Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers

• Published in: Journal of Occupational Health Vol. 58; no. 1; pp. 56 - 65
• Main Authors: Sato, Hirotaka, Ito, Yuki, Ueyama, Jun, Kano, Yuya, Arakawa, Tomoya, Gotoh, Masahiro, Kondo, Takaaki, Sugiura, Yuka, Saito, Isao, Shibata, Eiji, Kamijima, Michihiro
• Format: Journal Article
• Language: English
• Published: Australia JAPAN SOCIETY FOR OCCUPATIONAL HEALTH 01.01.2016; Oxford University Press
• Subjects: Acetates; Acetates - metabolism; Adult; Alleles; Aryldialkylphosphatase - genetics; Carboxylic Ester Hydrolases - metabolism; Chlorpyrifos; Chlorpyrifos - analogs & derivatives; Chlorpyrifos - metabolism; Cross-Sectional Studies; Enzymatic activity; Enzyme activity; Enzymes; Female; Fenitrothion - metabolism; Gas chromatography; Gas Chromatography-Mass Spectrometry; Genotype; Humans; Insecticides; Insecticides - urine; Japan; Male; Mass spectrometry; Metabolism; Metabolites; Middle Aged; Occupational Exposure; Occupational health; Organophosphate; Organophosphates; Organophosphates - urine; Paraoxonase 1; Pest Control; Pesticides; Pests; Phenols - metabolism; Polymorphism; Polymorphism, Single Nucleotide; Serums; Urine; INW, Japan

Abstract: Objectives: Paraoxonase 1 (PON1) in serum detoxifies organophosphate (OP) insecticides by hydrolysis. The present cross-sectional study aimed to clarify the relationship between PON1 single nucleotide polymorphisms (SNPs) and enzyme activities or OP metabolite concentrations in urine of wo...