Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products

• Published in: Angewandte Chemie International Edition Vol. 54; no. 26; pp. 7592 - 7596
• Main Authors: Mao, Xu-Ming, Xu, Wei, Li, Dehai, Yin, Wen-Bing, Chooi, Yit-Heng, Li, Yong-Quan, Tang, Yi, Hu, Youcai
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 22.06.2015; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Biological Products - chemical synthesis; Biological Products - chemistry; Biosynthesis; Chemistry; Chemistry, Multidisciplinary; Clusters; endophytic fungi; Epigenetics; Epigenomics; Fungi; Fungi - metabolism; Gene Expression; Genes; Genomes; Genomics; Histones; Inactivation; Inhibitors; Molecular Structure; Natural products; Peptides; Physical Sciences; Science & Technology; natural products; AFLATOXIN; GENE-CLUSTER; DITERPENE CYCLASE; endophytic fungi; POLYKETIDE SYNTHASE; biosynthesis; CALCARISPORIUM STRAIN; DOMAINS; epigenetics; gene expression; ASPERGILLUS

The small‐molecule biosynthetic potential of most filamentous fungi has remained largely unexplored and represents an attractive source for the discovery of new compounds. Genome sequencing of Calcarisporium arbuscula, a mushroom‐endophytic fungus, revealed 68 core genes that are involved in natural...