The promise of induced pluripotent stem cells in research and therapy

• Published in: Nature (London) Vol. 481; no. 7381; pp. 295 - 305
• Main Authors: Robinton, Daisy A., Daley, George Q.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2012; Nature Publishing Group
• Subjects: 631/136/2444; 631/532/2064/2158; 631/532/2435; 692/700/565/2319; Animals; Biological and medical sciences; Biological Assay; Cellular Reprogramming; Disease; DNA binding proteins; DNA methylation; Embryonic stem cells; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Epigenesis, Genetic; General aspects; Genetic disorders; Genetic engineering; Genomes; Humanities and Social Sciences; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Medical sciences; multidisciplinary; Physiological aspects; Regenerative Medicine - trends; review-article; Science; Science (multidisciplinary); Stem Cell Research; Stem cells; Studies; Transplantation; Transplants & implants; United States; Human; Treatment; Disease; Regenerative medicine; Induced pluripotent stem cell; Review; Fundamental research
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/nature10761

The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modelling human diseases and...