Recapitulation of hepatitis B virus–host interactions in liver organoids from human induced pluripotent stem cells

• Published in: EBioMedicine Vol. 35; pp. 114 - 123
• Main Authors: Nie, Yun-Zhong, Zheng, Yun-Wen, Miyakawa, Kei, Murata, Soichiro, Zhang, Ran-Ran, Sekine, Keisuke, Ueno, Yasuharu, Takebe, Takanori, Wakita, Takaji, Ryo, Akihide, Taniguchi, Hideki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2018; Elsevier
• Subjects: Advanced Basic Science; Cell Line; Hepatitis B - pathology; Hepatitis B - virology; Hepatitis B virus; Hepatitis B virus - physiology; hiPSC; Host-Pathogen Interactions; Humans; Induced Pluripotent Stem Cells - ultrastructure; Induced Pluripotent Stem Cells - virology; Internal Medicine; Liver - pathology; Liver - physiopathology; Liver - virology; Liver organoid; Organoids - ultrastructure; Organoids - virology; Research paper; Virus-host interactions; Liver organoid; Hepatitis B virus; hiPSC; Virus-host interactions

Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid...