Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

• Published in: Environmental health perspectives Vol. 123; no. 5; pp. 451 - 457
• Main Authors: Wu, Fen, Jasmine, Farzana, Kibriya, Muhammad G., Liu, Mengling, Cheng, Xin, Parvez, Faruque, Islam, Tariqul, Ahmed, Alauddin, Rakibuz-Zaman, Muhammad, Jiang, Jieying, Roy, Shantanu, Paul-Brutus, Rachelle, Slavkovich, Vesna, Levy, Diane, VanderWeele, Tyler J., Pierce, Brandon L., Graziano, Joseph H., Ahsan, Habibul, Chen, Yu
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.05.2015; NLM-Export
• Subjects: Adjustment; Adult; Arsenic; Arsenic - toxicity; Autopsies; Bangladesh - epidemiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Chemical vapor deposition; Cohort analysis; Contamination; Diagnostic tests; Drinking water; Drinking Water - adverse effects; Environmental aspects; Environmental Exposure; Enzymes; Exposure; Female; Genetic polymorphisms; Genetic variance; Genetics; Genotype; Health; Health aspects; Health risk assessment; Homocysteine; Humans; Inflammation; Intercellular Adhesion Molecule-1 - genetics; Lipids; Longitudinal studies; Male; Medical research; Metabolism; Metabolites; Middle Aged; Oxidative stress; Polymorphism; Polymorphism, Genetic - genetics; Polymorphism, Single Nucleotide - genetics; Population; Prospective Studies; Risk factors; Stroke; Stroke - genetics; Studies; Tumor necrosis factor-TNF; Urine; Vascular Cell Adhesion Molecule-1 - genetics; Bangladesh

Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited. We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs) in 17 genes related t...