EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma

• Published in: Neurologia medico-chirurgica Vol. 59; no. 3; pp. 89 - 97
• Main Authors: NOZAWA, Takanori, OKADA, Masayasu, NATSUMEDA, Manabu, EDA, Takeyoshi, ABE, Hideaki, TSUKAMOTO, Yoshihiro, OKAMOTO, Kouichirou, OISHI, Makoto, TAKAHASHI, Hitoshi, FUJII, Yukihiko, KAKITA, Akiyoshi
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 01.01.2019; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: Aged; Aged, 80 and over; Brain Neoplasms - metabolism; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Cell proliferation; Cell surface; Cohort Studies; distribution; EGFRvIII; Epidermal growth factor; ErbB Receptors - metabolism; Female; Glial cells; Glial fibrillary acidic protein; Glioblastoma; Glioblastoma - metabolism; Glioblastoma - mortality; Glioblastoma - pathology; Glioma cells; Humans; Immunofluorescence; Immunohistochemistry; Isocitrate dehydrogenase; Localization; Male; Middle Aged; morphology; Original; Physical characteristics; prognosis; Survival Rate; Therapeutic applications; Tumor cells; EGFRvIII; glioblastoma; morphology; distribution; prognosis

Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific cell surface antigen often expressed in glioblastoma and has drawn much attention as a possible therapeutic target. We performed immunohistochemistry on histology sections of surgical specimens taken from 67 cases with gliob...