A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration

Studies completed to date provide persuasive evidence that placental cell-derived exosomes play a significant role in intercellular communication pathways that potentially contribute to placentation and development of materno-fetal vascular circulation. The aim of this study was to establish the ges...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 9; no. 6; p. e98667
Main Authors Salomon, Carlos, Torres, Maria Jose, Kobayashi, Miharu, Scholz-Romero, Katherin, Sobrevia, Luis, Dobierzewska, Aneta, Illanes, Sebastian E, Mitchell, Murray D, Rice, Gregory E
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 06.06.2014
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Studies completed to date provide persuasive evidence that placental cell-derived exosomes play a significant role in intercellular communication pathways that potentially contribute to placentation and development of materno-fetal vascular circulation. The aim of this study was to establish the gestational-age release profile and bioactivity of placental cell-derived exosome in maternal plasma. Plasma samples (n = 20 per pregnant group) were obtained from non-pregnant and pregnant women in the first (FT, 6-12 weeks), second (ST, 22-24 weeks) and third (TT, 32-38 weeks) trimester. The number of exosomes and placental exosome contribution were determined by quantifying immunoreactive exosomal CD63 and placenta-specific marker (PLAP), respectively. The effect of exosomes isolated from FT, ST and TT on endothelial cell migration were established using a real-time, live-cell imaging system (Incucyte). Exosome plasma concentration was more than 50-fold greater in pregnant women than in non-pregnant women (p<0.001). During normal healthy pregnancy, the number of exosomes present in maternal plasma increased significantly with gestational age by more that two-fold (p<0.001). Exosomes isolated from FT, ST and TT increased endothelial cell migration by 1.9±0.1, 1.6±0.2 and 1.3±0.1-fold, respectively compared to the control. Pregnancy is associated with a dramatic increase in the number of exosomes present in plasma and maternal plasma exosomes are bioactive. While the role of placental cell-derived exosome in regulating maternal and/or fetal vascular responses remains to be elucidated, changes in exosome profile may be of clinical utility in the diagnosis of placental dysfunction.
AbstractList Studies completed to date provide persuasive evidence that placental cell-derived exosomes play a significant role in intercellular communication pathways that potentially contribute to placentation and development of materno-fetal vascular circulation. The aim of this study was to establish the gestational-age release profile and bioactivity of placental cell-derived exosome in maternal plasma. Plasma samples (n = 20 per pregnant group) were obtained from non-pregnant and pregnant women in the first (FT, 6–12 weeks), second (ST, 22–24 weeks) and third (TT, 32–38 weeks) trimester. The number of exosomes and placental exosome contribution were determined by quantifying immunoreactive exosomal CD63 and placenta-specific marker (PLAP), respectively. The effect of exosomes isolated from FT, ST and TT on endothelial cell migration were established using a real-time, live-cell imaging system (Incucyte). Exosome plasma concentration was more than 50-fold greater in pregnant women than in non-pregnant women (p<0.001). During normal healthy pregnancy, the number of exosomes present in maternal plasma increased significantly with gestational age by more that two-fold (p<0.001). Exosomes isolated from FT, ST and TT increased endothelial cell migration by 1.9±0.1, 1.6±0.2 and 1.3±0.1-fold, respectively compared to the control. Pregnancy is associated with a dramatic increase in the number of exosomes present in plasma and maternal plasma exosomes are bioactive. While the role of placental cell-derived exosome in regulating maternal and/or fetal vascular responses remains to be elucidated, changes in exosome profile may be of clinical utility in the diagnosis of placental dysfunction.
Audience Academic
Author Kobayashi, Miharu
Illanes, Sebastian E
Sobrevia, Luis
Mitchell, Murray D
Scholz-Romero, Katherin
Rice, Gregory E
Salomon, Carlos
Dobierzewska, Aneta
Torres, Maria Jose
AuthorAffiliation 3 Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
VU University Medical Center, Netherlands
2 Department of Obstetric and Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
1 University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
AuthorAffiliation_xml – name: 2 Department of Obstetric and Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
– name: 1 University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
– name: VU University Medical Center, Netherlands
– name: 3 Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Author_xml – sequence: 1
  givenname: Carlos
  surname: Salomon
  fullname: Salomon, Carlos
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
– sequence: 2
  givenname: Maria Jose
  surname: Torres
  fullname: Torres, Maria Jose
  organization: Department of Obstetric and Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
– sequence: 3
  givenname: Miharu
  surname: Kobayashi
  fullname: Kobayashi, Miharu
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
– sequence: 4
  givenname: Katherin
  surname: Scholz-Romero
  fullname: Scholz-Romero, Katherin
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
