Disruption of alpha-tubulin releases carbon catabolite repression and enhances enzyme production in Trichoderma reesei even in the presence of glucose

• Published in: Biotechnology for Biofuels Vol. 14; no. 1; p. 39
• Main Authors: Shibata, Nozomu, Kakeshita, Hiroshi, Igarashi, Kazuaki, Takimura, Yasushi, Shida, Yosuke, Ogasawara, Wataru, Koda, Tohru, Hasunuma, Tomohisa, Kondo, Akihiko
• Format: Journal Article
• Language: English
• Published: England Springer Science and Business Media LLC 08.02.2021; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Ascomycota; biofuels; Biomass; Biomass saccharification enzyme; Biotechnology; Carbon; Carbon catabolite repression; Catabolite repression; Cellobiose; Cellulase; Cellulose; Dextrose; Disruption; endo-1,4-beta-glucanase; Enzymes; Fermenters; Fuel; Fungi; Gene expression; Genes; Genomes; Glucose; Glucose resistant; Hemicellulase; Hemicellulases; Morphology; Physiological aspects; protein synthesis; Proteins; Reduction; secretion; TP248.13-248.65; TP315-360; Transcription; transcription factors; Transcriptomes; transcriptomics; Trichoderma reesei; Tubulin; Tubulins; Japan; Cellulase; Glucose resistant; Biomass saccharification enzyme; Carbon catabolite repression; Alpha-tubulin; Hemicellulase; Trichoderma reesei

Trichoderma reesei is a filamentous fungus that is important as an industrial producer of cellulases and hemicellulases due to its high secretion of these enzymes and outstanding performance in industrial fermenters. However, the reduction of enzyme production caused by carbon catabolite repression...