Reduced Pulsatility Induces Periarteritis in Kidney: Role of the Local Renin–Angiotensin System

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 136; no. 1; pp. 150 - 158
• Main Authors: Ootaki, Chiyo, Yamashita, Michifumi, Ootaki, Yoshio, Kamohara, Keiji, Weber, Stephan, Klatte, Ryan S., Smith, William A., Massiello, Alex L., Emancipator, Steven N., Golding, Leonard A.R., Fukamachi, Kiyotaka
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.07.2008; AATS/WTSA; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angiotensin II - biosynthesis; Animals; Arteritis - pathology; Arteritis - physiopathology; Biological and medical sciences; Cardiology. Vascular system; Cardiothoracic Surgery; Cattle; Hemodynamics; Immunohistochemistry; Kidney - blood supply; Kidney - metabolism; Male; Medical sciences; Nephritis - pathology; Nephritis - physiopathology; Peptidyl-Dipeptidase A - metabolism; Pneumology; Pulsatile Flow; Receptors, Angiotensin - metabolism; Renal Artery - pathology; Renal Artery - physiopathology; Renin-Angiotensin System; pa; RVAD; eNOS; ACE; RAS; 27; 17; AT1R; TAH; Ang II; LVAD; right ventricular assist device; angiotensin II type 1 receptor; renin–angiotensin system; total artificial heart; periarterial areas; angiotensin II; endothelial nitric oxide synthase; left ventricular assist device; angiotensin-converting enzyme; Anesthesia; Renin angiotensin system; Circulatory system; Cardiology; Kidney

The need for pulsatility in the circulation during long-term mechanical support has been a subject of debate. We compared histologic changes in calf renal arteries subjected to various degrees of pulsatile circulation in vivo. We addressed the hypothesis that the local renin–angiotensin system may b...