Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study

• Published in: PLoS medicine Vol. 18; no. 7; p. e1003707
• Main Authors: Liu, Chi-Hung, Sung, Pi-Shan, Li, Yan-Rong, Huang, Wen-Kuan, Lee, Tay-Wey, Huang, Chin-Chang, Lee, Tsong-Hai, Chen, Tien-Hsing, Wei, Yi-Chia
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 19.07.2021; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Angiotensin; Antihypertensives; Atherosclerosis; Cardiovascular disease; Chronic illnesses; Codes; Cognitive ability; Cohort analysis; Comorbidity; Dementia; Dementia disorders; Diabetes; Diabetes mellitus (non-insulin dependent); Diagnosis; Diuretics; Drug therapy; Drugs; Hypertension; Insulin resistance; Ischemia; Mathematical models; Medicine and Health Sciences; Mortality; Neurodegenerative diseases; Patient outcomes; Patients; Peroxisome proliferator-activated receptors; Pharmacy; Population studies; Population-based studies; Psychiatrists; Risk factors; Stroke; Telmisartan; Traumatic brain injury; Type 2 diabetes; Taiwan

Angiotensin receptor blockers (ARBs) may have protective effects against dementia occurrence in patients with hypertension (HTN). However, whether telmisartan, an ARB with peroxisome proliferator-activated receptor [gamma] (PPAR-[gamma])-modulating effects, has additional benefits compared to other...