– sequence: 5
  givenname: Luis
  surname: Sobrevia
  fullname: Sobrevia, Luis
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia; Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
– sequence: 6
  givenname: Aneta
  surname: Dobierzewska
  fullname: Dobierzewska, Aneta
  organization: Department of Obstetric and Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
– sequence: 7
  givenname: Sebastian E
  surname: Illanes
  fullname: Illanes, Sebastian E
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia; Department of Obstetric and Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
– sequence: 8
  givenname: Murray D
  surname: Mitchell
  fullname: Mitchell, Murray D
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
– sequence: 9
  givenname: Gregory E
  surname: Rice
  fullname: Rice, Gregory E
  organization: University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women's Hospital, Queensland, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24905832$$D View this record in MEDLINE/PubMed
BookMark eNqNk9uK2zAQhk3Z0t1N-walNRRKe5FURx9uCmHpIbCw0NOtmMjjREG2spJdtm9fOfEucdmLoguL8Tf_SL9mLpOz1rWYJC8pWVCe0w871_sW7GIfwwtCyiLL8ifJBS05m2eM8LOT_XlyGcKOEMkj9Sw5Z6IksuDsImmX6QZDB51xUSzde1cbi6mr070FjW0Xg3jngmswpKZNG-jQH0gLoYEU2irttmh8inWNugupa1NsKxeD1kROo7VpYzb-UOJ58rQGG_DF-J0lPz9_-nH1dX5982V1tbye61zwbs7LnEiUmtQZSsoZCFkWZc6g4lVGOXIAQjIkGSHrklBZQs2oZKDXBZQyL_gseX3U3VsX1GhVUFRynguZs4FYHYnKwU7tvWnA_1EOjDoEnN8o8J3RFhUtSalrTRhwLXSegcS1Zgy5rBitCIlaH8dq_brBarDNg52ITv-0Zqs27rcSRBTx4FHg3Sjg3W0f30M1JgzOQYuuP5xbiFyIUkT0zT_o47cbqQ3EC5i2drGuHkTVUtAiJzmLvs6SxSNUXBU2Rse-GnphmvB-khCZDu-6DfQhqNX3b__P3vyasm9P2C2C7bbB2X5omTAFxRHU3oXgsX4wmRI1jMW9G2oYCzWORUx7dfpAD0n3c8D_Av8dCUM
CitedBy_id crossref_primary_10_1016_j_jri_2016_08_008
crossref_primary_10_1038_s41581_022_00586_9
crossref_primary_10_1016_j_placenta_2018_10_009
crossref_primary_10_1016_j_ajog_2019_06_010
crossref_primary_10_1038_srep30632
crossref_primary_10_3390_ijms222111831
crossref_primary_10_1111_aji_12860
crossref_primary_10_1113_JP282849
crossref_primary_10_1186_s12967_021_02999_9
crossref_primary_10_3390_ijms221910343
crossref_primary_10_1016_j_placenta_2018_02_006
crossref_primary_10_1371_journal_pone_0235214
crossref_primary_10_2337_db15_0966
crossref_primary_10_3390_ijms22042055
crossref_primary_10_1042_CS20191155
crossref_primary_10_1080_14767058_2021_2000598
crossref_primary_10_1161_HYPERTENSIONAHA_122_19244
crossref_primary_10_1007_s10238_022_00854_9
crossref_primary_10_3389_fphys_2021_708824
crossref_primary_10_1016_j_jri_2023_104187
crossref_primary_10_1016_j_theriogenology_2018_08_020
crossref_primary_10_1210_endocr_bqad013
crossref_primary_10_1016_j_ajog_2020_10_023
crossref_primary_10_1080_15592294_2021_1899887
crossref_primary_10_3390_ijms25031538
crossref_primary_10_1038_srep31172
crossref_primary_10_1016_j_placenta_2021_02_012
crossref_primary_10_3390_cells12020209
crossref_primary_10_1038_s41380_022_01794_2
crossref_primary_10_1371_journal_pone_0174514
crossref_primary_10_1016_j_bbamcr_2014_12_038
crossref_primary_10_1042_CS20220149
crossref_primary_10_1186_s12014_022_09342_4
crossref_primary_10_1016_j_placenta_2019_12_016
crossref_primary_10_1016_j_biochi_2023_04_005
crossref_primary_10_3390_biomedicines9091257
crossref_primary_10_15690_vramn1369
crossref_primary_10_1007_s00109_022_02278_0
crossref_primary_10_1213_ANE_0000000000005898
crossref_primary_10_1038_s41598_018_37002_x
crossref_primary_10_1080_20013078_2020_1812261
crossref_primary_10_1016_j_clinbiochem_2015_03_004
crossref_primary_10_1111_aji_13297
crossref_primary_10_1186_s12964_022_00853_z
crossref_primary_10_3389_fphys_2020_594313
crossref_primary_10_1016_j_placenta_2020_03_002
crossref_primary_10_3390_jpm12081324
crossref_primary_10_23868_201707024
crossref_primary_10_3390_ijms22042158
crossref_primary_10_3390_cells12192347
crossref_primary_10_3390_ijms23063186
crossref_primary_10_1016_j_placenta_2022_12_005
crossref_primary_10_1111_aji_13857
crossref_primary_10_1002_smll_201702153
crossref_primary_10_1016_j_intimp_2020_106981
crossref_primary_10_1071_RD15143
crossref_primary_10_2147_IJWH_S382836
crossref_primary_10_1016_j_isci_2023_108046
crossref_primary_10_2217_bmm_2018_0468
crossref_primary_10_1111_aji_13860
crossref_primary_10_1093_humupd_dmv006
crossref_primary_10_1016_j_mehy_2020_109721
crossref_primary_10_1071_AN18579
crossref_primary_10_1186_s12920_019_0590_8
crossref_primary_10_1016_j_cca_2022_12_021
crossref_primary_10_1016_j_placenta_2023_06_014
crossref_primary_10_3390_ijms22094640
crossref_primary_10_1080_15592294_2017_1358345
crossref_primary_10_1186_s40001_023_01598_2
crossref_primary_10_3389_fphys_2016_00098
crossref_primary_10_1371_journal_pone_0157614
crossref_primary_10_3389_fphar_2022_895254
crossref_primary_10_1016_j_placenta_2024_03_010
crossref_primary_10_1210_en_2018_00073
crossref_primary_10_1038_s41598_017_14180_8
crossref_primary_10_1161_HYPERTENSIONAHA_123_20907
crossref_primary_10_1042_CS20220484
crossref_primary_10_1002_mrd_22847
crossref_primary_10_1155_2021_4632745
crossref_primary_10_3390_ijms25105102
crossref_primary_10_1002_jev2_12377
crossref_primary_10_1007_s00281_019_00772_1
crossref_primary_10_2139_ssrn_3960260
crossref_primary_10_1007_s11892_017_0856_5
crossref_primary_10_1016_j_placenta_2017_11_011
crossref_primary_10_1021_acs_analchem_3c00772
crossref_primary_10_3389_fvets_2020_589117
crossref_primary_10_1016_j_mam_2021_100955
crossref_primary_10_1038_srep40476
crossref_primary_10_1016_j_ajog_2015_07_010
