Genetic variation in human NPY expression affects stress response and emotion

• Published in: Nature Vol. 452; no. 7190; pp. 997 - 1001
• Main Authors: Zhou, Zhifeng, Zhu, Guanshan, Hariri, Ahmad R., Enoch, Mary-Anne, Scott, David, Sinha, Rajita, Virkkunen, Matti, Mash, Deborah C., Lipsky, Robert H., Hu, Xian-Zhang, Hodgkinson, Colin A., Xu, Ke, Buzas, Beata, Yuan, Qiaoping, Shen, Pei-Hong, Ferrell, Robert E., Manuck, Stephen B., Brown, Sarah M., Hauger, Richard L., Stohler, Christian S., Zubieta, Jon-Kar, Goldman, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.04.2008; Nature Publishing; Nature Publishing Group
• Subjects: Alleles; Anxiety - genetics; Anxiety Disorders - genetics; Behavior; Biological and medical sciences; Brain; Brain - metabolism; Brain - physiology; Brain - physiopathology; Emotions; Facial Expression; Finland - ethnology; Gene Expression Regulation - genetics; Genes; Genetic diversity; Genetic Variation - genetics; Haplotypes - genetics; Humanities and Social Sciences; Humans; letter; Lymphocytes - metabolism; Magnetic Resonance Imaging; Male; Medical imaging; Medical sciences; multidisciplinary; Neurology; Neuropeptide Y - blood; Neuropeptide Y - genetics; Neuropharmacology; Opioid Peptides - metabolism; Pain - genetics; Peptides; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide - genetics; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Regression analysis; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Stress, Physiological - genetics; Stress, Physiological - psychology; United States - ethnology; Variance analysis; White People - genetics; United States; Finland; Human; Neuropeptide Y; Affect affectivity; Genetic variability; Psychotropic; Central nervous system; Basal ganglion; Emotion emotionality; Limbic system; Genetic determinism; Stress; Encephalon; Phenotype; Treatment; Interindividual comparison; Arousal; Genetics; Behavior; Release

The Y factor An individual's ability to deal with stress and anxiety — risk factors for many diseases — varies widely across human populations and the factors contributing to emotional resilience are complex. A study led by researchers at the National Institute on Alcohol Abuse and Alcoholism n...