Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of...
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| Published in | PloS one Vol. 4; no. 2; p. e4606 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
26.02.2009
Public Library of Science (PLoS) |
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| Online Access | Get full text |
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| Abstract | Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) — a member of a natural polyphenols family, found in great amount in green tea leaves — is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. |
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| AbstractList | Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice.Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) — a member of a natural polyphenols family, found in great amount in green tea leaves — is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. |
| Audience | Academic |
| Author | Delabar, Jean M Guedj, Fayçal Gillet, Brigitte Smith, Desmond Rivals, Isabelle Sébrié, Catherine Arbones, Mariona Bizot, Jean C Rubin, Edward Ledru, Aurelie Paly, Evelyne |
| AuthorAffiliation | 3 Equipe de Statistique Appliquée, ESPCI, Paris, France 5 Department of Molecular and Medical Pharmacology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America 4 Key-Obs SA, Parc Technologique de La Source, Orleans, France 2 Laboratoire de RMN Biologique, ICSN-CNRS, Gif sur Yvette, France 7 Center for Genomic Regulation, Universitat Pompeu Fabra (UPF), Barcelona, Spain 1 Functional and Adaptive Biology, Université Paris Diderot-Paris7 and CNRS, Paris, France The Rockefeller University, United States of America 6 Genome Sciences Department, Lawrence Berkeley National Lab (LBNL), Berkeley, California, United States of America |
| AuthorAffiliation_xml | – name: 4 Key-Obs SA, Parc Technologique de La Source, Orleans, France – name: 5 Department of Molecular and Medical Pharmacology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America – name: The Rockefeller University, United States of America – name: 1 Functional and Adaptive Biology, Université Paris Diderot-Paris7 and CNRS, Paris, France – name: 7 Center for Genomic Regulation, Universitat Pompeu Fabra (UPF), Barcelona, Spain – name: 2 Laboratoire de RMN Biologique, ICSN-CNRS, Gif sur Yvette, France – name: 3 Equipe de Statistique Appliquée, ESPCI, Paris, France – name: 6 Genome Sciences Department, Lawrence Berkeley National Lab (LBNL), Berkeley, California, United States of America |
| Author_xml | – sequence: 1 fullname: Guedj, Fayçal – sequence: 2 fullname: Sébrié, Catherine – sequence: 3 fullname: Rivals, Isabelle – sequence: 4 fullname: Ledru, Aurelie – sequence: 5 fullname: Paly, Evelyne – sequence: 6 fullname: Bizot, Jean C – sequence: 7 fullname: Smith, Desmond – sequence: 8 fullname: Rubin, Edward – sequence: 9 fullname: Gillet, Brigitte – sequence: 10 fullname: Arbones, Mariona – sequence: 11 fullname: Delabar, Jean M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19242551$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1627367$$D View this record in Osti.gov |
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| Cites_doi | 10.1074/jbc.M513497200 10.1016/j.neuron.2005.09.005 10.1016/j.cell.2005.03.034 10.1042/bj3550597 10.1016/S0896-6273(03)00674-3 10.1007/s10519-004-5584-3 10.1128/MCB.22.18.6636-6647.2002 10.1038/sj.mp.4001957 10.1038/ng1095-177 10.1016/S0161-813X(02)00079-7 10.1093/jnen/63.5.429 10.1021/jf062816a 10.1006/geno.1997.5146 10.1523/JNEUROSCI.1521-05.2005 10.1016/S0304-3940(98)00317-6 10.1126/science.1114535 10.1038/ng0597-28 10.1523/JNEUROSCI.17-09-02959.1997 10.1136/jmg.2006.047373 10.1093/hmg/9.2.195 10.1038/35012518 10.1016/j.chroma.2006.11.088 10.1016/j.neuropharm.2005.02.012 10.1002/jnr.20193 10.1523/JNEUROSCI.1766-04.2004 10.1021/bi060632j 10.1093/humrep/del353 10.1016/S0028-3908(99)00083-0 10.1042/bj20021535 10.1016/j.neulet.2006.11.026 10.1159/000472398 10.1016/0896-6273(95)90286-4 10.1523/JNEUROSCI.0914-07.2007 10.1042/bj3550609 10.1002/ar.20640 10.1016/j.nbd.2005.02.004 10.1038/75698 10.1093/hmg/ddm022 10.1093/hmg/5.9.1305 10.1016/j.nbd.2005.12.006 10.1161/01.CIR.0000128034.70732.C2 10.1002/ajmg.a.31721 10.1016/S0306-4522(00)00428-0 10.1038/nn1860 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2009 Public Library of Science 2009 Guedj et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Guedj et al. 2009 |
