Regulation of histone H3K4 methylation in brain development and disease

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 369; no. 1652; p. 20130514
• Main Authors: Shen, Erica, Shulha, Hennady, Weng, Zhiping, Akbarian, Schahram
• Format: Journal Article
• Language: English
• Published: England The Royal Society 26.09.2014
• Subjects: Animals; Autism; Autistic Disorder - genetics; Autistic Disorder - metabolism; Brain - growth & development; Brain - physiopathology; Chromatin; Epigenesis, Genetic - physiology; Epigenetic; Histone; Histone Demethylases - metabolism; Histone-Lysine N-Methyltransferase - metabolism; Histones - metabolism; Humans; Methylation; Mice; Mutation - genetics; Nervous System Diseases - genetics; Nervous System Diseases - metabolism; Nervous System Diseases - physiopathology; Nucleosome; Part IV: Intercellular communication—clinical insight; Review; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; nucleosome; histone; schizophrenia; chromatin; epigenetic; autism

The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wid...