Novel Antagonists Acting at the P2Y 1 Purinergic Receptor: Synthesis and Conformational Analysis Using Potentiometric and Nuclear Magnetic Resonance Titration Techniques
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Published in | Journal of medicinal chemistry Vol. 45; no. 4; pp. 962 - 972 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.02.2002
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Online Access | Get full text |
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Author | Gachet, Christian Retat, Myriam Baurand, Anthony Spiess, Bernard Bourguignon, Jean-Jacques Cazenave, Jean-Pierre Raboisson, Pierre |
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Author_xml | – sequence: 1 givenname: Pierre surname: Raboisson fullname: Raboisson, Pierre organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 2 givenname: Anthony surname: Baurand fullname: Baurand, Anthony organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 3 givenname: Jean-Pierre surname: Cazenave fullname: Cazenave, Jean-Pierre organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 4 givenname: Christian surname: Gachet fullname: Gachet, Christian organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 5 givenname: Myriam surname: Retat fullname: Retat, Myriam organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 6 givenname: Bernard surname: Spiess fullname: Spiess, Bernard organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France – sequence: 7 givenname: Jean-Jacques surname: Bourguignon fullname: Bourguignon, Jean-Jacques organization: Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR 7081 du CNRS, Faculté de Pharmacie, Université Louis Pasteur, 74, Route du Rhin, 67401 Illkirch Cedex, France, and Laboratoire de Biologie et de Pharmacologie de l'Hémostase et de la Thrombose, Etablissement Français du Sang-Alsace, U.311 de l'INSERM, 10, Rue Spielmann, BP 36, 67065 Strasbourg Cedex, France |
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Cites_doi | 10.1021/jm00076a023 10.1038/sj.bjp.0701837 10.1139/v76-487 10.1021/jm990156d 10.1006/abio.1995.9984 10.1021/ja00245a059 10.1021/ja00788a038 10.1016/S0008-6215(98)00060-3 10.1021/ar00110a001 10.1021/ja00369a030 10.1021/ac00111a012 10.1021/jo9714425 10.1016/S0014-2999(01)00733-6 10.1021/jm990249v 10.1021/jm970433l 10.1021/ja01006a035 10.1016/S0006-291X(72)80181-5 10.1021/jo00972a008 10.1021/ja00099a061 10.1021/ja992940t 10.1021/ac50002a019 10.1038/35051599 10.1111/j.1432-1033.1987.tb10807.x 10.1161/01.CIR.103.5.718 10.1182/blood.V92.1.152.413k27_152_159 10.1042/bj2780759 10.1021/ja00094a009 10.1021/bi990114r 10.1002/1098-2299(200004)49:4<253::AID-DDR4>3.0.CO;2-1 10.1006/bbrc.1999.1832 |
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