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| DOI | 10.1371/journal.pone.0004606 |
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| References | N Murakami (ref8) 2006; Aug 18;281(33) WK Dowjat (ref10) 2007; Feb 8;413(1) YL Woods (ref9) 2001; May 1;355(Pt 3) LC Lin (ref28) 2007; Feb 21;55(4) F Tejedor (ref5) 1995; Feb;14(2) RM Escorihuela (ref14) 1998; May 15;247(2–3) I Branchi (ref20) 2004; May;63(5) YL Woods (ref7) 2001; May 1;355(Pt 3) B Bozon (ref33) 2003; Nov 13;40(4) F Fernandez (ref15) 2007; Apr;10(4) KO Chu (ref29) 2007; Jan;22(1) JM Delabar (ref1) 1993; 1(2) A Barco (ref36) 2005; Oct 6;48(1) RJ Siarey (ref39) 2005; Jul;49(1) C Chabert (ref21) 2004; Nov;34(6) K Aldridge (ref12) 2007; May 15;143A(10) DJ Yang (ref31) 2007; Jul 13;1156(1–2) W Xie (ref41) 2007 T Adayev (ref27) 2006; Oct 3;45(39) H Lee (ref44) 2004; Sep 15;77(6) V Fotaki (ref24) 2002; Sep;22(18) A Ronan (ref3) 2007; Jul;44(7) T Tanaka (ref42) 1997; May 1;17(9) SA Heldt (ref35) 2007; Jul;12(7) J Bain (ref26) 2003; 2003 Apr 1;371(Pt 1) R Benavides-Piccione (ref25) 2005; Oct;20(1) M Hattori (ref18) 2000; May 18;405(6784) DJ Smith (ref19) 1997; May;16(1) A O'Doherty (ref32) 2005; Sep 23;309(5743) RJ Siarey (ref38) 1999; Dec;38(12) JY Choi (ref30) 2002; Sep;23(3) K Olofsdotter (ref43) 2000; 101(3) LE Olson (ref16) 2007; Apr 1;16(7) J Hall (ref34) 2000; Jun;3(6) N Dahmane (ref17) 1998; Feb 15;48(1) JR Korenberg (ref2) 1997; 79(1–2) RH Reeves (ref13) 1995; 1995 Oct;11(2) AM Kleschevnikov (ref40) 2004; 2004 Sep 15;24(37) LL Baxter (ref11) 2000; Jan 22;9(2) C Sebrié (ref23) 2008; Mar;291(3) H Van Praag (ref37) 2007; May 30;27(22) K Rezai-Zadeh (ref46) 2005; Sep 21;25(38) KJ Ahn (ref22) 2006; Jun;22(3) J Guimera (ref4) 1996; Sep;5(9) KY Chyu (ref45) 2004; May 25;109(20) PA Lochhead (ref6) 2005; Jun 17;121(6) |
| References_xml | – volume: Aug 18;281(33) start-page: 23712 year: 2006 ident: ref8 article-title: Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. publication-title: J Biol Chem doi: 10.1074/jbc.M513497200 – volume: Oct 6;48(1) start-page: 123 year: 2005 ident: ref36 article-title: Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. publication-title: Neuron doi: 10.1016/j.neuron.2005.09.005 – volume: Jun 17;121(6) start-page: 925 year: 2005 ident: ref6 article-title: Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. publication-title: Cell doi: 10.1016/j.cell.2005.03.034 – volume: May 1;355(Pt 3) start-page: 597 year: 2001 ident: ref7 article-title: The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. publication-title: Biochem J doi: 10.1042/bj3550597 – volume: Nov 13;40(4) start-page: 695 year: 2003 ident: ref33 article-title: A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. publication-title: Neuron doi: 10.1016/S0896-6273(03)00674-3 – volume: Nov;34(6) start-page: 559 year: 2004 ident: ref21 article-title: Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1). publication-title: Behav Genet doi: 10.1007/s10519-004-5584-3 – volume: Sep;22(18) start-page: 6636 year: 2002 ident: ref24 article-title: Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. publication-title: Mol Cell Biol doi: 10.1128/MCB.22.18.6636-6647.2002 – volume: Jul;12(7) start-page: 656 year: 2007 ident: ref35 article-title: Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001957 – volume: 1995 Oct;11(2) start-page: 177 year: 1995 ident: ref13 article-title: A mouse model for Down syndrome exhibits learning and behaviour deficits. publication-title: Nat Genet doi: 10.1038/ng1095-177 – volume: Sep;23(3) start-page: 367 year: 2002 ident: ref30 article-title: Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. publication-title: Neurotoxicology doi: 10.1016/S0161-813X(02)00079-7 – volume: May;63(5) start-page: 429 year: 2004 ident: ref20 article-title: Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/63.5.429 – volume: Feb 21;55(4) start-page: 1517 year: 2007 ident: ref28 