The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease
Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structu...
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| Published in | Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 369; no. 1652; p. 20130507 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Royal Society
26.09.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0962-8436 1471-2970 1471-2970 |
| DOI | 10.1098/rstb.2013.0507 |
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| Abstract | Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structures, regulated expression and evolutionary conservation. Some lncRNAs have been shown to associate with chromatin-modifying activities and transcription factors, suggesting that a common mode of action may be to guide protein complexes to target genomic loci. However, the functions (if any) of the vast majority of lncRNA transcripts are currently unknown, and the subject of investigation. Here, we consider the putative role(s) of lncRNAs in neurodevelopment and brain function with an emphasis on the epigenetic regulation of gene expression. Associations of lncRNAs with neurodevelopmental/neuropsychiatric disorders, neurodegeneration and brain cancers are also discussed. |
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| AbstractList | Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structures, regulated expression and evolutionary conservation. Some lncRNAs have been shown to associate with chromatin-modifying activities and transcription factors, suggesting that a common mode of action may be to guide protein complexes to target genomic loci. However, the functions (if any) of the vast majority of lncRNA transcripts are currently unknown, and the subject of investigation. Here, we consider the putative role(s) of lncRNAs in neurodevelopment and brain function with an emphasis on the epigenetic regulation of gene expression. Associations of lncRNAs with neurodevelopmental/neuropsychiatric disorders, neurodegeneration and brain cancers are also discussed. Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structures, regulated expression and evolutionary conservation. Some lncRNAs have been shown to associate with chromatin-modifying activities and transcription factors, suggesting that a common mode of action may be to guide protein complexes to target genomic loci. However, the functions (if any) of the vast majority of lncRNA transcripts are currently unknown, and the subject of investigation. Here, we consider the putative role(s) of lncRNAs in neurodevelopment and brain function with an emphasis on the epigenetic regulation of gene expression. Associations of lncRNAs with neurodevelopmental/neuropsychiatric disorders, neurodegeneration and brain cancers are also discussed.Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structures, regulated expression and evolutionary conservation. Some lncRNAs have been shown to associate with chromatin-modifying activities and transcription factors, suggesting that a common mode of action may be to guide protein complexes to target genomic loci. However, the functions (if any) of the vast majority of lncRNA transcripts are currently unknown, and the subject of investigation. Here, we consider the putative role(s) of lncRNAs in neurodevelopment and brain function with an emphasis on the epigenetic regulation of gene expression. Associations of lncRNAs with neurodevelopmental/neuropsychiatric disorders, neurodegeneration and brain cancers are also discussed. |
| Author | Wood, Matthew J. A. Roberts, Thomas C. Morris, Kevin V. |
| AuthorAffiliation | 3 School of Biotechnology and Biomedical Sciences , University of New South Wales , Sydney, New South Wales 2052 , Australia 1 Department of Physiology, Anatomy and Genetics , University of Oxford , South Parks Road, Oxford OX1 3QX , UK 2 Department of Molecular and Experimental Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, CA 92037 , USA |
| AuthorAffiliation_xml | – name: 1 Department of Physiology, Anatomy and Genetics , University of Oxford , South Parks Road, Oxford OX1 3QX , UK – name: 2 Department of Molecular and Experimental Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, CA 92037 , USA – name: 3 School of Biotechnology and Biomedical Sciences , University of New South Wales , Sydney, New South Wales 2052 , Australia |
| Author_xml | – sequence: 1 givenname: Thomas C. surname: Roberts fullname: Roberts, Thomas C. organization: Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK – sequence: 2 givenname: Kevin V. surname: Morris fullname: Morris, Kevin V. organization: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 3 givenname: Matthew J. A. surname: Wood fullname: Wood, Matthew J. A. email: matthew.wood@dpag.ox.ac.uk organization: Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25135968$$D View this record in MEDLINE/PubMed |
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| Snippet | Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell.... |
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| Title | The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease |
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