Nonlinear interaction between APOE ε 4 allele load and age in the hippocampal surface of cognitively intact individuals

• Published in: Human brain mapping Vol. 42; no. 1; pp. 47 - 64
• Main Authors: Martí‐Juan, Gerard, Sanroma‐Guell, Gerard, Cacciaglia, Raffaele, Falcon, Carles, Operto, Grégory, Molinuevo, José Luis, González Ballester, Miguel Ángel, Gispert, Juan Domingo, Piella, Gemma
• Format: Journal Article
• Language: English
• Published: 01.01.2021

Abstract The ε 4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε 4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including atrophy of the hippocampus, which is one of the brain structures...