article-title: Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution. publication-title: J Agric Food Chem doi: 10.1021/jf062816a – volume: Feb 15;48(1) start-page: 12 year: 1998 ident: ref17 article-title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. publication-title: Genomics doi: 10.1006/geno.1997.5146 – volume: Sep 21;25(38) start-page: 8807 year: 2005 ident: ref46 article-title: Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1521-05.2005 – volume: May 15;247(2–3) start-page: 171 year: 1998 ident: ref14 article-title: Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. publication-title: Neurosci Lett doi: 10.1016/S0304-3940(98)00317-6 – volume: Sep 23;309(5743) start-page: 2033 year: 2005 ident: ref32 article-title: An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. publication-title: Science doi: 10.1126/science.1114535 – volume: May;16(1) start-page: 28 year: 1997 ident: ref19 article-title: Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. publication-title: Nat Genet doi: 10.1038/ng0597-28 – volume: May 1;17(9) start-page: 2959 year: 1997 ident: ref42 article-title: Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.17-09-02959.1997 – volume: Jul;44(7) start-page: 448 year: 2007 ident: ref3 article-title: Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region. publication-title: J Med Genet doi: 10.1136/jmg.2006.047373 – volume: Jan 22;9(2) start-page: 195 year: 2000 ident: ref11 article-title: Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. publication-title: Hum Mol Genet doi: 10.1093/hmg/9.2.195 – volume: May 18;405(6784) start-page: 311 year: 2000 ident: ref18 article-title: The DNA sequence of human chromosome 21. publication-title: Nature doi: 10.1038/35012518 – volume: Jul 13;1156(1–2) start-page: 312 year: 2007 ident: ref31 article-title: Effects of different steeping methods and storage on caffeine, catechins and gallic acid in bag tea infusions. publication-title: J Chromatogr A doi: 10.1016/j.chroma.2006.11.088 – volume: Jul;49(1) start-page: 122 year: 2005 ident: ref39 article-title: Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2005.02.012 – volume: Sep 15;77(6) start-page: 892 year: 2004 ident: ref44 article-title: Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. publication-title: J Neurosci Res doi: 10.1002/jnr.20193 – volume: 2004 Sep 15;24(37) start-page: 8153 year: 2004 ident: ref40 article-title: Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1766-04.2004 – volume: Oct 3;45(39) start-page: 12011 year: 2006 ident: ref27 article-title: Kinetic properties of a MNB/DYRK1A mutant suitable for the elucidation of biochemical pathways. publication-title: Biochemistry doi: 10.1021/bi060632j – volume: Jan;22(1) start-page: 280 year: 2007 ident: ref29 article-title: Uptake and distribution of catechins in fetal organs following in utero exposure in rats. publication-title: Hum Reprod doi: 10.1093/humrep/del353 – volume: Dec;38(12) start-page: 1917 year: 1999 ident: ref38 article-title: Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. publication-title: Neuropharmacology doi: 10.1016/S0028-3908(99)00083-0 – volume: 2003 Apr 1;371(Pt 1) start-page: 199 year: 2003 ident: ref26 article-title: The specificities of protein kinase inhibitors: an update. publication-title: Biochem J doi: 10.1042/bj20021535 – volume: Feb 8;413(1) start-page: 77 year: 2007 ident: ref10 article-title: Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. publication-title: Neurosci Lett doi: 10.1016/j.neulet.2006.11.026 – volume: 79(1–2) start-page: 21 year: 1997 ident: ref2 article-title: Report and abstracts of the Sixth International Workshop on Human Chromosome 21 Mapping. Cold Spring Harbor, New York, USA. May 6–8,1996. publication-title: Cytogenet Cell Genet – volume: 1(2) start-page: 114 year: 1993 ident: ref1 article-title: Molecular mapping of twenty-four features of Down syndrome on chromosome 21. publication-title: Eur J Hum Genet doi: 10.1159/000472398 – volume: Feb;14(2) start-page: 287 year: 1995 ident: ref5 article-title: Minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila. publication-title: Neuron doi: 10.1016/0896-6273(95)90286-4 – volume: May 30;27(22) start-page: 