Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 2; pp. 306 - 313
• Main Authors: Daham, Kameran, James, Anna, Balgoma, David, Kupczyk, Maciej, Billing, Bo, Lindeberg, Agneta, Henriksson, Elisabeth, FitzGerald, Garret A., Wheelock, Craig E., Dahlén, Sven-Erik, Dahlén, Barbro
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.08.2014; Elsevier Limited
• Subjects: Adult; airway hyperresponsiveness; Airway management; Allergens - administration & dosage; Allergy and Immunology; Asthma; Asthma - drug therapy; Asthma - enzymology; Asthma - immunology; Asthma - pathology; Biosynthesis; Bronchial Provocation Tests; Bronchoconstriction - drug effects; Bronchoconstriction - immunology; COX; Cross-Over Studies; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - therapeutic use; Drug dosages; Drug therapy; eicosanoids; Eosinophils - immunology; Eosinophils - pathology; Female; Forced Expiratory Volume; Humans; Inflammation - drug therapy; Inflammation - enzymology; Inflammation - immunology; Inflammation - pathology; leukotrienes; Male; mass spectrometry; Methacholine Chloride - administration & dosage; Middle Aged; Nitric oxide; Nitric Oxide - biosynthesis; Nonsteroidal anti-inflammatory drugs; NSAIDs; prostaglandin; Prostaglandins - urine; Pyridines - therapeutic use; Respiratory diseases; Sputum - cytology; Sulfones - therapeutic use; thromboxane; urinary metabolites; thromboxane; PGD2; airway hyperresponsiveness; Feno; PGE2; prostaglandin; PGI2; PGF1α; COX; leukotrienes; Asthma; urinary metabolites; PGE; eicosanoids; TXA2; TXB2; NSAIDs; mass spectrometry; TXA 2; PGE 2; Fractional exhaled nitric oxide; PGI 2; TXB 2; Nonsteroidal anti-inflammatory drugs; Prostaglandin E; Thromboxane B 2; Thromboxane A 2; F eno; Prostaglandin F 1α; PGD 2; Prostaglandin I 2; Prostaglandin D 2; Prostaglandin E 2; PGF 1α

Prostaglandins that constrict and relax airways are synthesized in reactions catalyzed by either COX-1 or COX-2. It is not known whether selective inhibition of COX-2 makes asthmatic responses better or worse. To determine the effects of the selective COX-2 inhibitor, etoricoxib, on allergen-induced...