Functional roles for noise in genetic circuits

• Published in: Nature (London) Vol. 467; no. 7312; pp. 167 - 173
• Main Authors: Eldar, Avigdor, Elowitz, Michael B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.09.2010; Nature Publishing Group
• Subjects: 631/136/532; 631/181; 631/553/2707; 631/57/2272; Animals; Architecture; Behavior; Biological and medical sciences; Biological evolution; Cell Physiological Phenomena; Cellular; Circuits; Drug resistance; Electromagnetic noise; Evolution; Evolutionary; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Gene Regulatory Networks; Genetic aspects; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Humanities and Social Sciences; Humans; Microorganisms; Models, Genetic; multidisciplinary; Noise; Nuisance; Physiological aspects; Propagation; Proteins; review-article; Science; Science (multidisciplinary); Signal transduction; Studies; United States; Noise; Biological evolution; Genetic circuit; Physiology; Review; Differentiation; Gene expression

Noise in gene circuits Even genetically identical cells in a homogeneous environment can behave quite differently from one another because of the prevalence of unavoidable random fluctuations, or 'noise', in their levels and activities. Noise is something of a nuisance when it comes to dev...