Construction of a Risk Prediction Model of Extended Release Oxycodone Tablet-Induced Nausea and Clarification of Predictive Factors

• Published in: Biological & pharmaceutical bulletin Vol. 44; no. 4; pp. 593 - 598
• Main Authors: Kumai, Masayoshi, Imai, Shungo, Kato, Shintaro, Koyanagi, Ryo, Tsuruga, Kenkichi, Yamada, Takehiro, Takekuma, Yoh, Sugawara, Mitsuru
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.04.2021; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: anti-emetics; Females; Nausea; Opioids; Oxycodone; Prediction models; Regression analysis; retrospective study; risk assessment; Risk factors; oxycodone; risk assessment; anti-emetics; retrospective study; nausea

Nausea is a typical adverse event associated with opioids. In this study, we performed logistic regression analysis with the aim of clarifying the risk factors for nausea induced by extended-release oxycodone (ER-OXY). Furthermore, we constructed a decision tree (DT) model, a typical data mining met...