Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

• Published in: PloS one Vol. 4; no. 2; p. e4606
• Main Authors: Guedj, Fayçal, Sébrié, Catherine, Rivals, Isabelle, Ledru, Aurelie, Paly, Evelyne, Bizot, Jean C, Smith, Desmond, Rubin, Edward, Gillet, Brigitte, Arbones, Mariona, Delabar, Jean M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.02.2009; Public Library of Science (PLoS)
• Subjects: Alterations; analogs & derivatives; Analysis; Angiogenesis; Animals; antagonists & inhibitors; Antioxidants; Antioxidants - pharmacology; Apolipoproteins; Artificial chromosomes; Atherosclerosis; BASIC BIOLOGICAL SCIENCES; Biology; Brain; Brain - growth & development; Brain-derived neurotrophic factor; Catechin; Catechin - analogs & derivatives; Catechin - pharmacology; Cell cycle; Cell density; Consolidation; Defects; Developmental Biology/Neurodevelopment; diet; Dosage; Down syndrome; Down's syndrome; Dyrk Kinases; DYRK1A gene; Edema; Epigallocatechin gallate; Epigallocatechin-3-gallate; Flavonoids; Flavonoids - pharmacology; Gene Dosage; gene overexpression; Genes; Genetic engineering; genetically modified animals; genetics; Genomes; Gestation; Green tea; growth & development; hippocampus; Humans; Intellectual disabilities; Ischemia; Kinases; Learning; Magnetic resonance imaging; Memory; Mice; Mice, Transgenic; Morphogenesis; Morphology; mouse models; Neurological Disorders/Cognitive Neurology and Dementia; Neuronal Plasticity; neuroprotective effect; Neuroscience/Neuronal Signaling Mechanisms; pharmacology; Phenols; Phenols - pharmacology; physiology; Polyphenols; protein kinases; Protein Serine-Threonine Kinases; Protein Serine-Threonine Kinases - antagonists & inhibitors; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - physiology; Protein-Tyrosine Kinases; Protein-Tyrosine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - physiology; Proteins; Rodents; Synaptic plasticity; Tea; Transgenic animals; Transgenic mice; visual object recognition; volume; United States > US; California

Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of...