Copy number increase of oncoprotein CIP 2A is associated with poor patient survival in human head and neck squamous cell carcinoma

• Published in: Journal of oral pathology & medicine Vol. 45; no. 5; pp. 329 - 337
• Main Authors: Routila, Johannes, Bilgen, Türker, Saramäki, Outi, Grénman, Reidar, Visakorpi, Tapio, Westermarck, Jukka, Ventelä, Sami
• Format: Journal Article
• Language: English
• Published: 01.05.2016

Background CIP 2A, an inhibitor of PP 2A tumour suppressor function, is a widely overexpressed biomarker of aggressive disease and poor therapy response in multiple human cancer types. Methods CIP 2A and DPPA 4 copy number alterations and expression were analysed by fluorescence in situ hybridisatio...