Multispecies synbiotics alleviate dextran sulfate sodium (DSS)-induced colitis: Effects on clinical scores, intestinal pathology, and plasma biomarkers in male and female mice

• Published in: Clinical nutrition ESPEN Vol. 63; pp. 74 - 83
• Main Authors: Cai, Wenjie, Pierzynowska, Kateryna, Stiernborg, Miranda, Xu, Jingjing, Nilsson, Ida AK, Svensson, Ulla, Melas, Philippe A., Lavebratt, Catharina
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024
• Subjects: anti-inflammatory agents; Bifidobacterium; biomarkers; blood; body weight; Clinical Medicine; clinical nutrition; colitis; colon; dextran sulfate; digestive tract; Experimental colitis; females; Gastroenterologi; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; histology; humans; inflammation; Interleukin-17; Internal Medicine; Klinisk medicin; lactic acid; males; Medical and Health Sciences; Medicin och hälsovetenskap; Mesalazine; placebos; Prebiotic; prebiotics; Probiotic; probiotics; rodents; sodium; sulfates; therapeutics; Probiotic; Experimental colitis; Interleukin-17; Mesalazine; Prebiotic
• ISSN: 2405-4577; 2405-4577
• DOI: 10.1016/j.clnesp.2024.06.011

Inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the gastrointestinal tract and has been linked to an imbalance in gut bacteria. Synbiotics, which combine probiotics and prebiotics, are emerging as potential IBD treatments. To examine the effects of four synbiotic formu...