crossref_primary_10_3389_fimmu_2019_00718
crossref_primary_10_1007_s40618_020_01262_0
crossref_primary_10_3390_ijms22158163
crossref_primary_10_1111_imr_13074
crossref_primary_10_1016_j_trsl_2019_03_008
crossref_primary_10_1002_jev2_12266
crossref_primary_10_1038_s41598_021_92180_5
crossref_primary_10_1111_cei_13304
crossref_primary_10_3892_ijmm_2018_3367
crossref_primary_10_1073_pnas_1617601114
crossref_primary_10_1111_aji_13361
crossref_primary_10_12677_ACM_2023_131128
crossref_primary_10_1007_s00281_020_00807_y
crossref_primary_10_1038_s41598_021_82752_w
crossref_primary_10_1155_2020_3521859
crossref_primary_10_1016_j_cytogfr_2023_12_004
crossref_primary_10_1155_2014_693157
crossref_primary_10_1016_j_preghy_2017_09_002
crossref_primary_10_1080_02770903_2022_2134794
crossref_primary_10_1016_j_placenta_2016_08_078
crossref_primary_10_1016_j_placenta_2024_01_004
crossref_primary_10_1155_2022_2169259
crossref_primary_10_1093_jas_skac123
crossref_primary_10_1042_BST20220734
crossref_primary_10_1289_ehp_124_A124
crossref_primary_10_1016_j_placenta_2024_02_007
crossref_primary_10_1210_jc_2015_2270
crossref_primary_10_3389_fphys_2021_619137
crossref_primary_10_3390_v6114609
crossref_primary_10_1186_s12918_015_0182_y
crossref_primary_10_1016_j_gene_2019_01_012
crossref_primary_10_1038_s41598_017_06178_z
crossref_primary_10_1002_pmic_202200107
crossref_primary_10_1002_biof_1497
crossref_primary_10_1096_fj_201902522RR
crossref_primary_10_1093_humrep_dex310
crossref_primary_10_3389_fcvm_2022_1061340
crossref_primary_10_1111_jcmm_15144
crossref_primary_10_3390_ijms21062120
crossref_primary_10_2139_ssrn_4166173
crossref_primary_10_1186_s12958_016_0207_4
crossref_primary_10_1007_s11010_021_04351_7
crossref_primary_10_1371_journal_pone_0267564
crossref_primary_10_1016_j_placenta_2016_12_011
crossref_primary_10_1042_CS20180425
crossref_primary_10_1186_s12989_020_00359_x
crossref_primary_10_1111_aji_13312
crossref_primary_10_1186_s12964_023_01286_y
crossref_primary_10_1093_infdis_jiy550
crossref_primary_10_1371_journal_pone_0210675
crossref_primary_10_3389_fimmu_2023_1198430
crossref_primary_10_1155_2018_4302096
crossref_primary_10_1128_mbio_00951_22
crossref_primary_10_2139_ssrn_4060722
crossref_primary_10_1002_pmic_201800164
crossref_primary_10_1371_journal_pone_0218270
crossref_primary_10_2147_IJN_S396194
crossref_primary_10_1152_ajpregu_00072_2018
crossref_primary_10_1210_jc_2018_02693
crossref_primary_10_3389_fcell_2022_931609
crossref_primary_10_1016_j_placenta_2023_07_006
crossref_primary_10_1038_s41598_017_16448_5
crossref_primary_10_1038_s41598_021_00430_3
crossref_primary_10_1016_j_placenta_2016_12_002
crossref_primary_10_1016_j_placenta_2016_12_001
crossref_primary_10_1038_s41598_017_07017_x
crossref_primary_10_1152_physrev_00050_2021
crossref_primary_10_3168_jds_2016_11060
crossref_primary_10_1038_s41598_017_12491_4
crossref_primary_10_3389_fvets_2021_654064
crossref_primary_10_1186_1479_5876_12_204
crossref_primary_10_1161_HYPERTENSIONAHA_119_12707
crossref_primary_10_3168_jds_2016_12152
crossref_primary_10_1242_dev_187013
crossref_primary_10_1016_j_cyto_2023_156190
crossref_primary_10_1038_s44321_024_00045_x
crossref_primary_10_3389_fcell_2023_1080419
crossref_primary_10_3389_fendo_2023_1097337
crossref_primary_10_1016_j_xagr_2024_100319
crossref_primary_10_1016_j_biomaterials_2018_10_045
crossref_primary_10_1042_CS20220301
crossref_primary_10_1097_MD_0000000000031583
crossref_primary_10_1248_cpb_c22_00072
crossref_primary_10_1016_j_medntd_2022_100179
crossref_primary_10_1007_s43032_024_01491_1
crossref_primary_10_3892_etm_2022_11518
crossref_primary_10_1161_HYPERTENSIONAHA_117_09321
crossref_primary_10_1021_acssensors_3c00689
crossref_primary_10_1007_s10304_023_00534_1
crossref_primary_10_1095_biolreprod_115_134973
crossref_primary_10_3168_jds_2015_10786
crossref_primary_10_1002_jcp_26259
crossref_primary_10_1213_ANE_0000000000005812
crossref_primary_10_1038_s41598_023_31425_x
crossref_primary_10_1093_biolre_ioaa152
crossref_primary_10_1016_j_placenta_2020_10_033
crossref_primary_10_4103_ijmr_ijmr_2143_22
crossref_primary_10_1016_j_heliyon_2023_e15593
crossref_primary_10_1007_s43032_024_01591_y
crossref_primary_10_1111_aji_13345
crossref_primary_10_1016_j_ajog_2015_07_001
crossref_primary_10_3390_ijms22083904
crossref_primary_10_3389_fendo_2019_00563
crossref_primary_10_1007_s00441_016_2358_1
crossref_primary_10_1210_er_2017_00229
crossref_primary_10_3389_fcell_2022_918080
crossref_primary_10_3389_fendo_2017_00239
crossref_primary_10_1016_j_placenta_2019_10_008
crossref_primary_10_1186_s12967_016_0935_4
crossref_primary_10_1007_s43032_021_00556_9
crossref_primary_10_1210_endocr_bqaa009
crossref_primary_10_1016_j_placenta_2020_05_007
crossref_primary_10_1038_s41598_018_23706_7
crossref_primary_10_1172_jci_insight_98942
crossref_primary_10_2174_1381612825666191206162712
crossref_primary_10_1097_FM9_0000000000000093
crossref_primary_10_1371_journal_pone_0118629
crossref_primary_10_3389_fendo_2017_00196
crossref_primary_10_1038_s41598_020_74078_w
crossref_primary_10_1111_aji_12788
crossref_primary_10_3390_ijms21207568
crossref_primary_10_3390_cells8111459
crossref_primary_10_1038_s41392_020_00258_9
crossref_primary_10_3168_jds_2017_14190
crossref_primary_10_1016_j_heliyon_2019_e02355
crossref_primary_10_3389_fcell_2021_646326
crossref_primary_10_1016_j_placenta_2016_11_008
crossref_primary_10_1111_jcmm_17056
crossref_primary_10_3892_ijmm_2020_4626
crossref_primary_10_1210_en_2018_00820
crossref_primary_10_3390_ijms25041947
