Functional roles for noise in genetic circuits

Noise in gene circuits Even genetically identical cells in a homogeneous environment can behave quite differently from one another because of the prevalence of unavoidable random fluctuations, or 'noise', in their levels and activities. Noise is something of a nuisance when it comes to dev...

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Published in	Nature (London) Vol. 467; no. 7312; pp. 167 - 173
Main Authors	Eldar, Avigdor, Elowitz, Michael B.
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 09.09.2010 Nature Publishing Group
Subjects	631/136/532 631/181 631/553/2707 631/57/2272 Animals Architecture Behavior Biological and medical sciences Biological evolution Cell Physiological Phenomena Cellular Circuits Drug resistance Electromagnetic noise Evolution Evolutionary Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Regulatory Networks Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences Humans Microorganisms Models, Genetic multidisciplinary Noise Nuisance Physiological aspects Propagation Proteins review-article Science Science (multidisciplinary) Signal transduction Studies United States Noise Biological evolution Genetic circuit Physiology Review Differentiation Gene expression
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Abstract	Noise in gene circuits Even genetically identical cells in a homogeneous environment can behave quite differently from one another because of the prevalence of unavoidable random fluctuations, or 'noise', in their levels and activities. Noise is something of a nuisance when it comes to developing reliable genetic circuits, and various control circuits have evolved to cope with it. But a new wave of studies is showing that noise can, and does, provide vital functions that would be difficult or impossible to achieve in 'noiseless' gene circuits. In this Review, Avigdor Eldar and Michael Elowitz discuss the emerging principles that connect noise, the architecture of gene circuits in which it appears, and the biological functions that it enables. The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or ‘noise’, in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward.
AbstractList	The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward. The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward.The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward. The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward. [PUBLICATION ABSTRACT] Noise in gene circuits Even genetically identical cells in a homogeneous environment can behave quite differently from one another because of the prevalence of unavoidable random fluctuations, or 'noise', in their levels and activities. Noise is something of a nuisance when it comes to developing reliable genetic circuits, and various control circuits have evolved to cope with it. But a new wave of studies is showing that noise can, and does, provide vital functions that would be difficult or impossible to achieve in 'noiseless' gene circuits. In this Review, Avigdor Eldar and Michael Elowitz discuss the emerging principles that connect noise, the architecture of gene circuits in which it appears, and the biological functions that it enables. The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or ‘noise’, in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward.
Audience	Academic
Author	Eldar, Avigdor Elowitz, Michael B.
AuthorAffiliation	1 Howard Hughes Medical Institute, Caltech M/C 114-96, 1200 East California Boulevard, Pasadena, California 91125, USA
AuthorAffiliation_xml	– name: 1 Howard Hughes Medical Institute, Caltech M/C 114-96, 1200 East California Boulevard, Pasadena, California 91125, USA
Author_xml	– sequence: 1 givenname: Avigdor surname: Eldar fullname: Eldar, Avigdor organization: Howard Hughes Medical Institute, Caltech M/C 114-96, 1200 East California Boulevard, Pasadena, California 91125, USA , Present address: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel – sequence: 2 givenname: Michael B. surname: Elowitz fullname: Elowitz, Michael B. email: melowitz@caltech.edu organization: Howard Hughes Medical Institute, Caltech M/C 114-96, 1200 East California Boulevard, Pasadena, California 91125, USA
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23182546$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20829787$$D View this record in MEDLINE/PubMed
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Copyright	Springer Nature Limited 2010 2015 INIST-CNRS COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Sep 9, 2010 2010 Macmillan Publishers Limited. All rights reserved 2010
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3 Present address: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
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Snippet	Noise in gene circuits Even genetically identical cells in a homogeneous environment can behave quite differently from one another because of the prevalence of... The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from... The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or `noise', in the levels of their components. Noise, far from...
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SubjectTerms	631/136/532 631/181 631/553/2707 631/57/2272 Animals Architecture Behavior Biological and medical sciences Biological evolution Cell Physiological Phenomena Cellular Circuits Drug resistance Electromagnetic noise Evolution Evolutionary Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Regulatory Networks Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences Humans Microorganisms Models, Genetic multidisciplinary Noise Nuisance Physiological aspects Propagation Proteins review-article Science Science (multidisciplinary) Signal transduction Studies
Title	Functional roles for noise in genetic circuits
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