Effects of Anticholinergic Drugs Used for the Therapy of Overactive Bladder on P-Glycoprotein Activity

• Published in: Biological & pharmaceutical bulletin Vol. 42; no. 12; pp. 1996 - 2001
• Main Authors: Wakuda, Hirokazu, Okura, Takashi, Maruyama-Fumoto, Kana, Kagota, Satomi, Ito, Yoshihiko, Miyauchi-Wakuda, Shino, Otani, Naoyuki, Uemura, Naoto, Yamada, Shizuo, Shinozuka, Kazumasa
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.12.2019; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Adenosine triphosphatase; Adenosine Triphosphatases - metabolism; anticholinergic drug; Anticholinergics; ATP Binding Cassette Transporter, Subfamily B - metabolism; Caco-2 Cells; Cell membranes; Cholinergic Antagonists - pharmacology; Cholinergic Antagonists - therapeutic use; Confocal microscopy; Cyclosporins; Drugs; Glycoproteins; Humans; Metabolites; overactive bladder; P-Glycoprotein; Protein transport; Rhodamine; Urinary Bladder, Overactive - drug therapy; P-glycoprotein; anticholinergic drug; overactive bladder

We evaluated the effects of anticholinergic drugs principally used for the therapy of overactive bladder (OAB) on the activity of P-glycoprotein, an efflux transport protein, in Caco-2 cells. The time-dependent changes in the fluorescence of residual rhodamine 123, a P-glycoprotein activity marker,...