Intracranial Aneurysm as a Macrophage-mediated Inflammatory Disease

• Published in: Neurologia medico-chirurgica Vol. 59; no. 4; pp. 126 - 132
• Main Authors: SHIMIZU, Kampei, KUSHAMAE, Mika, MIZUTANI, Tohru, AOKI, Tomohiro
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 2019; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: Aneurysm; Aneurysms; Animal models; chronic inflammation; Drug therapy; EP2; Gene deletion; Inflammatory diseases; intracranial aneurysm; macrophage; Macrophages; Monocyte chemoattractant protein 1; Monocytes; NF-kB; Nuclear transport; Pathogenesis; Prostaglandin E; Rupture; Special Topic; Subarachnoid hemorrhage; macrophage; intracranial aneurysm; EP2; chronic inflammation; NF-kB

Subarachnoid hemorrhage (SAH) is mainly attributable to the rupture of intracranial aneurysms (IAs). Although the outcome of SAH is considerably poor in spite of the recent intensive medical care, mechanisms regulating the progression of IAs or triggering rupture remain to be clarified, making the d...