Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D3

• Published in: Biological & pharmaceutical bulletin Vol. 37; no. 2; pp. 286 - 291
• Main Authors: Okura, Takashi, Higuchi, Kei, Kitamura, Atsushi, Deguchi, Yoshiharu
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.02.2014; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Antiporters - metabolism; apomorphine; Apomorphine - pharmacokinetics; Biological Transport; Blood-Brain Barrier - metabolism; blood–brain barrier; Cations - metabolism; Cell Line; Dopamine Agonists - pharmacokinetics; Endothelial Cells - metabolism; hCMEC/D3 cell; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Organic Cation Transport Proteins - metabolism; proton-coupled organic cation antiporter; Protons; Sodium - metabolism; Stereoisomerism

R(−)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson’s disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(−)-apomorphine and its S-enantiome...