: 1984 ident: b0155 article-title: Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain publication-title: Neurology – volume: 72 start-page: 455 year: 2019 end-page: 465 ident: b0215 article-title: Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer’s Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness publication-title: JAD – volume: 10 start-page: 122 year: 1981 end-page: 126 ident: b0245 article-title: Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis publication-title: Ann. Neurol. – volume: 38 start-page: 95 year: 2007 end-page: 113 ident: b0010 article-title: A fast diffeomorphic image registration algorithm publication-title: NeuroImage – volume: 7 start-page: 270 year: 2011 end-page: 279 ident: b0005 article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheim. Demen. – volume: 21 start-page: 101612 year: 2019 ident: b0190 article-title: Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD) publication-title: NeuroImage: Clinical – reference: Schmitz, T.W., Spreng, R.N., Weiner, M.W., Aisen, P., Petersen, R., Jack, C.R., Jagust, W., Trojanowki, J.Q., Toga, A.W., Beckett, L., others, 2016. Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology. Nat. commun. 7, 13249. https://doi.org/https://doi.org/10.1038/ncomms13249. – volume: 52 start-page: 1397 year: 1999 ident: b0105 article-title: Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment publication-title: Neurology – volume: 129 start-page: 527 year: 2015 end-page: 540 ident: b0145 article-title: Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease publication-title: Acta Neuropathol. – volume: 31 start-page: 496 year: 2006 end-page: 504 ident: b0240 article-title: Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI publication-title: NeuroImage – volume: 55 start-page: 484 year: 2000 end-page: 490 ident: b0100 article-title: Rates of hippocampal atrophy correlate with change in clinical status in aging and AD publication-title: Neurology – volume: 3 start-page: 353 year: 2013 end-page: 362 ident: b0085 article-title: Increased Functional Connectivity and Brain Atrophy in Elderly with Subjective Memory Complaints publication-title: Brain Connect. – volume: 40 start-page: 687 year: 2014 end-page: 700 ident: b0135 article-title: Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study publication-title: JAD – volume: 103 start-page: 247 year: 1994 end-page: 254 ident: b0015 article-title: Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo publication-title: J. Magn. Reson., Ser B – volume: 10 year: 2018 ident: b0120 article-title: Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE) publication-title: Alz. Res. Therapy – volume: 266 start-page: 2465 year: 2019 end-page: 2474 ident: b0035 article-title: Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease based on multicenter diffusion tensor imaging publication-title: J. Neurol. – volume: 10 start-page: S344 year: 2014 end-page: S353 ident: b0080 article-title: Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects publication-title: Alzheimer's & Dementia – volume: 28 start-page: 398 year: 2007 end-page: 403 ident: b0170 article-title: Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI publication-title: Neurobiol. Aging – volume: 214 start-page: 170 year: 1983 end-page: 197 ident: b0165 article-title: Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey publication-title: J. Comp. Neurol. – volume: 22 start-page: 133 year: 2011 end-page: 139 ident: b0065 article-title: Overview of Functional Magnetic Resonance Imaging publication-title: Neurosurg. Clin. N. Am. – volume: 35 start-page: 346 year: 1996 end-page: 355 ident: b0050 article-title: Movement-Related effects in fMRI time-series: Movement Artifacts in fMRI publication-title: Magn. Reson. Med. – volume: 34 start-page: 537 year: 1995 end-page: 541 ident: b0020 article-title: Functional connectivity in the motor cortex of resting human brain using echo-planar mri publication-title: Magn. Reson. Med. – volume: 215 start-page: 1237 year: 1982 end-page: 1239 ident: b0250 article-title: Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain publication-title: Science – volume: 48 start-page: 197 year: 2015 end-page: 204 ident: b0030 