Translating the Histone Code

• Published in: Science (American Association for the Advancement of Science) Vol. 293; no. 5532; pp. 1074 - 1080
• Main Authors: Jenuwein, Thomas, Allis, C. David
• Format: Journal Article
• Language: English
• Published: United States American Society for the Advancement of Science 10.08.2001; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Acetylation; Amino Acid Sequence; Animals; Cells; Cells (Biology); Chromatin; Chromatin - chemistry; Chromatin - metabolism; Chromatin - ultrastructure; Coding; Deoxyribonucleic acid; DNA; Double stranded RNA; Epigenetics; Eukaryotes; Eukaryotic cells; Evidence; Gene Expression Regulation; Gene Silencing; Genes; Genetic aspects; Genetic code; Genetics; Genomic Imprinting; Genomics; Heredity; Histones; Histones - chemistry; Histones - genetics; Histones - metabolism; Individualized Instruction; Information Storage; Methylation; Molecular Sequence Data; Nucleosomes; Phosphorylation; Protein Structure, Tertiary; Proteins; Stem cells; Transcription, Genetic; Transcriptional Activation; Viewpoints and Reviews; United States

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate syn...