Gamma-glutamyl carboxylase and its influence on warfarin dose

• Published in: Thrombosis and haemostasis Vol. 104; no. 4; p. 750
• Main Authors: King, Cristi R, Deych, Elena, Milligan, Paul, Eby, Charles, Lenzini, Petra, Grice, Gloria, Porche-Sorbet, Rhonda M, Ridker, Paul M, Gage, Brian F
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2010
• Subjects: Aged; Biomarkers, Pharmacological - metabolism; Carbon-Carbon Ligases - genetics; Carbon-Carbon Ligases - metabolism; Clinical Protocols; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Venous Thrombosis - blood; Venous Thrombosis - diagnosis; Venous Thrombosis - drug therapy; Venous Thrombosis - genetics; Vitamin K - antagonists & inhibitors; Warfarin - pharmacology; Warfarin - therapeutic use

Via generation of vitamin K-dependent proteins, gamma-glutamyl carboxylase (GGCX) plays a critical role in the vitamin K cycle. Single nucleotide polymorphisms (SNPs) in GGCX, therefore, may affect dosing of the vitamin K antagonist, warfarin. In a multi-centered, cross-sectional study of 985 patien...