article-title: Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer’s Disease in Patients with Mild Cognitive Impairment – A Multicenter DTI and Volumetry Study publication-title: JAD – volume: 51 start-page: 145 year: 2002 end-page: 155 ident: b0045 article-title: Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment publication-title: Ann. Neurol. – volume: 7 start-page: 263 year: 2011 end-page: 269 ident: b0160 article-title: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheim. Demen. – volume: 3 start-page: 154 year: 2016 end-page: 165 ident: b0110 article-title: CSF A42/A40 and A42/A38 ratios: better diagnostic markers of Alzheimer disease publication-title: Ann. Clin. Transl. Neurol. – volume: 290 start-page: 167 year: 2018 end-page: 176 ident: b0040 article-title: Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-β Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints publication-title: Radiology – volume: 67 start-page: 588 year: 2010 end-page: 591 ident: b0175 article-title: Mild Cognitive Impairment in the Elderly is Associated with Volume Loss of the Cholinergic Basal Forebrain Region publication-title: Biol. Psychiatry – volume: 66 start-page: 644 year: 2011 end-page: 657 ident: b0125 article-title: On the relationship between seed-based and ICA-based measures of functional connectivity: Relationship Between Seed-Based and ICA Connectivity publication-title: Magn. Reson. Med. – volume: 34 start-page: 1215 year: 2012 end-page: 1221 ident: b0095 article-title: Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and Alzheimer’s disease: a diffusion tensor imaging study publication-title: Neurol Sci – volume: 411 start-page: 693 year: 1999 end-page: 704 ident: b0060 article-title: Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer’s disease publication-title: J. Comp. Neurol. – volume: 17 start-page: 579 year: 2018 end-page: 586 ident: b0090 article-title: Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction publication-title: NeuroImage: Clinical – volume: 194 start-page: 363 year: 2011 end-page: 371 ident: b0225 article-title: Multicenter stability of diffusion tensor imaging measures: A European clinical and physical phantom study publication-title: Psychiat. Res. Neuroimag. – volume: 29 start-page: 785 year: 2017 end-page: 792 ident: b0185 article-title: Hippocampal and entorhinal structures in subjective memory impairment: a combined MRI volumetric and DTI study publication-title: Int. Psychogeriatr. – year: 2020 ident: b0210 article-title: Alzheimer’s Disease Neuroimaging Initiative, others, Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease publication-title: Neurology – volume: 264 start-page: 467 year: 2014 end-page: 483 ident: b0230 article-title: Diffusion tensor imaging in Alzheimer’s disease and affective disorders publication-title: Eur. Arch. Psychiatry Clin. Neurosci. – volume: 35 start-page: 482 year: 2014 end-page: 491 ident: b0205 article-title: Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease publication-title: Neurobiol. Aging – volume: 25 start-page: 303 year: 2004 end-page: 310 ident: b0180 article-title: Hippocampus and entorhinal cortex in mild cognitive impairment and early AD publication-title: Neurobiol. Aging – volume: 147 start-page: 669 year: 2017 end-page: 677 ident: b0070 article-title: PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET – Application to amyloid imaging with AV45-PET publication-title: NeuroImage – reference: Li, H., Jia, X., Qi, Z., Fan, X., Ma, T., Ni, H., Li, C.R., Li, K., 2017. Altered Functional connectivity of the basal nucleus of meynert in mild cognitive impairment: a resting-state fMRI study. Front. Aging Neurosci. 