5869 year: 2007 ident: ref37 article-title: Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0914-07.2007 – volume: May 1;355(Pt 3) start-page: 609 year: 2001 ident: ref9 article-title: The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. publication-title: Biochem J doi: 10.1042/bj3550609 – volume: Mar;291(3) start-page: 254 year: 2008 ident: ref23 article-title: Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21. publication-title: Anat Records (Hoboken) doi: 10.1002/ar.20640 – volume: Oct;20(1) start-page: 115 year: 2005 ident: ref25 article-title: Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse. publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2005.02.004 – volume: Jun;3(6) start-page: 533 year: 2000 ident: ref34 article-title: Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. publication-title: Nat Neurosci doi: 10.1038/75698 – volume: Apr 1;16(7) start-page: 774 year: 2007 ident: ref16 article-title: Trisomy for the Down syndrome ‘critical region’ is necessary but not sufficient for brain phenotypes of trisomic mice. publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm022 – volume: Sep;5(9) start-page: 1305 year: 1996 ident: ref4 article-title: A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. publication-title: Hum Mol Genet doi: 10.1093/hmg/5.9.1305 – volume: Jun;22(3) start-page: 463 year: 2006 ident: ref22 article-title: DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2005.12.006 – volume: May 25;109(20) start-page: 2448 year: 2004 ident: ref45 article-title: Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. publication-title: Circulation doi: 10.1161/01.CIR.0000128034.70732.C2 – volume: May 15;143A(10) start-page: 1060 year: 2007 ident: ref12 article-title: Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.31721 – year: 2007 ident: ref41 article-title: Promotion of Neuronal Plasticity by (–)-Epigallocatechin-5 3-Gallate. publication-title: Neurochem Res – volume: 101(3) start-page: 531 year: 2000 ident: ref43 article-title: Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor. publication-title: Neuroscience doi: 10.1016/S0306-4522(00)00428-0 – volume: Apr;10(4) start-page: 411 year: 2007 ident: ref15 article-title: Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. publication-title: Nat Neurosci doi: 10.1038/nn1860 |
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| Snippet | Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain... Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain... |
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| SubjectTerms | Alterations analogs & derivatives Analysis Angiogenesis Animals antagonists & inhibitors Antioxidants Antioxidants - pharmacology Apolipoproteins Artificial chromosomes Atherosclerosis BASIC BIOLOGICAL SCIENCES Biology Brain Brain - growth & development Brain-derived neurotrophic factor Catechin Catechin - analogs & derivatives Catechin - pharmacology Cell cycle Cell density Consolidation Defects Developmental Biology/Neurodevelopment diet Dosage Down syndrome Down's syndrome Dyrk Kinases DYRK1A gene Edema Epigallocatechin gallate Epigallocatechin-3-gallate Flavonoids Flavonoids - pharmacology Gene Dosage gene overexpression Genes Genetic engineering genetically modified animals genetics Genomes Gestation Green tea growth & development hippocampus Humans Intellectual disabilities Ischemia Kinases Learning Magnetic resonance imaging Memory Mice Mice, Transgenic Morphogenesis Morphology mouse models Neurological Disorders/Cognitive Neurology and Dementia Neuronal Plasticity neuroprotective effect Neuroscience/Neuronal Signaling Mechanisms pharmacology Phenols Phenols - pharmacology physiology Polyphenols protein kinases Protein Serine-Threonine Kinases Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - physiology Protein-Tyrosine Kinases Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - physiology Proteins Rodents Synaptic plasticity Tea Transgenic animals Transgenic mice visual object recognition volume |
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| Title | Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A |
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