crossref_primary_10_24075_brsmu_2024_010
crossref_primary_10_1016_j_placenta_2017_01_119
crossref_primary_10_1093_jleuko_qiad022
crossref_primary_10_1016_j_mam_2017_12_002
crossref_primary_10_1002_jex2_135
crossref_primary_10_1111_aji_13521
crossref_primary_10_3389_fcell_2022_1060850
crossref_primary_10_1016_j_placenta_2020_06_011
crossref_primary_10_1016_j_bbrc_2019_08_015
crossref_primary_10_3390_ijms22105402
crossref_primary_10_3390_ijms24065658
crossref_primary_10_3389_fcell_2023_1135821
crossref_primary_10_1210_jc_2017_00672
crossref_primary_10_1016_j_theriogenology_2020_01_083
crossref_primary_10_12750_JARB_37_1_2
crossref_primary_10_1002_jcp_28668
crossref_primary_10_1111_jdi_13493
crossref_primary_10_1016_j_placenta_2017_06_004
crossref_primary_10_3390_ijms232113115
crossref_primary_10_1186_s12967_020_02227_w
crossref_primary_10_1016_j_imbio_2016_03_001
crossref_primary_10_3390_cells9030675
crossref_primary_10_1038_s41419_018_0713_8
crossref_primary_10_1155_2018_6380463
crossref_primary_10_1042_CS20220150
crossref_primary_10_3389_fmed_2021_758971
crossref_primary_10_1042_EBC20170087
crossref_primary_10_2147_DMSO_S363226
crossref_primary_10_3390_biomedicines11030857
crossref_primary_10_1128_mSphere_00192_21
crossref_primary_10_1007_s12020_021_02938_0
crossref_primary_10_2527_jas_2017_1727
crossref_primary_10_1016_j_ebiom_2021_103253
crossref_primary_10_1016_j_placenta_2016_09_008
crossref_primary_10_3390_ijms20122890
crossref_primary_10_3390_ijms21124264
crossref_primary_10_18632_oncotarget_7052
crossref_primary_10_1016_j_ajog_2019_01_220
crossref_primary_10_1007_s00109_022_02236_w
crossref_primary_10_17816_aog623622
crossref_primary_10_1210_en_2018_00836
crossref_primary_10_3389_fendo_2022_1024587
crossref_primary_10_3389_fimmu_2021_758281
crossref_primary_10_3389_fendo_2022_809596
crossref_primary_10_3390_ijms24119431
crossref_primary_10_3390_pharmaceutics13010122
crossref_primary_10_1186_s13287_022_02874_4
crossref_primary_10_3389_fphar_2022_1001652
Cites_doi 10.1095/biolreprod.108.075481
10.1002/pmic.200800109
10.1016/j.icarus.2005.08.024
10.1371/journal.pone.0079636
10.1111/j.1600-0897.2006.00435.x
10.1038/nri855
10.4161/cib.18452
10.1016/j.placenta.2012.08.004
10.2337/db11-0155
10.1055/s-0030-1270342
10.1172/JCI66517
10.1111/j.1600-0897.2010.00822.x
10.1371/journal.pone.0068451
10.1158/0008-5472.CAN-09-2470
10.1016/j.placenta.2012.10.005
10.1586/epr.09.17
10.1016/j.placenta.2007.11.016
10.1038/sj.bjc.6602316
10.1016/j.placenta.2011.12.006
10.1016/j.icarus.2005.12.023
10.1002/9781444393927.ch7
10.1073/pnas.1304718110
10.4049/jimmunol.176.6.3585
10.1242/jcs.113.19.3365
10.1016/j.biocel.2011.10.005
10.1093/molehr/gas013
10.1159/000115355
10.1016/j.icarus.2005.10.035
10.1016/j.yexcr.2011.01.014
10.1111/j.1447-0756.2008.00719.x
10.1002/cyto.a.20886
10.1016/j.colsurfb.2011.05.013
10.3892/ijmm.2012.894
10.1111/j.1600-0897.2011.01079.x
10.1186/1755-8166-5-27
10.1111/j.1600-0897.2010.00880.x
10.1016/j.ymeth.2012.01.002
ContentType Journal Article
Copyright COPYRIGHT 2014 Public Library of Science
2014 Salomon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2014 Salomon et al 2014 Salomon et al
Copyright_xml – notice: COPYRIGHT 2014 Public Library of Science
– notice: 2014 Salomon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2014 Salomon et al 2014 Salomon et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PIMPY
PQEST
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0098667
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Opposing Viewpoints Resource Center
Science in Context
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
ProQuest Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database (Proquest)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
Technology Collection
Technology Research Database
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList



Agricultural Science Database

MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
DocumentTitleAlternate Placental Exosomes in Maternal Circulation
EISSN 1932-6203
Editor Oudejans, Cees
Editor_xml – sequence: 1
  givenname: Cees
  surname: Oudejans
  fullname: Oudejans, Cees
EndPage e98667
ExternalDocumentID 1533745728
oai_doaj_org_article_1909cfc02a3c4c76a5ebc22e35d21d00
3327533361
A418707251
10_1371_journal_pone_0098667
24905832
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Queensland Australia
Australia
GeographicLocations_xml – name: Queensland Australia
– name: Australia
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RIG
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
CITATION
AFPKN
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PQEST
PQUKI
RC3
7X8
5PM
-
02
AAPBV
ABPTK
ADACO
BBAFP
KM
ID FETCH-LOGICAL-c743t-39705e5c0f6e5132a4598972ad3d613e3aa006e0600b90159af2152acb8a95783
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Fri Nov 26 17:13:13 EST 2021
Tue Oct 22 15:14:03 EDT 2024
Tue Sep 17 21:15:13 EDT 2024
Fri Oct 25 08:41:25 EDT 2024
Thu Oct 10 16:44:36 EDT 2024
Tue Nov 19 20:43:34 EST 2024
Tue Nov 12 23:22:53 EST 2024
Thu Aug 01 20:24:39 EDT 2024
Thu Aug 01 20:25:58 EDT 2024
Tue Aug 20 22:13:36 EDT 2024
Thu Nov 21 21:51:07 EST 2024
Tue Oct 15 23:55:25 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c743t-39705e5c0f6e5132a4598972ad3d613e3aa006e0600b90159af2152acb8a95783
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: CS GER. Performed the experiments: CS MJT MK KS. Analyzed the data: CS LS SEI AD MDM GER. Contributed reagents/materials/analysis tools: SEI MDM. Wrote the paper: CS GER.
Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048215/
PMID 24905832
PQID 1533745728
PQPubID 1436336
ParticipantIDs plos_journals_1533745728
doaj_primary_oai_doaj_org_article_1909cfc02a3c4c76a5ebc22e35d21d00
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4048215
proquest_miscellaneous_1534474494
proquest_journals_1533745728
gale_infotracmisc_A418707251
gale_infotracacademiconefile_A418707251
gale_incontextgauss_ISR_A418707251
gale_incontextgauss_IOV_A418707251
gale_healthsolutions_A418707251
crossref_primary_10_1371_journal_pone_0098667
pubmed_primary_24905832
PublicationCentury 2000
PublicationDate 2014-06-06
PublicationDateYYYYMMDD 2014-06-06
PublicationDate_xml – month: 06
  year: 2014
  text: 2014-06-06
  day: 06
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2014
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References 15655551 - Br J Cancer. 2005 Jan 31;92(2):305-11
21640565 - Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):146-50
16517727 - J Immunol. 2006 Mar 15;176(6):3585-92
22217911 - Placenta. 2012 Feb;33 Suppl:S48-54
20235276 - Cytometry A. 2010 Jun;77(6):502-14
20124479 - Cancer Res. 2010 Feb 15;70(4):1668-78
22999499 - Placenta. 2012 Nov;33(11):933-41
20560914 - Am J Reprod Immunol. 2011 Jan;65(1):65-77
19494253 - Biol Reprod. 2009 Oct;81(4):717-29
23818581 - Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12048-53
18192006 - Placenta. 2008 Mar;29 Suppl A:S73-7
22285593 - Methods. 2012 Feb;56(2):293-304
19489699 - Expert Rev Proteomics. 2009 Jun;6(3):267-83
20331583 - Am J Reprod Immunol. 2010 Jun;63(6):520-33
22011169 - Am J Reprod Immunol. 2012 Mar;67(3):206-15
24244532 - PLoS One. 2013;8(11):e79636
17076679 - Am J Reprod Immunol. 2006 Nov-Dec;56(5-6):345-55
21276792 - Exp Cell Res. 2011 May 1;317(8):1192-202
21515851 - Diabetes. 2011 Jun;60(6):1677-87
10984428 - J Cell Sci. 2000 Oct;113 Pt 19:3365-74
21370216 - Semin Thromb Hemost. 2011 Mar;37(2):146-52
22559272 - Mol Cytogenet. 2012 Jul 02;5(1):27
22482020 - Commun Integr Biol. 2012 Jan 1;5(1):88-93
18937701 - J Obstet Gynaecol Res. 2008 Aug;34(4):487-93
23454749 - J Clin Invest. 2013 Apr;123(4):1542-55
22024155 - Int J Biochem Cell Biol. 2012 Jan;44(1):11-5
22383544 - Mol Hum Reprod. 2012 Aug;18(8):417-24
18780348 - Proteomics. 2008 Oct;8(19):4083-99
23107341 - Placenta. 2012 Dec;33(12):982-90
12154376 - Nat Rev Immunol. 2002 Aug;2(8):569-79
18228490 - Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22
22294131 - Int J Mol Med. 2012 Apr;29(4):601-6
23861904 - PLoS One. 2013;8(7):e68451
18230895 - Front Horm Res. 2008;36:73-84
BJ Tauro (ref32) 2012; 56
C Salomon (ref30) 2013; 8
S Biswas (ref35) 2008; 34
A Sabapatha (ref20) 2006; 56
AF Orozco (ref22) 2010; 77A
AM Roccaro (ref16) 2013; 123
S-S Luo (ref23) 2009; 81
K Brinkfeldt (ref44) 2006; 182
ref1
ref17
S Atay (ref12) 2011; 317
JA van der Post (ref27) 2011; 37
CWG Redman (ref21) 2008; 29
K Denzer (ref13) 2000; 113
C Thery (ref5) 2002; 2
L Mincheva-Nilsson (ref2) 2010; 63
AK Ludwig (ref14) 2012; 44
Y Futaana (ref43) 2006; 182
JM Tolosa (ref19) 2012; 33
RB Donker (ref10) 2012; 18
A Sabapatha (ref34) 2006; 56
R Liersch (ref33) 2010; 33
JA Armitage (ref40) 2008; 36
C Salomon (ref7) 2013; 8
L Mincheva-Nilsson (ref18) 2006; 176
RJ Simpson (ref4) 2009; 6
CA Lok (ref28) 2012; 67
E Delorme-Axford (ref15) 2013; 110
V Sokolova (ref8) 2011; 87
J Bullerdiek (ref24) 2012; 5
RB Donker (ref25) 2012; 18
S Atay (ref39) 2011; 65
RJ Simpson (ref42) 2008; 8
Y Chen (ref37) 2012; 29
I Nazarenko (ref11) 2010; 70
S Atay (ref38) 2011; 317
CWG Redman (ref26) 2012; 33
F Westermeier (ref31) 2011; 60
DD Taylor (ref41) 2005; 92
ref3
FL Verweij (ref9) 2012; 5
R Lundin (ref36) 2006; 182
(ref29); 3
SS Luo (ref6) 2009; 81
References_xml – volume: 81
  start-page: 717
  year: 2009
  ident: ref6
  article-title: Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.108.075481
  contributor:
    fullname: SS Luo
– volume: 8
  start-page: 4083
  year: 2008
  ident: ref42
  article-title: Proteomic profiling of exosomes: current perspectives
  publication-title: Proteomics
  doi: 10.1002/pmic.200800109
  contributor:
    fullname: RJ Simpson
– volume: 182
  start-page: 413
  year: 2006
  ident: ref43
  article-title: First ENA observations at Mars: Subsolar ENA jet
  publication-title: Icarus
  doi: 10.1016/j.icarus.2005.08.024
  contributor:
    fullname: Y Futaana
– ident: ref3
– volume: 8
  start-page: e79636
  year: 2013
  ident: ref30
  article-title: Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0079636
  contributor:
    fullname: C Salomon
– volume: 56
  start-page: 345
  year: 2006
  ident: ref34
  article-title: Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences
  publication-title: Am J Reprod Immunol
  doi: 10.1111/j.1600-0897.2006.00435.x
  contributor:
    fullname: A Sabapatha
– volume: 2
  start-page: 569
  year: 2002
  ident: ref5
  article-title: Exosomes: composition, biogenesis and function
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri855
  contributor:
    fullname: C Thery
– volume: 5
  start-page: 88
  year: 2012
  ident: ref9
