Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase

• Published in: Nature biotechnology Vol. 34; no. 10; pp. 1066 - 1071
• Main Authors: Olofsson, Peder S, Steinberg, Benjamin E, Sobbi, Roozbeh, Cox, Maureen A, Ahmed, Mohamed N, Oswald, Michaela, Szekeres, Ferenc, Hanes, William M, Introini, Andrea, Liu, Shu Fang, Holodick, Nichol E, Rothstein, Thomas L, Lövdahl, Cecilia, Chavan, Sangeeta S, Yang, Huan, Pavlov, Valentin A, Broliden, Kristina, Andersson, Ulf, Diamond, Betty, Miller, Edmund J, Arner, Anders, Gregersen, Peter K, Backx, Peter H, Mak, Tak W, Tracey, Kevin J
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2016; Nature Publishing Group
• Subjects: 38; 631/250/1619/554/1898; 631/378/2607; 631/443/592/75/243; 631/80/304; 64/110; 692/308/1426; 96/106; Age and Ageing; Agriculture; Animals; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Blood pressure; Blood Pressure - physiology; CD4-positive T cells; CD4-Positive T-Lymphocytes - physiology; Cells, Cultured; Choline O-Acetyltransferase - metabolism; Control; Enzymes; Experimental models of disease; Feedback, Physiological - physiology; Female; Health aspects; Hemostasis - physiology; Homeostasis; Hypertension; Immune system; letter; Life Sciences; Lymphocytes; Male; Mechanisms of disease; Mice; Mice, Inbred C57BL; Neuro–vascular interactions; Nitrates; Nitric oxide; Nitrites; Transferases; Äldre och åldrande

A CD4 T-cell population expressing choline acetyltransferase is shown to contribute to blood pressure regulation. Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously...