Delivery of oligonucleotide‐based therapeutics: challenges and opportunities - Hammond, Suzan M; Aartsma‐Rus, Annemieke; Alves, Sandra; Borgos, Sven E; Buijsen, Ronald A M; Collin, Rob W J; Covello, Giuseppina; Denti, Michela A; Desviat, Lourdes R; Echevarría, Lucía; Foged, Camilla; Gaina, Gisela; et al. (EMBO molecular medicine, 2021)
Keywords: Antisense oligonucleotides; Antisense therapy; Aptamers; Chemistry; delivery; Deoxyribonucleic acid; DNA; Drug development; EMBO08; EMBO36; EMBO41; Gene expression; Genes; Homeopathy; Life Sciences; Lipids; Materia medica and therapeutics; Metabolism; MicroRNAs; Molecular weight; Nanoparticles; Nucleic acids; oligonucleotides; Peptides; Polyethylene glycol; preclinical models; Protein expression; Proteins; Regulatory approval; Review; RNA therapeutics; safety; Therapeutics; United States--US; delivery; preclinical models; oligonucleotides; RNA therapeutics; safety