Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1

• Published in: PloS one Vol. 10; no. 1; p. e0116543
• Main Authors: Musto, Alberto E, Walker, Chelsey P, Petasis, Nicos A, Bazan, Nicolas G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.01.2015; Public Library of Science (PLoS)
• Subjects: Aberration; Animals; Biological activity; Cellular communication; Dendritic spines; Dendritic Spines - drug effects; Dendritic Spines - pathology; Docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Drug dosages; Epilepsy; Epilepsy, Temporal Lobe - pathology; Epilepsy, Temporal Lobe - physiopathology; Fatty acids; Health sciences; Hippocampus; House mouse; Limbic System - drug effects; Limbic System - pathology; Male; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; Microelectrodes; Nerve Net - drug effects; Neural networks; Neuroprotection; Neurosciences; Omega 3 fatty acids; Pilocarpine; Rodents; Seizures; Seizures (Medicine); Signaling; Silicon; Status Epilepticus - chemically induced; Status Epilepticus - drug therapy; Status Epilepticus - pathology; Stratum radiatum; Temporal lobe; Unsaturated fatty acids

Limbic epileptogenesis triggers molecular and cellular events that foster the establishment of aberrant neuronal networks that, in turn, contribute to temporal lobe epilepsy (TLE). Here we have examined hippocampal neuronal network activities in the pilocarpine post-status epilepticus model of limbi...