Simultaneous dual‐nuclei imaging for motion corrected detection and quantification of 19 F imaging agents
Abstract Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Because non‐proton MRI applications lack morphological information, accompanying proton images are needed to elucidate the spatial ti...
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| Published in | Magnetic resonance in medicine Vol. 66; no. 4; pp. 1116 - 1122 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.10.2011
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| Online Access | Get full text |
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| Abstract | Abstract
Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Because non‐proton MRI applications lack morphological information, accompanying proton images are needed to elucidate the spatial tissue context. Furthermore, low concentrations typical of targeted molecular imaging agents require long examinations for signal averaging during which physiological motion may lead to blurring, underestimation in signal quantification, and erroneous localization of the agent distribution. Novel methods for truly simultaneous acquisition of dual‐nuclei MR data are presented that offer efficient and precise anatomical localization of fluorine signals using accurate motion correction based on contemporaneous proton signals. The feasibility of simultaneous dual‐nuclei MRI motion correction and corresponding dual‐resolution reconstruction, providing nuclei‐specific spatial resolution to retrospectively optimize the balance between signal‐to‐noise ratio and resolution, is shown on a clinical 3 T MR system. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc. |
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| AbstractList | Abstract
Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Because non‐proton MRI applications lack morphological information, accompanying proton images are needed to elucidate the spatial tissue context. Furthermore, low concentrations typical of targeted molecular imaging agents require long examinations for signal averaging during which physiological motion may lead to blurring, underestimation in signal quantification, and erroneous localization of the agent distribution. Novel methods for truly simultaneous acquisition of dual‐nuclei MR data are presented that offer efficient and precise anatomical localization of fluorine signals using accurate motion correction based on contemporaneous proton signals. The feasibility of simultaneous dual‐nuclei MRI motion correction and corresponding dual‐resolution reconstruction, providing nuclei‐specific spatial resolution to retrospectively optimize the balance between signal‐to‐noise ratio and resolution, is shown on a clinical 3 T MR system. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc. |
| Author | Grässlin, Ingmar Rahmer, Jürgen Mazurkewitz, Peter C. Wickline, Samuel A. Lanza, Gregory M. Schaeffter, Tobias Caruthers, Shelton D. Keupp, Jochen |
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| References | e_1_2_7_5_2 e_1_2_7_4_2 e_1_2_7_2_2 e_1_2_7_9_2 e_1_2_7_8_2 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 e_1_2_7_16_2 e_1_2_7_15_2 Wickline SA (e_1_2_7_3_2) 2010 e_1_2_7_13_2 e_1_2_7_12_2 e_1_2_7_11_2 e_1_2_7_10_2 e_1_2_7_26_2 Keupp J (e_1_2_7_17_2) 2006; 14 Rahmer J (e_1_2_7_21_2) 2009; 17 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_23_2 e_1_2_7_22_2 e_1_2_7_20_2 Keupp J (e_1_2_7_14_2) 2009; 17 |
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Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or... |
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