PDGFRA Amplification is Common in Pediatric and Adult High‐Grade Astrocytomas and Identifies a Poor Prognostic Group in IDH 1 Mutant Glioblastoma

• Published in: Brain pathology (Zurich, Switzerland) Vol. 23; no. 5; pp. 565 - 573
• Main Authors: Phillips, Joanna J., Aranda, Derick, Ellison, David W., Judkins, Alexander R., Croul, Sidney E., Brat, Daniel J., Ligon, Keith L., Horbinski, Craig, Venneti, Sriram, Zadeh, Gelareh, Santi, Mariarita, Zhou, Shengmei, Appin, Christina L., Sioletic, Stefano, Sullivan, Lisa M., Martinez‐Lage, Maria, Robinson, Aaron E., Yong, William H., Cloughesy, Timothy, Lai, Albert, Phillips, Heidi S., Marshall, Roxanne, Mueller, Sabine, Haas‐Kogan, Daphne A., Molinaro, Annette M., Perry, Arie
• Format: Journal Article
• Language: English
• Published: 01.09.2013

Abstract High‐grade astrocytomas ( HGAs ), corresponding to W orld H ealth O rganization grades III (anaplastic astrocytoma) and IV (glioblastoma; GBM ), are biologically aggressive, and their molecular classification is increasingly relevant to clinical management. PDGFRA amplification is common in...