  article-title: Intracellular signalling controlled by the endosomal-exosomal pathway
  publication-title: Communitative and Intergrative Biology
  doi: 10.4161/cib.18452
  contributor:
    fullname: FL Verweij
– volume: 33
  start-page: 933
  year: 2012
  ident: ref19
  article-title: The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes
  publication-title: Placenta
  doi: 10.1016/j.placenta.2012.08.004
  contributor:
    fullname: JM Tolosa
– volume: 60
  start-page: 1677
  year: 2011
  ident: ref31
  article-title: Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium
  publication-title: Diabetes
  doi: 10.2337/db11-0155
  contributor:
    fullname: F Westermeier
– volume: 37
  start-page: 146
  year: 2011
  ident: ref27
  article-title: The functions of microparticles in pre-eclampsia
  publication-title: Semin Thromb Hemost
  doi: 10.1055/s-0030-1270342
  contributor:
    fullname: JA van der Post
– volume: 123
  start-page: 1542
  year: 2013
  ident: ref16
  article-title: BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
  publication-title: J Clin Invest
  doi: 10.1172/JCI66517
  contributor:
    fullname: AM Roccaro
– volume: 63
  start-page: 520
  year: 2010
  ident: ref2
  article-title: The role of placental exosomes in reproduction
  publication-title: Am J Reprod Immunol
  doi: 10.1111/j.1600-0897.2010.00822.x
  contributor:
    fullname: L Mincheva-Nilsson
– volume: 3
  ident: ref29
– volume: 8
  start-page: e68451
  year: 2013
  ident: ref7
  article-title: Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0068451
  contributor:
    fullname: C Salomon
– volume: 70
  start-page: 1668
  year: 2010
  ident: ref11
  article-title: Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation
  publication-title: Cancer Research
  doi: 10.1158/0008-5472.CAN-09-2470
  contributor:
    fullname: I Nazarenko
– ident: ref17
  doi: 10.1016/j.placenta.2012.10.005
– volume: 81
  start-page: 717
  year: 2009
  ident: ref23
  article-title: Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes
  publication-title: Biology of Reproduction
  doi: 10.1095/biolreprod.108.075481
  contributor:
    fullname: S-S Luo
– volume: 6
  start-page: 267
  year: 2009
  ident: ref4
  article-title: Exosomes: proteomic insights and diagnostic potential
  publication-title: Expert Review of Proteomics
  doi: 10.1586/epr.09.17
  contributor:
    fullname: RJ Simpson
– volume: 29
  start-page: S73
  year: 2008
  ident: ref21
  article-title: Circulating microparticles in normal pregnancy and pre-eclampsia
  publication-title: Placenta
  doi: 10.1016/j.placenta.2007.11.016
  contributor:
    fullname: CWG Redman
– volume: 92
  start-page: 305
  year: 2005
  ident: ref41
  article-title: Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6602316
  contributor:
    fullname: DD Taylor
– volume: 33
  start-page: S48
  year: 2012
  ident: ref26
  article-title: Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia
  publication-title: Placenta
  doi: 10.1016/j.placenta.2011.12.006
  contributor:
    fullname: CWG Redman
– volume: 182
  start-page: 439
  year: 2006
  ident: ref44
  article-title: First ENA observations at Mars: Solar-wind ENAs on the nightside
  publication-title: Icarus
  doi: 10.1016/j.icarus.2005.12.023
  contributor:
    fullname: K Brinkfeldt
– ident: ref1
  doi: 10.1002/9781444393927.ch7
– volume: 110
  start-page: 12048
  year: 2013
  ident: ref15
  article-title: Human placental trophoblasts confer viral resistance to recipient cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1304718110
  contributor:
    fullname: E Delorme-Axford
– volume: 176
  start-page: 3585
  year: 2006
  ident: ref18
  article-title: Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.6.3585
  contributor:
    fullname: L Mincheva-Nilsson
– volume: 113
  start-page: 3365
  year: 2000
  ident: ref13
  article-title: Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
  publication-title: Journal of Cell Science
  doi: 10.1242/jcs.113.19.3365
  contributor:
    fullname: K Denzer
– volume: 44
  start-page: 11
  year: 2012
  ident: ref14
  article-title: Exosomes: Small vesicles participating in intercellular communication
  publication-title: International Journal of Biochemistry & Cell Biology
  doi: 10.1016/j.biocel.2011.10.005
  contributor:
    fullname: AK Ludwig
– volume: 18
  start-page: 417
  year: 2012
  ident: ref25
  article-title: The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes
  publication-title: Mol Hum Reprod
  doi: 10.1093/molehr/gas013
  contributor:
    fullname: RB Donker
– volume: 36
  start-page: 73
  year: 2008
  ident: ref40
  article-title: Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity
  publication-title: Front Horm Res
  doi: 10.1159/000115355
  contributor:
    fullname: JA Armitage
– volume: 182
  start-page: 308
  year: 2006
  ident: ref36
  article-title: Ionospheric plasma acceleration at Mars: ASPERA-3 results
  publication-title: Icarus
  doi: 10.1016/j.icarus.2005.10.035
  contributor:
    fullname: R Lundin
– volume: 317
  start-page: 1192
  year: 2011
  ident: ref12
  article-title: Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells
  publication-title: Experimental Cell Research
  doi: 10.1016/j.yexcr.2011.01.014
  contributor:
    fullname: S Atay
– volume: 34
  start-page: 487
  year: 2008
  ident: ref35
  article-title: Surface area of chorionic villi of placentas: an index of intrauterine growth restriction of fetuses
  publication-title: J Obstet Gynaecol Res
  doi: 10.1111/j.1447-0756.2008.00719.x
  contributor:
    fullname: S Biswas
– volume: 317
  start-page: 1192
  year: 2011
  ident: ref38
  article-title: Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2011.01.014
  contributor:
    fullname: S Atay
– volume: 77A
  start-page: 502
  year: 2010
  ident: ref22
  article-title: Flow Cytometric Analysis of Circulating Microparticles in Plasma
  publication-title: Cytometry Part A
  doi: 10.1002/cyto.a.20886
  contributor:
    fullname: AF Orozco
– volume: 87
  start-page: 146
  year: 2011
  ident: ref8
  article-title: Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
  publication-title: Colloids Surf B Biointerfaces
  doi: 10.1016/j.colsurfb.2011.05.013
  contributor:
    fullname: V Sokolova
– volume: 29
  start-page: 601
  year: 2012
  ident: ref37
  article-title: miR-200b is involved in intestinal fibrosis of Crohn's disease
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2012.894
  contributor:
    fullname: Y Chen
– volume: 67
  start-page: 206
  year: 2012
  ident: ref28
  article-title: Microparticles of pregnant women and preeclamptic patients activate endothelial cells in the presence of monocytes
  publication-title: Am J Reprod Immunol
  doi: 10.1111/j.1600-0897.2011.01079.x
  contributor:
    fullname: CA Lok
– volume: 18
  start-page: 417
  year: 2012
  ident: ref10
  article-title: The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes
  publication-title: Molecular Human Reproduction
  doi: 10.1093/molehr/gas013
  contributor:
    fullname: RB Donker
– volume: 33
  start-page: 230
  year: 2010
  ident: ref33
  article-title: Osteopontin as a prognostic factor in acute myeloid leukemia
  publication-title: Onkologie
  contributor:
    fullname: R Liersch
– volume: 56
  start-page: 345
  year: 2006
  ident: ref20
  article-title: Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences
  publication-title: American Journal of Reproductive Immunology
  doi: 10.1111/j.1600-0897.2006.00435.x
  contributor:
    fullname: A Sabapatha
– volume: 5
  start-page: 27
  year: 2012
  ident: ref24
  article-title: Exosome-delivered microRNAs of “chromosome 19 microRNA cluster” as immunomodulators in pregnancy and tumorigenesis
  publication-title: Mol Cytogenet
  doi: 10.1186/1755-8166-5-27
  contributor:
    fullname: J Bullerdiek
– volume: 65
  start-page: 65
  year: 2011
  ident: ref39
  article-title: Trophoblast-derived exosomes mediate monocyte recruitment and differentiation
  publication-title: Am J Reprod Immunol
  doi: 10.1111/j.1600-0897.2010.00880.x
  contributor:
    fullname: S Atay
– volume: 56
  start-page: 293
  year: 2012
  ident: ref32
  article-title: Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
  publication-title: Methods
  doi: 10.1016/j.ymeth.2012.01.002
  contributor:
    fullname: BJ Tauro
SSID ssj0053866
Score 2.6239984
Snippet Studies completed to date provide persuasive evidence that placental cell-derived exosomes play a significant role in intercellular communication pathways that...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e98667
SubjectTerms Adult
Biological activity
Biology and Life Sciences
Biomarkers - metabolism
Cancer
CD63 antigen
Cell interactions
Cell migration
Cell Movement
Cell signaling
Diabetes
Endothelial cells
Endothelial Cells - cytology
Endothelium
Exosomes
Exosomes - metabolism
Female
Fetuses
Gestational Age
Gynecology
Humans
Laboratories
Lipids
Male
Medicine
Medicine and Health Sciences
Mothers
Obstetrics
Physiology
Placenta
Placenta - cytology
Plasma
Plasma - cytology
Pregnancy
Pregnant women
Womens health
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELXQnnpBlK8GCjUICTikzYftxMctoipIgAQU9WY5jtOu1HVWZFfi5zNje9MGVYID1_Ukys68sZ_t8TMhr4TMaxjYTNqxWqesaeq0EZ1NG65ZowtjWy8p9OmzOD1jH8_5-Y2rvrAmLMgDB8cdwYAlTWeyQpeGmUpobhtTFLbkbZG3WZitZ8V2MhX6YMhiIeJBubLKj2JcDle9s4cooSn8vfLXA5HX6x975dnqqh9uo5x_Vk7eGIpO7pG7kUPSefj2XXLHuvtkN2bpQN9EKem3D4ibU9w_igt-NF7QTfuO-losPAlJ7a9-6Jfw3MJRoK9eExqbh6Wm2rXUbyXQWPdBe0eta_HY1hUgl-K6P10uLgKOHpKzk_ff352m8YaF1ABzWKdARjJuuck6YTnMSzXjspZVoduyFbg-qjVkpc2AFTVIHKTu8B5cbZpaS8j18hGZOfDpHqGMWQ58wEpjWmZkKXUubS1QXsxK3nYJSbfuVqsgpKH8bloFE5DgN4XhUTE8CTnGmIy2KIPtfwBwqAgO9TdwJOQAI6rCmdIxmdWc5dBPVcDtEvLSW6AUhsNamwu9GQb14cuPfzD69nVi9DoadT1gw-h4vgH-E4Z2Yrk_sYSENpPmPcTf1iuDQkpeMV4VNTy5xeTtzS_GZnwp1s8522-8DWMVY5Il5HGA8OhZmIBnHDr2hFQTcE9cP21xi0uvRM6g_wdAPPkfsXpKdoCMMl-GJ_bJbP1zY58B4Vs3z31u_wYQuVQ9