9, 127. https://doi.org/https://doi.org/10.3389/fnagi.2017.00127. – volume: 9 year: 2017 ident: 10.1016/j.nicl.2020.102495_b0150 article-title: Functional Connectivity Disruption in Subjective Cognitive Decline and Mild Cognitive Impairment: A Common Pattern of Alterations publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2017.00109 – volume: 129 start-page: 527 issue: 4 year: 2015 ident: 10.1016/j.nicl.2020.102495_b0145 article-title: Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-015-1392-5 – volume: 34 start-page: 1215 issue: 7 year: 2012 ident: 10.1016/j.nicl.2020.102495_b0095 article-title: Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and Alzheimer’s disease: a diffusion tensor imaging study publication-title: Neurol Sci doi: 10.1007/s10072-012-1225-4 – volume: 7 start-page: 1 issue: 1 year: 2018 ident: 10.1016/j.nicl.2020.102495_b0025 article-title: Recent Advances in Cholinergic Imaging and Cognitive Decline—Revisiting the Cholinergic Hypothesis of Dementia publication-title: Curr Geri Rep doi: 10.1007/s13670-018-0234-4 – volume: 10 start-page: 844 issue: 6 year: 2014 ident: 10.1016/j.nicl.2020.102495_b0115 article-title: A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease publication-title: Alzheim. Dementia doi: 10.1016/j.jalz.2014.01.001 – volume: 214 start-page: 170 issue: 2 year: 1983 ident: 10.1016/j.nicl.2020.102495_b0165 article-title: Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey publication-title: J. Comp. Neurol. doi: 10.1002/cne.902140206 – volume: 34 start-page: 741 issue: 6 year: 1984 ident: 10.1016/j.nicl.2020.102495_b0155 article-title: Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain publication-title: Neurology doi: 10.1212/WNL.34.6.741 – volume: 55 start-page: 484 issue: 4 year: 2000 ident: 10.1016/j.nicl.2020.102495_b0100 article-title: Rates of hippocampal atrophy correlate with change in clinical status in aging and AD publication-title: Neurology doi: 10.1212/WNL.55.4.484 – ident: 10.1016/j.nicl.2020.102495_b0200 doi: 10.1093/brain/awy072 – volume: 51 start-page: 145 issue: 2 year: 2002 ident: 10.1016/j.nicl.2020.102495_b0045 article-title: Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment publication-title: Ann. Neurol. doi: 10.1002/ana.10069 – volume: 40 start-page: 687 issue: 3 year: 2014 ident: 10.1016/j.nicl.2020.102495_b0135 article-title: Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study publication-title: JAD doi: 10.3233/JAD-132345 – ident: 10.1016/j.nicl.2020.102495_b0255 doi: 10.3389/fnsys.2010.00013 – volume: 35 start-page: 346 issue: 3 year: 1996 ident: 10.1016/j.nicl.2020.102495_b0050 article-title: Movement-Related effects in fMRI time-series: Movement Artifacts in fMRI publication-title: Magn. Reson. Med. doi: 10.1002/mrm.1910350312 – volume: 31 start-page: 496 issue: 2 year: 2006 ident: 10.1016/j.nicl.2020.102495_b0240 article-title: Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI publication-title: NeuroImage doi: 10.1016/j.neuroimage.2005.12.033 – volume: 20 start-page: 1044 year: 1999 ident: 10.1016/j.nicl.2020.102495_b0235 article-title: Clinical use of diffusion-tensor imaging for diseases causing neuronal and axonal damage publication-title: Am. J. Neuroradiol. – volume: 35 start-page: 482 issue: 3 year: 2014 ident: 10.1016/j.nicl.2020.102495_b0205 article-title: Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.09.029 – volume: 66 start-page: 644 issue: 3 year: 2011 ident: 10.1016/j.nicl.2020.102495_b0125 article-title: On the relationship between seed-based and ICA-based measures of functional connectivity: Relationship Between Seed-Based and ICA Connectivity publication-title: Magn. Reson. Med. doi: 10.1002/mrm.22818 – ident: 10.1016/j.nicl.2020.102495_b0195 doi: 10.1038/ncomms13249 – volume: 67 start-page: 588 issue: 6 year: 2010 ident: 10.1016/j.nicl.2020.102495_b0175 article-title: Mild Cognitive Impairment in the Elderly is Associated with Volume Loss of the Cholinergic Basal Forebrain Region publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.02.026 – volume: 25 start-page: 303 issue: 3 year: 2004 ident: 10.1016/j.nicl.2020.102495_b0180 article-title: Hippocampus and entorhinal cortex in mild cognitive impairment and early AD publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(03)00084-8 – volume: 3 start-page: 353 issue: 4 year: 2013 ident: 10.1016/j.nicl.2020.102495_b0085 article-title: Increased Functional Connectivity and Brain Atrophy in Elderly with Subjective Memory Complaints publication-title: Brain Connect. doi: 10.1089/brain.2013.0144 – volume: 197 start-page: 103 issue: 1 year: 2009 ident: 10.1016/j.nicl.2020.102495_b0260 article-title: Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2008.08.012 – volume: 147 start-page: 669 year: 2017 ident: 10.1016/j.nicl.2020.102495_b0070 article-title: PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET – Application to amyloid imaging with AV45-PET publication-title: NeuroImage doi: 10.1016/j.neuroimage.2016.12.077 – volume: 194 start-page: 363 issue: 3 year: 2011 ident: 10.1016/j.nicl.2020.102495_b0225 article-title: Multicenter stability of diffusion tensor imaging measures: A European clinical and physical phantom study publication-title: Psychiat. Res. Neuroimag. doi: 10.1016/j.pscychresns.2011.05.012 – volume: 71 start-page: 805 issue: 9 year: 2012 ident: 10.1016/j.nicl.2020.102495_b0075 article-title: Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.06.019 – volume: 29 start-page: 785 issue: 5 year: 2017 ident: 10.1016/j.nicl.2020.102495_b0185 article-title: Hippocampal and entorhinal structures in subjective memory impairment: a combined MRI volumetric and DTI study publication-title: Int. Psychogeriatr. doi: 10.1017/S1041610216002349 – volume: 3 start-page: 154 year: 2016 ident: 10.1016/j.nicl.2020.102495_b0110 article-title: CSF A42/A40 and A42/A38 ratios: better diagnostic markers of Alzheimer disease publication-title: Ann. Clin. Transl. Neurol. doi: 10.1002/acn3.274 – volume: 10 issue: 1 year: 2018 ident: 10.1016/j.nicl.2020.102495_b0120 article-title: Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE) publication-title: Alz. Res. Therapy doi: 10.1186/s13195-017-0314-2 – volume: 10 start-page: 122 issue: 2 year: 1981 ident: 10.1016/j.nicl.2020.102495_b0245 article-title: Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis publication-title: Ann. Neurol. doi: 10.1002/ana.410100203 – volume: 34 start-page: 537 issue: 4 year: 1995 ident: 10.1016/j.nicl.2020.102495_b0020 article-title: Functional connectivity in the motor cortex of resting human brain using echo-planar mri publication-title: Magn. Reson. Med. doi: 10.1002/mrm.1910340409 – volume: 28 start-page: 398 issue: 3 year: 2007 ident: 10.1016/j.nicl.2020.102495_b0170 article-title: Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2006.01.009 – volume: 7 start-page: 105 year: 2015 ident: 10.1016/j.nicl.2020.102495_b0130 article-title: Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease publication-title: NeuroImage: Clinical doi: 10.1016/j.nicl.2014.11.015 – volume: 411 start-page: 693 year: 1999 ident: 10.1016/j.nicl.2020.102495_b0060 article-title: Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer’s disease publication-title: J. Comp. Neurol. doi: 10.1002/(SICI)1096-9861(19990906)411:4<693::AID-CNE13>3.0.CO;2-D – volume: 72 start-page: 455 issue: 2 year: 2019 ident: 10.1016/j.nicl.2020.102495_b0215 article-title: Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer’s Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness publication-title: JAD doi: 10.3233/JAD-190446 – volume: 290 start-page: 167 issue: 1 year: 2018 ident: 10.1016/j.nicl.2020.102495_b0040 article-title: Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-β Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints publication-title: Radiology doi: 10.1148/radiol.2018180268 – volume: 7 start-page: 270 issue: 3 year: 2011 ident: 10.1016/j.nicl.2020.102495_b0005 article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheim. Demen. doi: 10.1016/j.jalz.2011.03.008 – volume: 215 start-page: 1237 issue: 4537 year: 1982 ident: 10.1016/j.nicl.2020.102495_b0250 article-title: Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain publication-title: Science doi: 10.1126/science.7058341 – volume: 264 start-page: 467 issue: 6 year: 2014 ident: 10.1016/j.nicl.2020.102495_b0230 article-title: Diffusion tensor imaging in Alzheimer’s disease and affective disorders publication-title: Eur. Arch. Psychiatry Clin. Neurosci. doi: 10.1007/s00406-014-0496-6 – volume: 4 start-page: 265 issue: 4 year: 2008 ident: 10.1016/j.nicl.2020.102495_b0265 article-title: Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment publication-title: Alzheim. Demen. doi: 10.1016/j.jalz.2008.04.006 – year: 2020 ident: 10.1016/j.nicl.2020.102495_b0210 article-title: Alzheimer’s Disease Neuroimaging Initiative, others, Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease publication-title: Neurology doi: 10.1212/WNL.0000000000010192 – volume: 21 start-page: 101612 year: 2019 ident: 