High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report
Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive...
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Published in | Journal of Diabetes Research Vol. 2017; no. 2017; pp. 1 - 7 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2017
Hindawi Hindawi Limited Wiley |
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Abstract | Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. |
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AbstractList | Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM.
Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp.
CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate.
These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. Objective . Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods . Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results . CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions . These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methylglyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. OBJECTIVEAdvanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM.METHODSOur study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp.RESULTSCML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate.CONCLUSIONSThese results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes. |
Audience | Academic |
Author | Taniguchi, Shin-ichi Fujioka, Yohei Sumi, Keisuke Shoji, Kyoko Okura, Tsuyoshi Otsuka, Yuzuru Mihara, Hitomi Matsuzawa, Kazuhiko Izawa, Shoichiro Yamamoto, Kazuhiro Matsumoto, Kazuhisa Nakamura, Risa Nomi, Yuri Ueta, Etsuko Kato, Masahiko |
AuthorAffiliation | 1 Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, Yonago, Tottori, Japan 5 Department of Food and Nutrition, Toita Women's College, Tokyo, Japan 2 School of Health Science, Tottori University Faculty of Medicine, Yonago, Tottori, Japan 3 Department of Regional Medicine, Tottori University Faculty of Medicine, Yonago, Tottori, Japan 4 Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan |
AuthorAffiliation_xml | – name: 3 Department of Regional Medicine, Tottori University Faculty of Medicine, Yonago, Tottori, Japan – name: 5 Department of Food and Nutrition, Toita Women's College, Tokyo, Japan – name: 1 Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, Yonago, Tottori, Japan – name: 2 School of Health Science, Tottori University Faculty of Medicine, Yonago, Tottori, Japan – name: 4 Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan |
Author_xml | – sequence: 1 fullname: Izawa, Shoichiro – sequence: 2 fullname: Mihara, Hitomi – sequence: 3 fullname: Otsuka, Yuzuru – sequence: 4 fullname: Kato, Masahiko – sequence: 5 fullname: Taniguchi, Shin-ichi – sequence: 6 fullname: Yamamoto, Kazuhiro – sequence: 7 fullname: Matsuzawa, Kazuhiko – sequence: 8 fullname: Shoji, Kyoko – sequence: 9 fullname: Matsumoto, Kazuhisa – sequence: 10 fullname: Sumi, Keisuke – sequence: 11 fullname: Fujioka, Yohei – sequence: 12 fullname: Nakamura, Risa – sequence: 13 fullname: Ueta, Etsuko – sequence: 14 fullname: Okura, Tsuyoshi – sequence: 15 fullname: Nomi, Yuri |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28695132$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.2337/diab.37.6.667 10.1186/1475-2840-12-21 10.1016/j.metabol.2004.08.014 10.1210/jc.2006-2384 10.1007/s00125-016-4053-x 10.1002/dmrr.1188 10.1161/01.STR.0000071108.00234.0E 10.2337/dc12-1235 10.1016/S0168-8227(98)00056-4 10.1152/ajpendo.00645.2007 10.1111/j.2040-1124.2010.00091.x 10.1016/S0168-8227(01)00313-8 10.1021/acs.jafc.6b02500 10.2337/diacare.22.9.1462 10.1007/s00726-003-0017-9 10.1210/en.2008-1342 10.1007/s00726-013-1542-9 10.1016/j.chroma.2006.11.066 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S 10.1210/jc.2004-1959 10.1111/dme.12963 10.1152/ajpendo.00151.2015 10.2337/db10-1033 10.2337/diabetes.47.10.1643 10.1007/BF00280883 10.1186/1758-5996-6-113 10.3945/ajcn.115.125427 |
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Snippet | Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin... Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects... Objective . Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin... OBJECTIVEAdvanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory... |
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SubjectTerms | Adult Age Aniline Compounds Blood Glucose - metabolism Blood serum Chromatography Chromatography, Liquid Diabetes Diabetes Mellitus, Type 2 - blood Disease Female Females Glucose Glucose Clamp Technique Glycation End Products, Advanced - blood Glycemic index Homeostasis Humans Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology Male Methods Middle Aged Phenylpropionates Plasma Studies Tandem Mass Spectrometry Type 2 diabetes Young Adult |
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Title | High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report |
URI | https://search.emarefa.net/detail/BIM-1174403 https://dx.doi.org/10.1155/2017/5139750 https://www.ncbi.nlm.nih.gov/pubmed/28695132 https://www.proquest.com/docview/2407645538/abstract/ https://search.proquest.com/docview/1917963342 https://pubmed.ncbi.nlm.nih.gov/PMC5485485 https://doaj.org/article/1cfd3c4fc4bb49a4806cd01f6eb18921 |
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