3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(Piperidin-1-yl)propyl]indoles:  Agonists for the h5-HT 1D Receptor with High Selectivity over the h5-HT 1B Subtype

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Published inJournal of medicinal chemistry Vol. 40; no. 22; pp. 3497 - 3500
Main Authors Castro, José L., Street, Leslie J., Guiblin, Alexander R., Jelley, Richard A., Russell, Michael G. N., Sternfeld, Francine, Beer, Margaret S., Stanton, Josephine A., Matassa, Victor G.
Format Journal Article
LanguageEnglish
Published 01.10.1997
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Author Beer, Margaret S.
Matassa, Victor G.
Castro, José L.
Sternfeld, Francine
Guiblin, Alexander R.
Stanton, Josephine A.
Street, Leslie J.
Russell, Michael G. N.
Jelley, Richard A.
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Cites_doi 10.1046/j.1468-2982.1996.1602113.x
10.1073/pnas.91.9.3666
10.1161/01.CIR.90.3.1141
10.1111/j.1365-2125.1995.tb05780.x
10.1016/0014-5793(95)00828-W
10.2165/00023210-199503020-00002
10.1016/0960-894X(96)00324-1
10.1016/0165-6147(93)90084-W
10.1073/pnas.89.8.3630
10.1111/j.1365-2125.1996.tb00005.x
10.1021/jm00163a012
10.1016/S0223-5234(97)84362-0
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References Sternfeld F. (jm9704558b00017/jm9704558b00017_1) 1996; 6
Lazareno S. (jm9704558b00023/jm9704558b00023_1) 1993; 109
Kaumann A. J. (jm9704558b00011/jm9704558b00011_2) 1994; 90
Ullmer C. (jm9704558b00008/jm9704558b00008_1) 1995; 370
Plosker G. L. (jm9704558b00002/jm9704558b00002_1) 1994; 47
Cutler N. R. (jm9704558b00003/jm9704558b00003_2) 1996; 16
Ottervanger J. P. (jm9704558b00012/jm9704558b00012_1) 1995; 3
Humphrey P. P. A. (jm9704558b00004/jm9704558b00004_1) 1994; 14
Ferro A. (jm9704558b00013/jm9704558b00013_1) 1995; 40
Bax W. A. (jm9704558b00011/jm9704558b00011_1) 1993; 239
Castro J. L. (jm9704558b00018/jm9704558b00018_1) 1996
Ferrari M. D (jm9704558b00001/jm9704558b00001_1) 1993; 43
Hamel E. (jm9704558b00008/jm9704558b00008_2) 1993; 44
Street L. J. (jm9704558b00003/jm9704558b00003_1) 1995; 38
Longmore J. (jm9704558b00013/jm9704558b00013_2) 1996; 42
Bremner D. H. (jm9704558b00015/jm9704558b00015_1) 1997; 32
Mesylate (jm9704558b00020/jm9704558b00020_1) 1994
Weinshank R. L. (jm9704558b00007/jm9704558b00007_1) 1992; 89
Ferrari M. D. (jm9704558b00005/jm9704558b00005_1) 1993; 14
Veldman S. A. (jm9704558b00021/jm9704558b00021_1) 1992; 42
Bouchelet I. (jm9704558b00009/jm9704558b00009_1) 1996; 50
Nielsen L. (jm9704558b00016/jm9704558b00016_1) 1990; 33
Moskowitz M. A (jm9704558b00006/jm9704558b00006_1) 1993; 43
Rebeck G. W. (jm9704558b00010/jm9704558b00010_1) 1994; 91
References_xml – volume: 16
  start-page: 116
  year: 1996
  ident: jm9704558b00003/jm9704558b00003_2
  publication-title: Cephalalgia
  doi: 10.1046/j.1468-2982.1996.1602113.x
  contributor:
    fullname: Cutler N. R.
– volume: 91
  start-page: 3669
  year: 1994
  ident: jm9704558b00010/jm9704558b00010_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.91.9.3666
  contributor:
    fullname: Rebeck G. W.
– volume: 90
  start-page: 1153
  year: 1994
  ident: jm9704558b00011/jm9704558b00011_2
  publication-title: Circulation
  doi: 10.1161/01.CIR.90.3.1141
  contributor:
    fullname: Kaumann A. J.
