Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

• Published in: PLoS biology Vol. 19; no. 3; p. e3001158
• Main Authors: V'kovski, Philip, Gultom, Mitra, Kelly, Jenna N, Steiner, Silvio, Russeil, Julie, Mangeat, Bastien, Cora, Elisa, Pezoldt, Joern, Holwerda, Melle, Kratzel, Annika, Laloli, Laura, Wider, Manon, Portmann, Jasmine, Tran, Thao, Ebert, Nadine, Stalder, Hanspeter, Hartmann, Rune, Gardeux, Vincent, Alpern, Daniel, Deplancke, Bart, Thiel, Volker, Dijkman, Ronald
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.03.2021; Public Library of Science (PLoS)
• Subjects: ACE2; Ambient temperature; Amino acids; Analysis; Angiotensin; Angiotensin-converting enzyme 2; Animals; Antibodies; Antiviral Agents - pharmacology; Biology and life sciences; Cell surface; Cells, Cultured; Chlorocebus aethiops; Coronaviruses; COVID-19; DNA replication; Dynamics; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - virology; Epithelium; Gene Expression Profiling - methods; Gene Expression Regulation, Viral - drug effects; Gene Expression Regulation, Viral - genetics; Host-Pathogen Interactions - drug effects; Host-Pathogen Interactions - genetics; Host-virus relationships; Humans; Identification and classification; Immune response; Immune system; Immunofluorescence; Infections; Influenza; Interferons - pharmacology; Medicine and health sciences; Nucleocapsids; Peptidyl-dipeptidase A; Phylogeny; Physiological aspects; Progeny; Receptors; Replication; Respiratory diseases; Respiratory tract; Rhinovirus; SARS-CoV-2 - drug effects; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Serine; Serine proteinase; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - drug effects; Severe acute respiratory syndrome-related coronavirus - genetics; Severe acute respiratory syndrome-related coronavirus - physiology; Species Specificity; Temperature; Temperature dependence; Vero Cells; Viral diseases; Viral infections; Virus Replication - drug effects; Virus Replication - genetics; Viruses; Switzerland

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to-human transmission dynamics, likely due to e...