10.1016/j.nicl.2020.102495_b0190 article-title: Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD) publication-title: NeuroImage: Clinical doi: 10.1016/j.nicl.2018.101612 – volume: 7 start-page: 263 issue: 3 year: 2011 ident: 10.1016/j.nicl.2020.102495_b0160 article-title: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheim. Demen. doi: 10.1016/j.jalz.2011.03.005 – volume: 52 start-page: 1397 issue: 7 year: 1999 ident: 10.1016/j.nicl.2020.102495_b0105 article-title: Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment publication-title: Neurology doi: 10.1212/WNL.52.7.1397 – volume: 64 start-page: 801 issue: 3 year: 2018 ident: 10.1016/j.nicl.2020.102495_b0220 article-title: Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer’s Disease publication-title: JAD doi: 10.3233/JAD-180106 – volume: 48 start-page: 197 issue: 1 year: 2015 ident: 10.1016/j.nicl.2020.102495_b0030 article-title: Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer’s Disease in Patients with Mild Cognitive Impairment – A Multicenter DTI and Volumetry Study publication-title: JAD doi: 10.3233/JAD-150063 – volume: 40 start-page: 868 issue: 3 year: 2019 ident: 10.1016/j.nicl.2020.102495_b0055 article-title: The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.24417 – volume: 22 start-page: 133 issue: 2 year: 2011 ident: 10.1016/j.nicl.2020.102495_b0065 article-title: Overview of Functional Magnetic Resonance Imaging publication-title: Neurosurg. Clin. N. Am. doi: 10.1016/j.nec.2010.11.001 – volume: 10 start-page: S344 year: 2014 ident: 10.1016/j.nicl.2020.102495_b0080 article-title: Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects publication-title: Alzheimer's & Dementia doi: 10.1016/j.jalz.2013.09.011 – volume: 38 start-page: 95 issue: 1 year: 2007 ident: 10.1016/j.nicl.2020.102495_b0010 article-title: A fast diffeomorphic image registration algorithm publication-title: NeuroImage doi: 10.1016/j.neuroimage.2007.07.007 – ident: 10.1016/j.nicl.2020.102495_b0140 doi: 10.3389/fnagi.2017.00127 – volume: 266 start-page: 2465 issue: 10 year: 2019 ident: 10.1016/j.nicl.2020.102495_b0035 article-title: Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease based on multicenter diffusion tensor imaging publication-title: J. Neurol. doi: 10.1007/s00415-019-09429-3 – volume: 17 start-page: 579 year: 2018 ident: 10.1016/j.nicl.2020.102495_b0090 article-title: Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction publication-title: NeuroImage: Clinical doi: 10.1016/j.nicl.2017.10.005 – volume: 103 start-page: 247 issue: 3 year: 1994 ident: 10.1016/j.nicl.2020.102495_b0015 article-title: Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo publication-title: J. Magn. Reson., Ser B doi: 10.1006/jmrb.1994.1037 |
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| Snippet | •Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum.•Robust changes in cBF volume and diffusivity in MCI and AD dementia.•Only... Highlights•Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum. •Robust changes in cBF volume and diffusivity in MCI and AD... Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the... • Multimodal MRI analysis of cholinergic basal forebrain (cBF) changes in AD spectrum. • Robust changes in cBF volume and diffusivity in MCI and AD dementia. •... Background: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for... |
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| SubjectTerms | Alzheimer Disease Alzheimer Disease - diagnostic imaging Alzheimer’s Disease Basal Forebrain Basal Forebrain - diagnostic imaging Cholinergic Basal Forebrain Cognitive Dysfunction Cognitive Dysfunction - diagnostic imaging Cohort Studies Computer applications to medicine. Medical informatics ddc:610 diagnostic imaging [Alzheimer Disease] diagnostic imaging [Basal Forebrain] diagnostic imaging [Cognitive Dysfunction] Functional Connectivity Humans Magnetic Resonance Imaging Mean Diffusivity Neurology. Diseases of the nervous system R858-859.7 Radiology RC346-429 Regular Regular Article Resting-state fMRI Subjective Cognitive Decline |
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| Title | Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum |
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