– volume: 40
  start-page: 251
  issue: 3
  year: 1995
  ident: jm9704558b00013/jm9704558b00013_1
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/j.1365-2125.1995.tb05780.x
  contributor:
    fullname: Ferro A.
– volume-title: Synthesis of the 5-HT1D Receptor Agonist MK-462 via a Pd-Catalyzed Coupling Reaction. Tetrahedron Lett
  year: 1994
  ident: jm9704558b00020/jm9704558b00020_1
  contributor:
    fullname: Mesylate
– volume-title: Azetidine, Pyrrolidine and Piperidine Derivatives. World Patent Appl. WO 96/04274
  year: 1996
  ident: jm9704558b00018/jm9704558b00018_1
  contributor:
    fullname: Castro J. L.
– volume: 42
  start-page: 444
  year: 1992
  ident: jm9704558b00021/jm9704558b00021_1
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Veldman S. A.
– volume: 370
  start-page: 221
  year: 1995
  ident: jm9704558b00008/jm9704558b00008_1
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(95)00828-W
  contributor:
    fullname: Ullmer C.
– volume: 109
  start-page: 1127
  year: 1993
  ident: jm9704558b00023/jm9704558b00023_1
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Lazareno S.
– volume: 44
  start-page: 246
  year: 1993
  ident: jm9704558b00008/jm9704558b00008_2
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Hamel E.
– volume: 3
  start-page: 98
  issue: 2
  year: 1995
  ident: jm9704558b00012/jm9704558b00012_1
  publication-title: CNS Drugs
  doi: 10.2165/00023210-199503020-00002
  contributor:
    fullname: Ottervanger J. P.
– volume: 6
  start-page: 1830
  year: 1996
  ident: jm9704558b00017/jm9704558b00017_1
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/0960-894X(96)00324-1
  contributor:
    fullname: Sternfeld F.
– volume: 50
  start-page: 223
  year: 1996
  ident: jm9704558b00009/jm9704558b00009_1
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Bouchelet I.
– volume: 14
  start-page: 133
  year: 1993
  ident: jm9704558b00005/jm9704558b00005_1
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/0165-6147(93)90084-W
  contributor:
    fullname: Ferrari M. D.
– volume: 89
  start-page: 3634
  year: 1992
  ident: jm9704558b00007/jm9704558b00007_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.89.8.3630
  contributor:
    fullname: Weinshank R. L.
– volume: 239
  start-page: 210
  year: 1993
  ident: jm9704558b00011/jm9704558b00011_1
  publication-title: Eur. J. Pharmacol.
  contributor:
    fullname: Bax W. A.
– volume: 42
  start-page: 441
  year: 1996
  ident: jm9704558b00013/jm9704558b00013_2
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/j.1365-2125.1996.tb00005.x
  contributor:
    fullname: Longmore J.
– volume: 43
  start-page: S47
  year: 1993
  ident: jm9704558b00001/jm9704558b00001_1
  publication-title: Neurology
  contributor:
    fullname: Ferrari M. D
– volume: 33
  start-page: 77
  year: 1990
  ident: jm9704558b00016/jm9704558b00016_1
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00163a012
  contributor:
    fullname: Nielsen L.
– volume: 47
  start-page: 651
  year: 1994
  ident: jm9704558b00002/jm9704558b00002_1
  publication-title: Drugs
  contributor:
    fullname: Plosker G. L.
– volume: 14
  start-page: 410
  year: 1994
  ident: jm9704558b00004/jm9704558b00004_1
  publication-title: Cephalalgia
  contributor:
    fullname: Humphrey P. P. A.
– volume: 32
  start-page: 69
  year: 1997
  ident: jm9704558b00015/jm9704558b00015_1
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/S0223-5234(97)84362-0
  contributor:
    fullname: Bremner D. H.
– volume: 38
  start-page: 1810
  year: 1995
  ident: jm9704558b00003/jm9704558b00003_1
  publication-title: Receptors. J. Med. Chem.
  contributor:
    fullname: Street L. J.
– volume: 43
  start-page: S20
  year: 1993
  ident: jm9704558b00006/jm9704558b00006_1
  publication-title: Neurology
  contributor:
    fullname: Moskowitz M. A
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Title 3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(Piperidin-1-yl)propyl]indoles:  Agonists for the h5-HT 1D Receptor with High Selectivity over the h5-HT 1B Subtype
Volume 40
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