Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination

• Published in: Vaccine Vol. 40; no. 19; pp. 2652 - 2655
• Main Authors: Kato, Hideaki, Miyakawa, Kei, Ohtake, Norihisa, Yamaoka, Yutaro, Yajima, Satoshi, Yamazaki, Etsuko, Shimada, Tomoko, Goto, Atsushi, Nakajima, Hideaki, Ryo, Akihide
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 26.04.2022; Elsevier Limited; The Author(s). Published by Elsevier Ltd
• Subjects: 50% neutralization titer; Adult; Age; Alcohol; alcohol drinking; Allergy and Immunology; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; BNT162 Vaccine; Body mass index; Cell-mediated immunity; confidence interval; Confidence intervals; Coronavirus disease-2019; Coronaviruses; COVID-19 - prevention & control; COVID-19 vaccines; Enzyme-linked immunosorbent assay; Enzymes; gender; Humans; Humoral immunity; IgG antibody; Immune response (humoral); Immunity; Immunity, Cellular; Immunity, Humoral; Immunoassay; Immunoglobulin G; Infections; Interferon; Interferon-γ releasing ELISpot assay; Proteins; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Short Communication; Software; Spike Glycoprotein, Coronavirus; Spike protein; Vaccination; Vaccines; Variant of concern; γ-Interferon; United States > US; Japan; Coronavirus disease-2019; Cell-mediated immunity; Variant of concern; Vaccination; Interferon-γ releasing ELISpot assay; 50% neutralization titer

•Both IgG against spike protein (SP IgG) and 50% neutralizing antibody markedly decreased at 6-month post-vaccination.•SP IgG titer had a negative correlation with age and alcohol consumption, but cellular immunity did not correlate with these factors.•SP IgG titer against the Delta strain was 60% o...