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLagSIiXiY3LwgYYhAQ8ZMvFduInVKZ2A6kwwYb2FjmOUyp1Tre0Ej-fcxy3I2hCvNYnUXpu_mwff4eQN0LGOUxsOqxZrkJWlnlYitqEJVesVIk2laMUmnwRJ-fs8wW_8BturS-rXOdEl6irRuMe-SHikozxLMk_LK5C7BqFp6u-hcZdci9OMoElffn4eJ2JIZaF8Nfl0iw-9NY5WDTWHCCRpnDd5W-mI8fav8nNg8W8aW8Dnn_XT_4xIY0fki2PJOmwM_02uWPsDrk_8WflO2Tbh21L33lu6fePiB3SY9Mu_Q4gPe06dtOmpqe4n45XI-noV9M2l_DczNKJ6kiicbi9VFTZip7h2QLtaI9b2lg6shXe45qDK9MjM5_TyWzaOdZjcj4enR2dhL7lQqgBSixDQCcRN1xHtTAcFqqKcZnLLFFVWgncMFUKwtREAJNKRBJS1dgYV-kyVxKCP31CBhbUu0soY4YDQDBS64ppmUoVS5ML5Bszkld1QMK15otFx6xRuOO1DFYknQoLtFThLRWQj2iejSzyYrsfmutp4cOsAHgjda2jRKWa6UwobkoNH5HyKomrKArISzRu0V0y3UR3MWQxJK4MwF5AXjsJ5MawWHwzVau2LT59_fEfQt-_9YTeeqG6ATfRyl94gP-Epu1J7vckIcJ1b3gXXXGtlba4iQV4cu2etw-_2gzjS7Ggzppm5WQYyxiTLCBPO2_eaBZW5BGHTB-QrOfnPdX3R-zsp6MmZzAhgEM8-_dn7ZEHgDuZq7gT-2SwvF6Z54DtluULF8C_AeecTV0
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLZGeeEFMW4LDDAICXjIlCa2Ez8gVKaOgVSYYEV7ixzH6Sp1Tmlaafx7znHciKAi7TXnOErOxf58-w4hr4UcZjCw6bBimQpZUWRhISoTFlyxQsXalI5SaPJVnE7Zlwt-sUe2NVu9AZudUzusJzVdLY6uf_3-AAn_3lVtSIfbRkfL2pojJMgUIr1FbscwNuIhrwnr9hUgu93uJaKWUMRR4i_T_e8tvcHKcfp3PfdguaibXbD039OVfw1XJ_fIXY8z6agNjH2yZ-x9su8zuaFvPd30uwfEjugn06z9oiA9a4t407qiZ7jEjrcl6fi6buoraDe3dKJa3mgUN1eKKlvSc9xuoC0TckNrS8e2xKtdC4huemwWCzqZz9pYe0imJ-Pz49PQV2EINaCLdQiAJeKG66gShsPcVTEuM5nGqkxKgWuoSkHmmgiQU4HgQqoKa-UqXWRKQn-QPCIDCzY9IJQxwwEzGKl1ybRMpBpKkwmkIDOSl1VAwq2582VLtpG7HbcUJimt3XJ0T-7dE5CP6JNOF6my3YN6Nct95uWAeKSudBSrRDOdCsVNoeEjEl7GwzKKAvICPZq39067hM9HbAh9WQr4LyCvnAbSZVg8jzNTm6bJP3_7eQOlH997Sm-8UlVDbGjl70DAP6Fre5qHPU1Iet0TH2D8ba3S5AjbU8bTOIOW25jcLX7ZifGleMbOmnrjdBhLGZMsII_bEO4sC5P0iEPnH5C0F9w90_cldn7p2MoZjBEQEE9uYsSn5A4AUuaO4olDMlivNuYZgL518dzl8R-0z1Pb
  priority: 102
  providerName: Scholars Portal
Title A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration
URI https://www.ncbi.nlm.nih.gov/pubmed/24905832
https://www.proquest.com/docview/1533745728
https://search.proquest.com/docview/1534474494
https://pubmed.ncbi.nlm.nih.gov/PMC4048215
https://doaj.org/article/1909cfc02a3c4c76a5ebc22e35d21d00
http://dx.doi.org/10.1371/journal.pone.0098667
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2cuGCGF8LjGIQEnBImw_biY9d1W4gdVRjQ71FjuN0lVqnWlqJP59nx6kI2gFx8aF-rpL3Yf_svPczQh8ZD1NY2KRfklT4JM9TP2el8nMqSC4iqQpLKTS7Ype35NuCLo4QbWthbNK-zFcDvd4M9OrO5lZuN3LY5okN57MxAbeDpWp4jI5h-W236M30CwHMmKuRi5Nw6Ewy2FZaDQx7JmPm4j3YdQQ0jaPOcmRZ-w9zc2-7ruqHgOff-ZN_LEjTp-iJQ5J41DzxCTpS-hk6cbFa48-OUPrLc6RH-ELVO3fsh-fNNd24KvHcHKKbekg8-VXV1QbGrTSeiYYZ2nTXG4GFLvCN-aCAG67jGlcaT3RhirfW4L94rNZrPFstG296gW6nk5vxpe_uWfAl4IedD5AkoIrKoGSKwu5UEMpTnkSiiAtmTkmFgNhUAWCj3MAHLkpzG66QeSo4RHz8EvU0qPcUYUIUBVSguJQFkTzmIuQqZYZkTHFalB7yW3Vn24ZOI7Pf1BLYhjR6y4ylMmcpD50bmxxkDRm2_aG6X2bOJTLANFyWMohELIlMmKAql_AQMS2isAgCD70zFs2aytJDSGcjEsJslQDC89AHK2EIMbTJuFmKfV1nX7___AehH9cdoU9OqKzAN6RwVQ7wTsa0HcmzjiSEtex0nxr_a7VSZwaYJ4QmUQojW598uPv9odv8qcmi06raWxlCEkI48dCrxoUPmm0DwkNJx7k7qu_2QHhaPnIXjq__e-Qb9BhwKLEZeOwM9Xb3e_UWsN4u70OELxJo03Fo2ulFHz06n1zNr_v29ATaGUn7dgb4DaqfWQs
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,12223,12765,21388,24318,27924,27925,31719,31720,33266,33267,33373,33374,33744,33745,43310,43579,43600,43805,53791,53793,73745,74014,74035,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegk4AXxMbHAoMZhAQ8ZEsaO4mfUDd1dLCWanRob5bjOKVS55SllfjzuUvcjqAJ8VpfovS-_PPZ_h0hb2MRpjCxab9gqfJZlqV-FhfGz7himepqk9eUQsNRPLhgny_5pSu4Ve5Y5Ton1ok6LzXWyA8RlySMJ9304-Knj12jcHfVtdC4S7aQOZ13yNZRfzQ-X-diiOY4dhfmoiQ8dPY5WJTWHCCVZlz3l7-ZkGre_k127izmZXUb9Pz7BOUfU9LJI_LQYUnaa4y_Te4Yu0PuDd1u-Q7ZdoFb0feOXfrDY2J79JOplq4GSMdNz25aFnSMFXW8HEn7v8qqvILnZpYOVUMTjcPVlaLK5nSCuwu0IT6uaGlp3-Z4k2sOzkyPzXxOh7Np41pPyMVJf3I88F3TBV8DmFj6gE8CbrgOithwWKoqxkUqkq7KozzGkqlSEKgmAKCUIZYQqsDWuEpnqRIQ_tFT0rGg3l1CGTMcIIIRWudMi0ioUJg0RsYxI3heeMRfa14uGm4NWW-wJbAmaVQo0VLSWcojR2iejSwyY9c_lNdT6QJNAsARutBBV0Wa6SRW3GQaPiLieTfMg8Aj-2hc2Vwz3cS37LEQUlcCcM8jb2oJZMewePxmqlZVJU-_fv8PoW_nLaF3TqgowU20clce4D-haVuSey1JiHHdGt5FV1xrpZI30QBPrt3z9uHXm2F8KR6ps6Zc1TKMJYwJ5pFnjTdvNAtr8oBDrvdI0vLzlurbI3b2oyYnZzAlgEM8__dn7ZP7g8nwTJ6djr68IA8AhbL6_F28RzrL65V5CUhvmb1y4fwbQdFRrg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegkyZeEBsfCwxmEBLwkDVN7CR-Qt1o2YCWamxob5bjOKVS55SllfjzuUvcjqAJ8VpfovS-_LN9_h0hr2PRS2Fi037BUuWzLEv9LC6Mn3HFMhVqk9eUQqNxfHLBPl3yS1f_VLmyynVOrBN1XmrcI-8iLkkYT8K0W7iyiMmH4fvFTx87SOFJq2uncZdswawYhB2ydTQYT87WeRkiO47d5bko6XWdrQ4XpTWHSKsZ173mbyanmsN_k6k7i3lZ3QZD_66m_GN6Gj4g9x2upP3GEXbIHWN3yfbInZzvkh0XxBV965im3z0ktk8_mmrp9gPppOnfTcuCTnB3HS9K0sGvsiqv4LmZpSPVUEbjcHWlqLI5PceTBtqQIFe0tHRgc7zVNQfHpsdmPqej2bRxs0fkYjg4Pz7xXQMGX4MKlz5glYAbroMiNhyWrYpxkYokVHmUx7h9qhQErQkANGWIK4QqsE2u0lmqBKSC6DHpWFDvHqGMGQ5wwQitc6ZFJFRPmDRG9jEjeF54xF9rXi4ang1ZH7YlsD5pVCjRUtJZyiNHaJ6NLLJk1z-U11Ppgk4C2BG60EGoIs10EituMg0fEfE87OVB4JEDNK5srpxuYl32WQ_SWALQzyOvaglkyrDoc1O1qip5-vX7fwh9O2sJvXFCRQluopW7_gD_CU3bktxvSUK869bwHrriWiuVvIkMeHLtnrcPv9wM40uxvM6aclXLMJYwJphHnjTevNEsrM8DDnnfI0nLz1uqb4_Y2Y-aqJzB9AAO8fTfn3VAtiGS5ZfT8edn5B4AUlaX4sX7pLO8XpnnAPqW2QsXzb8BPHdV2w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Gestational+Profile+of+Placental+Exosomes+in+Maternal+Plasma+and+Their+Effects+on+Endothelial+Cell+Migration&rft.jtitle=PloS+one&rft.au=Salomon%2C+Carlos&rft.au=Torres%2C+Maria+Jose&rft.au=Kobayashi%2C+Miharu&rft.au=Scholz-Romero%2C+Katherin&rft.date=2014-06-06&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=9&rft.issue=6&rft_id=info:doi/10.1371%2Fjournal.pone.0098667&rft.externalDBID=IOV&rft.externalDocID=A418707251
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon